Gene-Environment Interaction Search Result

Search by: All gene-environment interaction results.

Total result: 268

Marker Name	Related Gene	Phenotype	Environment	Statistical Results (Interaction)	Author's Comments	Marker's Category	Reference
rs8042149	RORA	PTSD symptom severity	Earthquake exposure	Females: B=0.058, t=0.818, P-value=0.414, Males: B=0.283, t=...... Females: B=0.058, t=0.818, P-value=0.414, Males: B=0.283, t=2.329, P-value=0.020. More...	The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was associated with total PTSD symptoms in males. More...	Significant	Cao, C.,2017
rs8042149	RORA	Intrusion symptom	Earthquake exposure	Females: B=0.114, t=1.591, P-value=0.112, Males: B=0.191, t=...... Females: B=0.114, t=1.591, P-value=0.112, Males: B=0.191, t=1.562, P-value=0.119. More...	The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was not significant. More...	Non-significant	Cao, C.,2017
rs8042149	RORA	Avoidance symptom	Earthquake exposure	Females: B=0.028, t=0.378, P-value=0.705, Males: B=0.173, t=...... Females: B=0.028, t=0.378, P-value=0.705, Males: B=0.173, t=1.402, P-value=0.162. More...	The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was not significant. More...	Non-significant	Cao, C.,2017
rs8042149	RORA	Negative affect symptom	Earthquake exposure	Females: B=0.019, t=0.261, P-value=0.794, Males: B=0.293, t=...... Females: B=0.019, t=0.261, P-value=0.794, Males: B=0.293, t=2.371, P-value=0.018. More...	The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was associated with severity of the negative affect symptoms in males. More...	Significant	Cao, C.,2017
rs8042149	RORA	Anhedonia symptom	Earthquake exposure	Females: B=0.043, t=0.588, P-value=0.557, Males: B=0.262, t=...... Females: B=0.043, t=0.588, P-value=0.557, Males: B=0.262, t=2.132, P-value=0.034. More...	The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was associated with anhedonia symptoms in males. More...	Significant	Cao, C.,2017
rs8042149	RORA	Externalizing behaviors symptom	Earthquake exposure	Females: B=0.046, t=0.612, P-value=0.540, Males: B=0.224, t=...... Females: B=0.046, t=0.612, P-value=0.540, Males: B=0.224, t=1.805, P-value=0.072. More...	The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was not significant. More...	Non-significant	Cao, C.,2017
rs8042149	RORA	Anxious arousal symptom	Earthquake exposure	Females: B=0.053, t=0.710, P-value=0.478, Males: B=0.186, t=...... Females: B=0.053, t=0.710, P-value=0.478, Males: B=0.186, t=1.502, P-value=0.134. More...	The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was not significant. More...	Non-significant	Cao, C.,2017
rs8042149	RORA	Dysphoria arousal symptom	Earthquake exposure	Females: B=-0.049, t=-0.658, P-value=0.511, Males: B=0.325, ...... Females: B=-0.049, t=-0.658, P-value=0.511, Males: B=0.325, t=2.642, P-value=0.009. More...	The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was associated with dysphoric arousal symptoms in males. More...	Significant	Cao, C.,2017
rs6295	HTR1A	PTSD diagnosis	Childhood trauma	P-value>0.05 P-value>0.05	No significant associations were observed. No significant associations were observed.	Non-significant	Donaldson, Z. R.,2016
rs6295	HTR1A	PTSD diagnosis	Non-childhood trauma	P-value>0.05 P-value>0.05	No significant associations were observed. No significant associations were observed.	Non-significant	Donaldson, Z. R.,2016
rs2400707	ADRB2	PTSD diagnosis	Childhood trauma	Among the NHB cohort: P-value=0.038. Among the NHW cohort: P...... Among the NHB cohort: P-value=0.038. Among the NHW cohort: P-value=0.892. More...	The interaction with rs2400707 and childhood trauma was obse...... The interaction with rs2400707 and childhood trauma was observed among NMB participants but not observed among the NHW study participants. More...	Significant	Hauser, M. A.,2017
rs3800373	FKBP5	Lifetime PTSD symptoms	Childhood abuse	Main sample: F=3.47, P-value=0.031. Replication sample: F=5....... Main sample: F=3.47, P-value=0.031. Replication sample: F=5.51, P-value=0.004. More...	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant	Watkins, L. E.,2016
rs9296158	FKBP5	Lifetime PTSD symptoms	Childhood abuse	Main sample: F=2.50, P-value=0.041. Replication sample: F=5....... Main sample: F=2.50, P-value=0.041. Replication sample: F=5.79, P-value=0.003. More...	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant	Watkins, L. E.,2016
rs1360780	FKBP5	Lifetime PTSD symptoms	Childhood abuse	Main sample: F=2.45, P-value=0.044. Replication sample: F=5....... Main sample: F=2.45, P-value=0.044. Replication sample: F=5.79, P-value=0.003. More...	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant	Watkins, L. E.,2016
rs9470080	FKBP5	Lifetime PTSD symptoms	Childhood abuse	Main smaple: F=3.65, P-value=0.006. Replication sample: F=6....... Main smaple: F=3.65, P-value=0.006. Replication sample: F=6.09, P-value=0.002. More...	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant	Watkins, L. E.,2016
rs3800373	FKBP5	Re-experiencing symptoms	Childhood abuse	F=4.03, P-value=0.018 F=4.03, P-value=0.018	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9296158	FKBP5	Re-experiencing symptoms	Childhood abuse	F=3.35, P-value=0.036 F=3.35, P-value=0.036	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs1360780	FKBP5	Re-experiencing symptoms	Childhood abuse	F=1.87, P-value=0.16 F=1.87, P-value=0.16	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9470080	FKBP5	Re-experiencing symptoms	Childhood abuse	F=1.23, P-value=0.29 F=1.23, P-value=0.29	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs3800373	FKBP5	Avoidance symptoms (DSM-IV)	Childhood abuse	F=1.29, P-value=0.27 F=1.29, P-value=0.27	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9296158	FKBP5	Avoidance symptoms (DSM-IV)	Childhood abuse	F=0.57, P-value=0.57 F=0.57, P-value=0.57	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs1360780	FKBP5	Avoidance symptoms (DSM-IV)	Childhood abuse	F=0.77, P-value=0.46 F=0.77, P-value=0.46	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9470080	FKBP5	Avoidance symptoms (DSM-IV)	Childhood abuse	F=0.62, P-value=0.54 F=0.62, P-value=0.54	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs3800373	FKBP5	Emotional numbing	Childhood abuse	F=0.38, P-value=0.68 F=0.38, P-value=0.68	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9296158	FKBP5	Emotional numbing	Childhood abuse	F=0.31, P-value=0.73 F=0.31, P-value=0.73	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs1360780	FKBP5	Emotional numbing	Childhood abuse	F=0.53, P-value=0.59 F=0.53, P-value=0.59	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9470080	FKBP5	Emotional numbing	Childhood abuse	F=0.29, P-value=0.75 F=0.29, P-value=0.75	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs3800373	FKBP5	Hyperarousal symptoms	Childhood abuse	F=4.55, P-value=0.011 F=4.55, P-value=0.011	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9296158	FKBP5	Hyperarousal symptoms	Childhood abuse	F=3.93, P-value=0.020 F=3.93, P-value=0.020	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs1360780	FKBP5	Hyperarousal symptoms	Childhood abuse	F=3.53, P-value=0.030 F=3.53, P-value=0.030	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9470080	FKBP5	Hyperarousal symptoms	Childhood abuse	F=5.14, P-value=0.006 F=5.14, P-value=0.006	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs3800373	FKBP5	Intrusion symptoms	Childhood abuse	F=5.93, P-value=0.003 F=5.93, P-value=0.003	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant	Watkins, L. E.,2016
rs9296158	FKBP5	Intrusion symptoms	Childhood abuse	F=4.40, P-value=0.013 F=4.40, P-value=0.013	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs1360780	FKBP5	Intrusion symptoms	Childhood abuse	F=4.42, P-value=0.013 F=4.42, P-value=0.013	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9470080	FKBP5	Intrusion symptoms	Childhood abuse	F=4.74, P-value=0.009 F=4.74, P-value=0.009	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs3800373	FKBP5	Avoidance symptoms (DSM-5)	Childhood abuse	F=7.71, P-value=0.001 F=7.71, P-value=0.001	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant	Watkins, L. E.,2016
rs9296158	FKBP5	Avoidance symptoms (DSM-5)	Childhood abuse	F=3.84, P-value=0.022 F=3.84, P-value=0.022	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs1360780	FKBP5	Avoidance symptoms (DSM-5)	Childhood abuse	F=4.04, P-value=0.018 F=4.04, P-value=0.018	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9470080	FKBP5	Avoidance symptoms (DSM-5)	Childhood abuse	F=3.00, P-value=0.051 F=3.00, P-value=0.051	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs3800373	FKBP5	Negative alterations in cognitions and mood symptoms	Childhood abuse	F=1.33, P-value=0.26 F=1.33, P-value=0.26	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9296158	FKBP5	Negative alterations in cognitions and mood symptoms	Childhood abuse	F=3.48, P-value=0.032 F=3.48, P-value=0.032	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs1360780	FKBP5	Negative alterations in cognitions and mood symptoms	Childhood abuse	F=3.49, P-value=0.035 F=3.49, P-value=0.035	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9470080	FKBP5	Negative alterations in cognitions and mood symptoms	Childhood abuse	F=4.46, P-value=0.012 F=4.46, P-value=0.012	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs3800373	FKBP5	Alterations in arousal and reactivity symptoms	Childhood abuse	F=5.46, P-value=0.005 F=5.46, P-value=0.005	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant	Watkins, L. E.,2016
rs9296158	FKBP5	Alterations in arousal and reactivity symptoms	Childhood abuse	F=12.88, P-value<0.001 F=12.88, P-value<0.001	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant	Watkins, L. E.,2016
rs1360780	FKBP5	Alterations in arousal and reactivity symptoms	Childhood abuse	F=12.83, P-value<0.001 F=12.83, P-value<0.001	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant	Watkins, L. E.,2016
rs9470080	FKBP5	Alterations in arousal and reactivity symptoms	Childhood abuse	F=14.01, P-value<0.001 F=14.01, P-value<0.001	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant	Watkins, L. E.,2016
rs3091244	CRP	Current PTSD severity	Lifetime trauma exposure	B=2.756, P-value=0.006 B=2.756, P-value=0.006	Rs3091244 moderated the association between lifetime trauma ...... Rs3091244 moderated the association between lifetime trauma exposure and current PTSD severity. More...	Significant	Miller, M. W.,2018
5-HTTLPR	SLC6A4	Anxious arousal symptoms	High exposure	The interaction of 5-HTTPLR S' allele x exposure:B=.44, t=5....... The interaction of 5-HTTPLR S' allele x exposure:B=.44, t=5.47, P-value<.001 More...	Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was significantly associated with anxious arousal symptoms. More...	Significant	Pietrzak, R. H.,2013
5-HTTLPR	SLC6A4	Arousal symptoms	Emotional Abuse	5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=5...... 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=5.80, P-value<0.01; in GTP: F-value=3.18, P-value<0.05. Any S allele interacted with emotional abuse: in DNHS, F(1,129) = 4.80, P-value= .03, and GTP, F(1,538) = 5.70, P-value= .017. More...	A significant interaction was observed between 5-HTTLPR geno...... A significant interaction was observed between 5-HTTLPR genotype and emotional abuse on worst arousal symptom severity after controlling for age and sex among DNHS participants. A significant interaction between 5-HTTLPR genotype and emotional abuse emerged for the arousal symptom clusters among GTP participants. More...	Significant	Walsh, K.,2014
5-HTTLPR multimarker	SLC6A4	Avoidance (2-4 week delta DEQ)	Shooting exposure	White participants only:P-value=0.003. White participants only:P-value=0.003.	Avoidance symptoms were statistically significant. Avoidance symptoms were statistically significant.	Significant	Mercer, K. B.,2012
rs2400707	ADRB2	Avoidance symptoms	Adverse childhood event (ACE)	Subscales of PTSD symptoms, avoidance symptoms: mean B=0.82,...... Subscales of PTSD symptoms, avoidance symptoms: mean B=0.82, SD=0.24, t=3.43, P-value=.0006. More...	All 3 subscales of PTSD symptoms showed rs2400707 x ACE inte...... All 3 subscales of PTSD symptoms showed rs2400707 x ACE interaction, including intrusive and hyperarousal; however, the subscale for avoidance symptoms had the most robust interaction. More...	Significant	Liberzon, I.,2014
5-HTTLPR	SLC6A4	Avoidance symptoms	Emotional Abuse	5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=0...... 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=0.46, P-value.0.1; in GTP: F-value=0.30, P-value>0.1. More...	The interaction between 5-HTTLPR and emotional abuse did not...... The interaction between 5-HTTLPR and emotional abuse did not reach statistical significance for the avoidance symptom severity among DNHS or GTP participants. More...	Non-significant	Walsh, K.,2014
5-HTTLPR	SLC6A4	Avoidance symptoms	High exposure	The interaction of 5-HTTPLR S' allele x exposure:B=.08, t=.5...... The interaction of 5-HTTPLR S' allele x exposure:B=.08, t=.55, P-value<=.59 More...	Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was not significantly associated with avoidance symptoms. More...	Non-significant	Pietrzak, R. H.,2013
rs2267735	ADCYAP1R1	Correlations between chlidhood maltreatment and past month PTS severity	Childhood maltreatment (CM)	CC versus GG group: z-value=2.071, P-value< .05; CC versus C...... CC versus GG group: z-value=2.071, P-value< .05; CC versus CG group: z-value=2.868, P-value< .01. More...	Stratification by ADCYAP1R1 genotype showed that these corre...... Stratification by ADCYAP1R1 genotype showed that these correlations were significant only among genotypes containing the "C" allele. Moreover, correlation coefficients were significantly higher in the CC versus GG group and in the CC versus CG group. More...	Significant	Uddin, M.,2013
5-HTTLPR	SLC6A4	Current Diagnosis of PTSD	Crime rate	Multivariable logistic regression models for crime rate and ...... Multivariable logistic regression models for crime rate and PTSD: in the interaction model, 5-HTTLPR genotype x crime rate: P-value=0.03. Stratified analyses: s' allele of 5-HTTLPR living in low-crime counties), odds ratio (OR)=0.61, 95%CI=0.34, 1.10; in high-crime counties: OR=1.54, 95%CI=0.72, 3.30. More...	Multivariable logistic regression models for crime rate and ...... Multivariable logistic regression models for crime rate and PTSD: In the interaction model, the interaction term for 5-HTTLPR genotype x crime rate was significant. Figure 1 presents the prevalence of PTSD for persons from high-crime-rate counties versus persons from low-crime-rate counties by 5-HTTLPR genotype. Stratified analyses showed that the s' allele of 5-HTTLPR predicted decreased risk of PTSD among persons living in low-crime counties but increased risk in high-crime counties. More...	Significant	Koenen, K. C.,2009
5-HTTLPR	SLC6A4	Current Diagnosis of PTSD	Unemployment rate	Multivariable logistic regression models for unemployment ra...... Multivariable logistic regression models for unemployment rate and PTSD: in the interaction model, 5-HTTLPR genotype x unemployment rate: P-value=0.007. Stratified analyses: s' allele of 5-HTTLPR living in low-unemployment counties:OR=0.35, 95%CI=0.14-0.87; in high-unemployment counties: OR=1.46, 95%CI=0.82-2.61. More...	Multivariable logistic regression models for unemployment ra...... Multivariable logistic regression models for unemployment rate and PTSD: in the interaction model, the interaction term for 5-HTTLPR genotype x unemployment rate was significant. Figure 2 presents the prevalence of PTSD for persons from counties with high unemployment versus those with low unemployment by 5-HTTLPR genotype. Stratified analyses showed that the s' allele of 5-HTTLPR predicted decreased risk of PTSD among persons living in low-unemployment counties but increased risk in high-unemployment counties. Note that because of the loss of power in stratified analyses, only the effect of 5-HTTLPR genotype in low-unemployment counties was statistically significant. More...	Significant	Koenen, K. C.,2009
rs10002308	DDX60L	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.39; in NHW subset: snp and child trauma interaction P-value=0.046. More...	Among the NHW, we observed nominally significant interaction...... Among the NHW, we observed nominally significant interactions with childhood trauma for DDX60L. More...	Non-significant	Ashley-Koch, A. E.,2015
rs10002308	DDX60L	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.88; in NHW subset: snp and total trauma interaction P-value=0.01. More...	The interaction between the total number of traumatic events...... The interaction between the total number of traumatic events and DDX60L in the NHW subset was nominally significant, consistent with the interaction observation with childhood trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs10762479	PRKG1	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.037; in NHW subset: snp and child trauma interaction P-value=0.94. More...	Among the NHB, we observed nominally significant interaction...... Among the NHB, we observed nominally significant interactions with childhood trauma for PRKG1. More...	Non-significant	Ashley-Koch, A. E.,2015
rs10762479	PRKG1	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.61; in NHW subset: snp and total trauma interaction P-value=0.29. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs10768747	Intergenic	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.16. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs10768747	Intergenic	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.50. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs1116255	Intergenic	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and child trauma interaction P-value=0.37. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs1116255	Intergenic	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and total trauma interaction P-value=0.61. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs12232346	LOC101928174	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.94; in NHW subset: snp and child trauma interaction P-value=0.35. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs12232346	LOC101928174	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.62; in NHW subset: snp and total trauma interaction P-value=0.74. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs17504106	Intergenic	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.37. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs17504106	Intergenic	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.02. More...	Among the NHB, we observed nominally significant interaction...... Among the NHB, we observed nominally significant interactions with total trauma for this snp. More...	Non-significant	Ashley-Koch, A. E.,2015
rs2437772	SDC2	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and child trauma interaction P-value=0.56. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs2437772	SDC2	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and total trauma interaction P-value=0.26. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs2862383	Intergenic	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.15. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs2862383	Intergenic	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.50. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs61793204	Intergenic	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and child trauma interaction P-value=0.86. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs61793204	Intergenic	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and total trauma interaction P-value=0.82. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs73419609	UNC13C	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.049. More...	Among the NHB, we observed nominally significant interaction...... Among the NHB, we observed nominally significant interactions with childhood trauma for UNC13C. More...	Non-significant	Ashley-Koch, A. E.,2015
rs73419609	UNC13C	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.74. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs7866350	TBC1D2	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and child trauma interaction P-value=0.51. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs7866350	TBC1D2	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and total trauma interaction P-value=0.15. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs834811	Intergenic	Current PTSD	Childhood trauma	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.83. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
rs834811	Intergenic	Current PTSD	NTE (number of traumatic events)	Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.21. More...	We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More...	Non-significant	Ashley-Koch, A. E.,2015
5-HTTLPR	SLC6A4	Diagnosis of PTSD	High exposure	The interaction of 5-HTTPLR genotype x exposure: Wald=4.55, ...... The interaction of 5-HTTPLR genotype x exposure: Wald=4.55, OR=3.81, 95%CI=1.11-13.03, P-value<0.05. More...	Results of these analyses revealed that after adjustment for...... Results of these analyses revealed that after adjustment for age, sex, and ancestral proportion scores, the interaction of 5-HTTPLR genotype x exposure was significantly associated with probable diagnosis of Ike-related PTSD. More...	Significant	Pietrzak, R. H.,2013
rs893290	RORA	Decreasing versus low posttraumatic stress trajectory	Childhood physical abuse	Interaction between rs893290 and childhood physical abuse: O...... Interaction between rs893290 and childhood physical abuse: OR=1.22, P-value<0.05. More...	The interaction between rs893290 and childhood physical abus...... The interaction between rs893290 and childhood physical abuse was significantly predictive of membership in the decreasing trajectories, relative to the low trajectory. With correction for multiple testing, the interaction remained a significant predictor of decreasing trajectories, relative to the low trajectory. More...	Significant	Lowe, S. R.,2015
APOE_euro4	APOE	Diagnosis of PTSD	Combat exposure	Secondary anlalyses, N=170, interaction between combat expos...... Secondary anlalyses, N=170, interaction between combat exposure and APOE genotype: B=1.534, P-value=0.009 (signif from GEE). Using only White, non-Hispanic participants: P-value=0.001 More...	The interaction of combat exposure and apoE genotype was sig...... The interaction of combat exposure and apoE genotype was significant in secondary anlalyses for dianosis of PTSD. The interaction between combat exposure and apoE genotype remained a significant predictor of the diagnosis of PTSD using only White, non-Hispanic participants. More...	Significant	Lyons, M. J.,2013
5-HTTLPR	SLC6A4	Dysphoric arousal symptoms	High exposure	The interaction of 5-HTTPLR S' allele x exposure:B=.13, t=.9...... The interaction of 5-HTTPLR S' allele x exposure:B=.13, t=.93, P-value<=.36 More...	Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was not significantly associated with dysphoric arousal symptoms. More...	Non-significant	Pietrzak, R. H.,2013
rs893290	RORA	High versus low posttraumatic stress trajectory	Childhood physical abuse	Interaction between rs893290 and childhood physical abuse: O...... Interaction between rs893290 and childhood physical abuse: OR=1.32, P-value<0.05. More...	The interaction between rs893290 and childhood physical abus...... The interaction between rs893290 and childhood physical abuse was significantly predictive of membership in the high trajectories, relative to the low trajectory. With correction for multiple testing, the interaction remained a significant predictor of high trajectories, relative to the low trajectory. More...	Significant	Lowe, S. R.,2015
5-HTTLPR multimarker	SLC6A4	Hyperarousal (2-4 week delta DEQ)	Shooting exposure	White participants only:P-value=0.03. White participants only:P-value=0.03.	Hyperarousal symptoms were statistically significant. Hyperarousal symptoms were statistically significant.	Significant	Mercer, K. B.,2012
rs2400707	ADRB2	Hyperarousal symptoms	Adverse childhood event (ACE)	Subscales of PTSD symptoms, hyperarousal: mean B=0.61, SD=0....... Subscales of PTSD symptoms, hyperarousal: mean B=0.61, SD=0.20, t=3.07, P-value=.002. More...	All 3 subscales of PTSD symptoms showed rs2400707 x ACE inte...... All 3 subscales of PTSD symptoms showed rs2400707 x ACE interaction, including intrusive and hyperarousal; however, the subscale for avoidance symptoms had the most robust interaction. More...	Significant	Liberzon, I.,2014
rs893290	RORA	Increasing versus low posttraumatic stress trajectory	Childhood physical abuse	Interaction between rs893290 and childhood physical abuse: O...... Interaction between rs893290 and childhood physical abuse: OR=1.46, P-value<0.05. More...	The interaction between rs893290 and childhood physical abus...... The interaction between rs893290 and childhood physical abuse was significantly predictive of membership in the increasing trajectories, relative to the low trajectory. More...	Significant	Lowe, S. R.,2015
rs2400707	ADRB2	Intrusive symptoms	Adverse childhood event (ACE)	Subscales of PTSD symptoms, intrusive: mean B=0.47, SD=0.17,...... Subscales of PTSD symptoms, intrusive: mean B=0.47, SD=0.17, t=2.79, P-value=.005. More...	All 3 subscales of PTSD symptoms showed rs2400707 x ACE inte...... All 3 subscales of PTSD symptoms showed rs2400707 x ACE interaction, including intrusive and hyperarousal; however, the subscale for avoidance symptoms had the most robust interaction. More...	Significant	Liberzon, I.,2014
rs2190242	CRHR2	Latent PTSD Severity	Lifetime trauma exposure	Structural equation modeling: unstandardized B= 0.15, P-valu...... Structural equation modeling: unstandardized B= 0.15, P-value= 0.31. More...	Trauma exposure did not interact with the SNP to predict PTS...... Trauma exposure did not interact with the SNP to predict PTSD severity. More...	Non-significant	Wolf, E. J.,2013
rs8192496	CRHR2	Latent PTSD Severity	Lifetime trauma exposure	Structural equation modeling: unstandardized B= 0.22, P-valu...... Structural equation modeling: unstandardized B= 0.22, P-value= 0.09. More...	Trauma exposure did not interact with the SNP to predict PTS...... Trauma exposure did not interact with the SNP to predict PTSD severity. More...	Non-significant	Wolf, E. J.,2013
rs10038727	WWC1	Lifetime PTSD	Lifetime traumatic load	P-value= 0.65 P-value= 0.65	We did not find evidence of a significant interaction betwee...... We did not find evidence of a significant interaction between rs10038727 genotype and lifetime traumatic load in predicting lifetime PTSD status. More...	Non-significant	Sumner, J. A.,2014
rs1360780	FKBP5	Lifetime PTSD	Childhood adversity (Three types of childhood adversity were considered in this study: namely, witnessing or experiencing a violent crime, experiencing sexual abuse, and experiencing physical abuse.)	In African Americans, the effects of childhood adversity x F...... In African Americans, the effects of childhood adversity x FKBP5 genotype on risk for PTSD (before correction for multiple tests): OR=1.58, CI=0.98-2.54, P-value=0.0602. More...	There was no interactive effect of FKBP5 genotypes and child...... There was no interactive effect of FKBP5 genotypes and childhood adversity in EAs or AAs. The results from the secondary analyses are very similar to the primary results. More...	Non-significant	Xie, P.,2010
rs3800373	FKBP5	Lifetime PTSD	Childhood adversity (Three types of childhood adversity were considered in this study: namely, witnessing or experiencing a violent crime, experiencing sexual abuse, and experiencing physical abuse.)	In African Americans, the effects of childhood adversity x F...... In African Americans, the effects of childhood adversity x FKBP5 genotype on risk for PTSD (before correction for multiple tests): OR=1.49, CI=0.93-2.39, P-value=0.0958. More...	There was no interactive effect of FKBP5 genotypes and child...... There was no interactive effect of FKBP5 genotypes and childhood adversity in EAs or AAs. The results from the secondary analyses are very similar to the primary results. More...	Non-significant	Xie, P.,2010
rs9296158	FKBP5	Lifetime PTSD	Childhood adversity (Three types of childhood adversity were considered in this study: namely, witnessing or experiencing a violent crime, experiencing sexual abuse, and experiencing physical abuse.)	In African Americans, the effects of childhood adversity x F...... In African Americans, the effects of childhood adversity x FKBP5 genotype on risk for PTSD (before correction for multiple tests): OR=1.69, CI=1.05-2.71, P-value=0.0282. More...	Before correction for multiple tests, it significantly modif...... Before correction for multiple tests, it significantly modified the effect of childhood adversity on risk for PTSD in AAs (These same two SNPs also were the most significant in the previous study by Binder et al, (2008).) After Bonferroni correction, the signal didn't remain significant. There was no interactive effect of FKBP5 genotypes and childhood adversity in EAs. The results from the secondary analyses are very similar to the primary results. More...	Significant	Xie, P.,2010
rs9470080	FKBP5	Lifetime PTSD	Childhood adversity (Three types of childhood adversity were considered in this study: namely, witnessing or experiencing a violent crime, experiencing sexual abuse, and experiencing physical abuse.)	In African Americans, the effects of childhood adversity x F...... In African Americans, the effects of childhood adversity x FKBP5 genotype on risk for PTSD (before correction for multiple tests): OR=1.96, CI=1.24-3.10, P-value=0.0040. More...	Before correction for multiple tests, two of the four SNPs i...... Before correction for multiple tests, two of the four SNPs in FKBP5 significantly modified the effect of childhood adversity on risk for PTSD in AAs (rs9296158: OR=1.69, 95% CI=1.05-2.71, P=0.03; rs9470080: OR=1.96, 95% CI=1.24-3.10, P=0.004). (These same two SNPs also were the most significant in the previous study by Binder et al, (2008).) After Bonferroni correction, the signal from rs9470080 remained significant. There was no interactive effect of FKBP5 genotypes and childhood adversity in EAs. The results from the secondary analyses are very similar to the primary results. More...	Significant	Xie, P.,2010
5-HTTLPR	SLC6A4	Lifetime PTSD	Childhood adversity (participants were asked whether, by age 13, they had witnessed or experienced a violent crime, had been sexually abused, or had been physically abused)	5-HTTLPR genotype x childhood adversity interaction: EA, OR=...... 5-HTTLPR genotype x childhood adversity interaction: EA, OR=1.49, 95% CI=1.07-2.08, P-value=0.019; AA, OR=0.90, 95% CI=0.60-1.35, P-value=0.62. In combined sample:EA, OR=1.52, 95% CI=1.12-2.06, P-value=0.0069; AA, OR=1.14, 95% CI=0.79-1.64, P-value=0.50. More...	5-HTTLPR genotype x childhood adversity interaction was sign...... 5-HTTLPR genotype x childhood adversity interaction was significantly associated with lifetime PTSD diagnosis in EAs, but not in AAs. The interaction effect was calculated again after adding the diagnosis of major depressive disorder into the logistic regression model as a covariate. Including depression in the model did not change the interaction effect on PTSD. We combined the data from the current study with those from our previous study investigating the interaction effect of 5-HTTLPR and childhood adversity on PTSD risk. With the increased sample size, the power to detect the interaction effect is increased, but the effect in AAs remained non-significant. After adjusting for the effects of substance dependence, the interaction of childhood adversity and 5-HTTLPR genotype on PTSD diagnosis remained largely unchanged. More...	Significant	Xie, P.,2012
5-HTTLPR	SLC6A4	Lifetime PTSD	Childhood adversity, adult traumatic events	2-way interactions, genotype x adult traumatic events intera...... 2-way interactions, genotype x adult traumatic events interaction, European American: OR=2.60; 95% CI=1.19-5.66; P-value=0.02; African American: OR=2.06; 95% CI=1.02-4.14; P-value=0.04; the combination of the 2 populations:OR=1.93; 95% CI=1.17-3.17; P-value=0.01. genotype x childhood adversity interaction: European American: OR=3.29; 95% CI=1.17-9.22; P-value=0.02; African American: OR=1.71; 95% CI=0.81-3.61; P-value=0.16, the combination of the 2 populations: OR=1.81; 95% CI=1.01-3.24; P-value=0.046. The genotype x dual stressful events interaction:European American: OR=2.86; 95% CI=1.50-5.45; P-value=.002; African American: OR=1.88; 95% CI=1.04-3.40; P-value=0.04, the combination of the 2 populations:OR=2.31; 95% CI=1.50-3.56; P-value<.001. More...	5-HTTLPR genotypes interacted with childhood adversity and a...... 5-HTTLPR genotypes interacted with childhood adversity and adult traumatic events to increase risk for developing PTSD. More...	Significant	Xie, P.,2009
5-HTTLPR	SLC6A4	Lifetime PTSD	NTE (number of traumatic events)	LR=7.85, P-value=0.11. LR=7.85, P-value=0.11.	There was a trend toward an interaction between genotype gro...... There was a trend toward an interaction between genotype groups and number of traumatic events experienced. More...	Non-significant	Kolassa, I. T.,2010
APOE_euro4	APOE	Lifetime PTSD	Combat exposure (The Combat Exposure Scale, CES)	Interaction between APOE and combat exposure for lifetime PT...... Interaction between APOE and combat exposure for lifetime PTSD diagnosis: P-value= .0029, with high combat exposure: P-value=.0077. More...	No significant G x E effects were observed within the NHW sa...... No significant G x E effects were observed within the NHW sample. In contrast, significant G x E effects were observed for all three of the main outcomes examined in the NHB sample (all P's < .0083). A significant interaction between APOE and combat exposure was observed for lifetime PTSD diagnosis. For each additional euro4 allele, the odds of having a lifetime PTSD diagnosis increased by 1.61, but only among those with high combat exposure. The rates of lifetime PTSD among the high combat exposure group were 49.3% for participants with no euro4 alleles, 56.4% for those with one euro4 allele, and 92.3% for those with two euro4 alleles (Fig. 1). More...	Significant	Kimbrel, N. A.,2015
rs4606	RGS2	Lifetime PTSD symptoms	PTE/hurricane exposure, Social support	Three-way interaction (genotype by hurricane exposure by soc...... Three-way interaction (genotype by hurricane exposure by social support), lifetime PTSD symptoms: B= 1.12, t=3.71, P-value< .001. More...	Neither of the two-way interactions (genotype by hurricane e...... Neither of the two-way interactions (genotype by hurricane exposure and genotype by social support) was a significant predictor of posthurricane or lifetime PTSD symptoms. The three-way interaction (genotype by hurricane exposure by social support),however, was significantly predictive in both models. The same pattern of results was found when conducting these analyses with the sample restricted to Caucasian participants, and when controlling for the effects of the 5HTTLPR genotype. More...	Significant	Amstadter, A. B.,2009
rs1360780	FKBP5	Memory Performance	Peritraumatic Responses (PDEQ, peritraumatic dissociation)	Association between the new GxE interaction variable and mem...... Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.50, P-value=0.04. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes CC: r=-0.67, P-value=0.03; other genotypes: r=0.03, P-value=0.94. More...	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDEQ (i.e., peritraumatic dissociation) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant	David, A. C.,2012
rs1360780	FKBP5	Memory Performance	Peritraumatic Responses (PDI, peritraumatic distress)	Association between the new GxE interaction variable and mem...... Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.51, P-value=0.03. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes CC: r=-0.69, P-value=0.02; other genotypes: r=0.35, P-value=0.35. More...	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDI (i.e., peritraumatic distress) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant	David, A. C.,2012
rs3800373	FKBP5	Memory Performance	Peritraumatic Responses (PDEQ, peritraumatic dissociation)	Association between the new GxE interaction variable and mem...... Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.51, P-value=0.04. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes AA: r=-0.67, P-value=0.03; other genotypes: r=0.14, P-value=0.75. More...	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDEQ (i.e., peritraumatic dissociation) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant	David, A. C.,2012
rs3800373	FKBP5	Memory Performance	Peritraumatic Responses (PDI, peritraumatic distress)	Association between the new GxE interaction variable and mem...... Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.52, P-value=0.03. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes AA: r=-0.69, P-value=0.02; other genotypes: r=0.39, P-value=0.35. More...	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDI (i.e., peritraumatic distress) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant	David, A. C.,2012
rs9296158	FKBP5	Memory Performance	Peritraumatic Responses (PDEQ, peritraumatic dissociation)	Association between the new GxE interaction variable and mem...... Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.50, P-value=0.04. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes GG: r=-0.67, P-value=0.03; other genotypes: r=0.03, P-value=0.94. More...	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDEQ (i.e., peritraumatic dissociation) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant	David, A. C.,2012
rs9296158	FKBP5	Memory Performance	Peritraumatic Responses (PDI, peritraumatic distress)	Association between the new GxE interaction variable and mem...... Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.51, P-value=0.03. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes GG: r=-0.69, P-value=0.02; other genotypes: r=0.35, P-value=0.35. More...	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDI (i.e., peritraumatic distress) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant	David, A. C.,2012
rs9470080	FKBP5	Memory Performance	Peritraumatic Responses (PDEQ, peritraumatic dissociation)	Association between the new GxE interaction variable and mem...... Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.52, P-value=0.03. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes CC: r=-0.68, P-value=0.03; other genotypes: r=0.04, P-value=0.91. More...	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDEQ (i.e., peritraumatic dissociation) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant	David, A. C.,2012
rs9470080	FKBP5	Memory Performance	Peritraumatic Responses (PDI, peritraumatic distress)	Association between the new GxE interaction variable and mem...... Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.50, P-value=0.04. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes CC: r=-0.69, P-value=0.03; other genotypes: r=0.30, P-value=0.40. More...	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDI (i.e., peritraumatic distress) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant	David, A. C.,2012
5-HTTLPR	SLC6A4	Numbing symptoms	Emotional Abuse	5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=0...... 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=0.44, P-value>0.1; in GTP: F-value=3.57, P-value<0.05. More...	The interaction between 5-HTTLPR and emotional abuse did not...... The interaction between 5-HTTLPR and emotional abuse did not reach statistical significance for the numbing symptom severity among DNHS participants. A significant interaction between 5-HTTLPR genotype and emotional abuse emerged for the numbing symptom clusters among GTP participants. More...	Significant	Walsh, K.,2014
5-HTTLPR	SLC6A4	Numbing symptoms	High exposure	The interaction of 5-HTTPLR S' allele x exposure:B=.20, t=1....... The interaction of 5-HTTPLR S' allele x exposure:B=.20, t=1.49, P-value<=.14 More...	Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was not significantly associated with numbing symptoms. More...	Non-significant	Pietrzak, R. H.,2013
rs2267735	ADCYAP1R1	Past month PTS severity	Childhood maltreatment (CM)	Linear regression model: P-value=0.037. Linear regression model: P-value=0.037.	Results were similar when PTS severity used as outcomes with...... Results were similar when PTS severity used as outcomes with PTSD as outcomes. More...	Significant	Uddin, M.,2013
rs2267735	ADCYAP1R1	Past month PTSD	Childhood maltreatment (CM)	Logistic regression analyses of the effect of ADCAYP1R1 geno...... Logistic regression analyses of the effect of ADCAYP1R1 genotype and CM on PTSD, controlling for age, race, and past month depression: results from interaction effect analyses P-value=0.029, permutation P-value=0.030. More...	Results from interaction effect analyses showed that partici...... Results from interaction effect analyses showed that participants with one versus no "C" alleles at the ADCAYP1R1 rs2267735 locus showed a 17% increased odds of past month PTSD for every one-unit increase in CM score in the logistic regression model. Analyses based on African-American participants only showed similar results. More...	Significant	Uddin, M.,2013
rs1360780	FKBP5	Pearson correlation R value of CTQ Total Score and PSS Scores	Child abuse	CC vs TT group: Z values for difference of correlation coeff...... CC vs TT group: Z values for difference of correlation coefficient=2.46, P-value<0.05;CT vs CC group: Z values for difference of correlation coefficient=2.33, P-value<0.05;TT vs CT group: Z values for difference of correlation coefficient=0.74. More...	They observed significantly higher correlations of CTQ total...... They observed significantly higher correlations of CTQ total score and PSS score between some genotype group of this SNP. More...	Significant	Binder, E. B.,2008
rs3800373	FKBP5	Pearson correlation R value of CTQ Total Score and PSS Scores	Child abuse	AA vs CC group: Z values for difference of correlation coeff...... AA vs CC group: Z values for difference of correlation coefficient=2.59, P-value<0.01;AC vs AA group: Z values for difference of correlation coefficient=2.30, P-value<0.05;CC vs AC group: Z values for difference of correlation coefficient=0.83. More...	They observed significantly higher correlations of CTQ total...... They observed significantly higher correlations of CTQ total score and PSS score between some genotype group of this SNP. More...	Significant	Binder, E. B.,2008
rs9296158	FKBP5	Pearson correlation R value of CTQ Total Score and PSS Scores	Child abuse	AA vs AG group: Z values for difference of correlation coeff...... AA vs AG group: Z values for difference of correlation coefficient=1.17;AG vs GG group: Z values for difference of correlation coefficient=2.35, P-value<0.05;AA vs GG group: Z values for difference of correlation coefficient=3.00, P-value<0.01 More...	They observed significantly higher correlations of CTQ total...... They observed significantly higher correlations of CTQ total score and PSS score between some genotype group of this SNP. More...	Significant	Binder, E. B.,2008
rs9470080	FKBP5	Pearson correlation R value of CTQ Total Score and PSS Scores	Child abuse	CC vs TT group: Z values for difference of correlation coeff...... CC vs TT group: Z values for difference of correlation coefficient=1.9;CT vs CC group: Z values for difference of correlation coefficient=1.20;TT vs CT group: Z values for difference of correlation coefficient=1.03. More...	They observed non-significantly higher correlations of CTQ t...... They observed non-significantly higher correlations of CTQ total score and PSS score between some genotype group of this SNP. More...	Non-significant	Binder, E. B.,2008
rs1006737	CACNA1C	Post Traumatic Growth (PTG)	Hurricane exposure	T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. T4: joint test P-value> 0.05, GxE interaction P-value> 0.05.	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs12944712	CRHR1	Post Traumatic Growth (PTG)	Hurricane exposure	T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. T4: joint test P-value> 0.05, GxE interaction P-value> 0.05.	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs1360780	FKBP5	Post Traumatic Growth (PTG)	Hurricane exposure	T4: joint test P-value=0.0113, GxE interaction P-value=0.537...... T4: joint test P-value=0.0113, GxE interaction P-value=0.537. More...	We found a nominally significant association between FKBP5 a...... We found a nominally significant association between FKBP5 and PTG, with the T allele conferring a higher likelihood of experiencing PTG. The joint effect was driven by a genetic main effect rather than GxE. This result did not withstand correction for multiple testing. More...	Significant	Dunn, E. C.,2014
rs2254298	OXTR	Post Traumatic Growth (PTG)	Hurricane exposure	T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. T4: joint test P-value> 0.05, GxE interaction P-value> 0.05.	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs4606	RGS2	Post Traumatic Growth (PTG)	Hurricane exposure	T4: joint test P-value=0.0044, GxE interaction P-value=0.006...... T4: joint test P-value=0.0044, GxE interaction P-value=0.006. More...	We found a significant association between RGS2 and PTG, whi...... We found a significant association between RGS2 and PTG, which was mainly driven by a cross-over GxE, rather than a main genetic effect. At low levels of Katrina exposure, the G allele (minor allele) was associated with lower PTG (indicating less PTG). However, at moderate and high exposure, the G allele was associated with higher PTG scores (indicating more PTG; refer to Figure 1). This result withstood correction for multiple testing. In this model, the GxE explained 3.9% of the variability in PTG. More...	Significant	Dunn, E. C.,2014
rs53576	OXTR	Post Traumatic Growth (PTG)	Hurricane exposure	T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. T4: joint test P-value> 0.05, GxE interaction P-value> 0.05.	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs6265	BDNF	Post Traumatic Growth (PTG)	Hurricane exposure	T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. T4: joint test P-value> 0.05, GxE interaction P-value> 0.05.	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs9296158	FKBP5	Post Traumatic Growth (PTG)	Hurricane exposure	T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. T4: joint test P-value> 0.05, GxE interaction P-value> 0.05.	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs9470080	FKBP5	Post Traumatic Growth (PTG)	Hurricane exposure	T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. T4: joint test P-value> 0.05, GxE interaction P-value> 0.05.	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
5-HTTLPR	SLC6A4	Post Traumatic Growth (PTG)	Hurricane exposure	T4: joint test P-value> 0.05, GxE interaction P-value= 0.025...... T4: joint test P-value> 0.05, GxE interaction P-value= 0.025. More...	We found a significant association between 5-HTTLPR x exposu...... We found a significant association between 5-HTTLPR x exposure interaction and PTG. More...	Significant	Dunn, E. C.,2014
5-HTTLPR	SLC6A4	Post-hurricane PTSD	High hurricane exposure, Low social support	5-HTTLPR genotype and high hurricane exposure:X2=...... 5-HTTLPR genotype and high hurricane exposure:X2=0.28, df=2, P-value=0.78; 5-HTTLPR genotype and low social support: X2=2.00, df=2, P-value=0.37. The three-way-interaction term for 5-HTTLPR genotype, social support, and hurricane exposure in the adjusted logistic regression model for posthurricane PTSD diagnosis: Wald X2=4.76, df=1, P-value<0.03; odds ratio=4.5, 95% confidence interval [CI]=1.2-17.4. For post hoc analyses, high-risk (N=27, were those with the short/short genotype, low social support, and high hurricane exposure) group vs. low-risk (N=498, were all others) group: odds ratio=20.1, 95% CI=1.4-296.6, P-value=0.03; high-risk group vs. medium risk (N=54, were those with the long/short genotype, low social support, and high hurricane exposure) group: odds ratio=5.0, 95% CI=0.8-30.8, P-value=0.09; medium-risk group vs. low-risk group:odds ratio=4.1, 95% CI=0.6-26.3, P-value=0.14. Secondary analyses were conducted with European Americans only (N=530), three-way interaction term for 5-HTTLPR genotype, social support, and hurricane exposure: odds ratio=4.1, 95% CI=0.9-9.5, P-value=0.07. More...	The two-way interaction terms for genotype by hurricane expo...... The two-way interaction terms for genotype by hurricane exposure and for genotype by social support were not significant for PTSD. The three-way-interaction term for 5-HTTLPR genotype, social support, and hurricane exposure was significant in the adjusted logistic regression model for posthurricane PTSD diagnosis. For post hoc analyses, adults in the high-risk group were significantly more likely to have posthurricane PTSD than those in the low-risk group. The high-risk group showed a tendency toward being more likely to develop PTSD than the medium-risk group. The medium-risk group was not significantly more likely to have PTSD than the low-risk group. Secondary analyses were conducted with European Americans only (N=530). The results paralleled those for the entire cohort. The three-way interaction term for 5-HTTLPR genotype, social support, and hurricane exposure showed a strong tendency for PTSD diagnosis. More...	Significant	Kilpatrick, D. G.,2007
rs4606	RGS2	Post-hurricane PTSD symptoms	PTE/hurricane exposure, Social support	Three-way interaction (genotype by hurricane exposure by soc...... Three-way interaction (genotype by hurricane exposure by social support), posthurricane PTSD symptoms: B=.58, t=2.18, P-value=.029. More...	Neither of the two-way interactions (genotype by hurricane e...... Neither of the two-way interactions (genotype by hurricane exposure and genotype by social support) was a significant predictor of posthurricane or lifetime PTSD symptoms. The three-way interaction (genotype by hurricane exposure by social support),however, was significantly predictive in both models. The same pattern of results was found when conducting these analyses with the sample restricted to Caucasian participants, and when controlling for the effects of the 5HTTLPR genotype. More...	Significant	Amstadter, A. B.,2009
rs25531	SLC6A4	Postshooting PTSD symptoms score (delta DEQ >1 month)	Shooting exposure	White participants only: P-value>0.01. White participants only: P-value>0.01.	Not significant. Not significant.	Non-significant	Mercer, K. B.,2012
5-HTTLPR	SLC6A4	Postshooting PTSD symptoms score (delta DEQ >1 month)	Shooting exposure	White participants only: P-value>0.01. White participants only: P-value>0.01.	Not significant. Not significant.	Non-significant	Mercer, K. B.,2012
5-HTTLPR multimarker	SLC6A4	Postshooting PTSD symptoms score (delta DEQ >1 month)	Shooting exposure	White participants only: P-value>0.01. White participants only: P-value>0.01.	Not significant. Not significant.	Non-significant	Mercer, K. B.,2012
STin2	SLC6A4	Postshooting PTSD symptoms score (delta DEQ >1 month)	Shooting exposure	White participants only: P-value>0.01. White participants only: P-value>0.01.	Not significant. Not significant.	Non-significant	Mercer, K. B.,2012
5-HTTLPR	SLC6A4	Posttraumatic stress (PTS) symptoms 2 years after 9/11	Social constraints	any short allele x social constraints, with controls:b=0.039...... any short allele x social constraints, with controls:b=0.039, SE=0.013, P-value<=0.01 More...	Genotype interacted with social constraints to predict highe...... Genotype interacted with social constraints to predict higher PTS symptoms. Examination of simple slopes revealed a significant positive association between social constraints and PTS symptoms for individuals with an s/lg allele but not for those individuals without an s/lg allele (see Figure 1a). Under low social constraints, genotype was unrelated to PTS symptoms; under high social constraints, respondents with an s/lg allele reported significantly higher PTS symptoms than those with the la/la genotype. More...	Significant	Holman, E. A.,2011
5-HTTLPR	SLC6A4	Posttraumatic stress (PTS) symptoms 3 years after 9/11	Social constraints	any short allele x social constraints, with controls:b=0.032...... any short allele x social constraints, with controls:b=0.032, SE=0.015, P-value<0.05 More...	There was a significant positive association between social ...... There was a significant positive association between social constraints and PTS symptoms for individuals with and without short alleles (Table 3; Figure 1b). Although both simple slopes were significantly different from zero, the significant interaction term indicated that the association between social constraints and PTS symptoms for individuals with an s/lg allele was significantly stronger than the relationship between social constraints and PTS symptoms for la/la individuals. Under low social constraints, genotype was unrelated to PTS symptoms; under high social constraints, respondents with an s/lg allele reported significantly higher PTS symptoms than those with the la/la genotype. More...	Significant	Holman, E. A.,2011
rs1006737	CACNA1C	Post-traumatic stress symptoms (PTS)	Hurricane exposure	Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More...	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs12944712	CRHR1	Post-traumatic stress symptoms (PTS)	Hurricane exposure	Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More...	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs1360780	FKBP5	Post-traumatic stress symptoms (PTS)	Hurricane exposure	Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More...	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs2254298	OXTR	Post-traumatic stress symptoms (PTS)	Hurricane exposure	Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More...	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs4606	RGS2	Post-traumatic stress symptoms (PTS)	Hurricane exposure	Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More...	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs53576	OXTR	Post-traumatic stress symptoms (PTS)	Hurricane exposure	Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More...	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs6265	BDNF	Post-traumatic stress symptoms (PTS)	Hurricane exposure	Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More...	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs9296158	FKBP5	Post-traumatic stress symptoms (PTS)	Hurricane exposure	Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More...	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs9470080	FKBP5	Post-traumatic stress symptoms (PTS)	Hurricane exposure	Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More...	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
5-HTTLPR	SLC6A4	Post-traumatic stress symptoms (PTS)	Hurricane exposure	Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More...	We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More...	Non-significant	Dunn, E. C.,2014
rs4680	COMT	Probability of developing lifetime PTSD	Traumatic load	Interaction of genotype by traumatic load: LR=10.49, P-value...... Interaction of genotype by traumatic load: LR=10.49, P-value=.04. More...	However, the probability of developing lifetime PTSD exhibit...... However, the probability of developing lifetime PTSD exhibited a gene-environment interaction (i.e., an interaction of genotype by traumatic load). More...	Significant	Kolassa, I. T.,2010
rs4680	COMT	Probability of suffering from lifetime PTSD	Gender	Interactions of gender x genotype: P-value > .46. Interactions of gender x genotype: P-value > .46.	There was no significant interactions of gender x genotype o...... There was no significant interactions of gender x genotype on the probability of suffering from lifetime PTSD. More...	Non-significant	Kolassa, I. T.,2010
rs523349	SRD5A2	Proxy-diagnosis of PTSD	Sex	Sex by genotype interaction: N=1,443, T=2.788, P-value=0.005...... Sex by genotype interaction: N=1,443, T=2.788, P-value=0.005. More...	We observed a significant sex by genotype interaction. We observed a significant sex by genotype interaction.	Significant	Gillespie, Charles F.,2013
rs10104133	CHRNA2	PTSD	Smoking status	GxE interactions among NHB participants: P-value=0.04795. GxE interactions among NHB participants: P-value=0.04795.	Nominally significant associations (p<.05) were observed, bu...... Nominally significant associations (p<.05) were observed, but it didn't met multiple-testing threshold. More...	Significant	Kimbrel, N. A.,2015
rs10457838	UST	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs10511822	LINGO2	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs10737854	RGS7	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs1081105	APOE	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value=0.036. More...	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant	Nievergelt, C. M.,2015
rs113712660	TLL1	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs115028822	SERAC1	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs116647843	DTNBP1	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs116897693	CRHR1	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs12442490	RORA	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs12898919	CHRNA5	PTSD	Smoking status	GxE interactions among NHW participants: P-value=0.4988. GxE interactions among NHW participants: P-value=0.4988.	No GxE interactions were statistically significant among NHW...... No GxE interactions were statistically significant among NHW participants. More...	Non-significant	Kimbrel, N. A.,2015
rs1316971	CHRNA4	PTSD	Smoking status	GxE interactions among NHW participants: P-value=0.6343. GxE interactions among NHW participants: P-value=0.6343.	No GxE interactions were statistically significant among NHW...... No GxE interactions were statistically significant among NHW participants. More...	Non-significant	Kimbrel, N. A.,2015
rs1380630	LOC729307	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs138384996	UBE2U	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs139604943	ANK3	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs141129523	RGS2	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs142570922	CYP11B1	PTSD	Childhood trauma	In subjects of Hispanic/Native American, gene and childhood ...... In subjects of Hispanic/Native American, gene and childhood trauma interaction: P-value=0.036. In other descents, gene and childhood trauma interaction: P-value=0.027. More...	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant	Nievergelt, C. M.,2015
rs144782362	SLC6A3	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs148139959	GABRA2	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs148952004	PPM1N	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs16969968	CHRNA5	PTSD	Smoking status	GxE interactions among NHB participants: P-value=0.4467, amo...... GxE interactions among NHB participants: P-value=0.4467, among the NHW participants: P-value=0.172. More...	No GxE interactions were statistically significant among NHB...... No GxE interactions were statistically significant among NHB participants or among the NHW participants. More...	Non-significant	Kimbrel, N. A.,2015
rs174686	COMT	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs17551315	WWC1	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs183063707	TPH2	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs187093517	UBE2E3	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs199563271	PTPRT	PTSD	Childhood trauma	In subjects of African, gene and childhood trauma interactio...... In subjects of African, gene and childhood trauma interaction: P-value=0.020. More...	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant	Nievergelt, C. M.,2015
rs2148269	PRTFDC1	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs2312236	POGK	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs2471320	JHDM1D-AS1	PTSD	Childhood trauma	In subjects of African, gene and childhood trauma interactio...... In subjects of African, gene and childhood trauma interaction: P-value=0.003. More...	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant	Nievergelt, C. M.,2015
rs2565067	CHRNA2	PTSD	Smoking status	GxE interactions among NHWB participants: P-value=0.007639. GxE interactions among NHWB participants: P-value=0.007639.	Nominally significant associations (p<.05) were observed, bu...... Nominally significant associations (p<.05) were observed, but it didn't met multiple-testing threshold. More...	Significant	Kimbrel, N. A.,2015
rs2616978	CSMD1	PTSD	Childhood trauma	In subjects of African, gene and childhood trauma interactio...... In subjects of African, gene and childhood trauma interaction: P-value=0.050. More...	It showed a suggestive interaction effect with childhood tra...... It showed a suggestive interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs28914827	SLC6A4	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs3100127	LGR6	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs363238	SLC18A2	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs4511180	PTPRVP	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs4659395	STMN1	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs4790904	PRKCA	PTSD	Sex	Sex x SNP interaction: P-value >= 0.7. Sex x SNP interaction: P-value >= 0.7.	Sex did not influence the genotype effect on traumatic memor...... Sex did not influence the genotype effect on traumatic memory or PTSD risk. More...	Non-significant	de Quervain, D. J.,2012
rs4838092	LHX2	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs4916008	JAK1	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs4987059	DRD4	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs518425	CHRNA5	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs544437	TPH1	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs588765	CHRNA5	PTSD	Smoking status	GxE interactions among NHW participants: P-value=0.04947. GxE interactions among NHW participants: P-value=0.04947.	Nominally significant associations (p<.05) were observed, bu...... Nominally significant associations (p<.05) were observed, but it didn't met multiple-testing threshold. More...	Significant	Kimbrel, N. A.,2015
rs60646603	CHRNA2	PTSD	Smoking status	GxE interactions among NHB participants: P-value=0.7831. GxE interactions among NHB participants: P-value=0.7831.	No GxE interactions were statistically significant among NHB...... No GxE interactions were statistically significant among NHB participants. More...	Non-significant	Kimbrel, N. A.,2015
rs62275374	LRPAP1	PTSD	Childhood trauma	In subjects of European, gene and childhood trauma interacti...... In subjects of European, gene and childhood trauma interaction: P-value=0.006. More...	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant	Nievergelt, C. M.,2015
rs62516743	CHRNA3	PTSD	Smoking status	GxE interactions among NHW participants: P-value=0.03093. GxE interactions among NHW participants: P-value=0.03093.	Nominally significant associations (p<.05) were observed, bu...... Nominally significant associations (p<.05) were observed, but it didn't met multiple-testing threshold. More...	Significant	Kimbrel, N. A.,2015
rs6314	HTR2A	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs6482463	PRTFDC1	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs6528940	MAGEC1	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs6681010	FASLG	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs6759539	LINC01090	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs6968349	ADCYAP1R1	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs73220799	PLXNC1	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs73679204	CHRNA2	PTSD	Smoking status	GxE interactions among NHB participants: P-value=0.1744. GxE interactions among NHB participants: P-value=0.1744.	No GxE interactions were statistically significant among NHB...... No GxE interactions were statistically significant among NHB participants. More...	Non-significant	Kimbrel, N. A.,2015
rs74572794	CHRNA6	PTSD	Smoking status	GxE interactions among NHW participants: P-value=0.0152. GxE interactions among NHW participants: P-value=0.0152.	Nominally significant associations (p<.05) were observed, bu...... Nominally significant associations (p<.05) were observed, but it didn't met multiple-testing threshold. More...	Significant	Kimbrel, N. A.,2015
rs74939664	ADGRL2	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs75431302	CHRNA3	PTSD	Smoking status	GxE interactions among NHB participants: P-value=0.039. GxE interactions among NHB participants: P-value=0.039.	Nominally significant associations (p<.05) were observed, bu...... Nominally significant associations (p<.05) were observed, but it didn't met multiple-testing threshold. More...	Significant	Kimbrel, N. A.,2015
rs75924850	DRD2	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs77929608	SRD5A2	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs78826942	FRMD5	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs79485117	KDM7A	PTSD	Childhood trauma	In subjects of African, gene and childhood trauma interactio...... In subjects of African, gene and childhood trauma interaction: P-value=0.027. More...	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant	Nievergelt, C. M.,2015
rs79590198	NR3C1	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value=0.022. More...	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant	Nievergelt, C. M.,2015
rs80087508	CHRNA5	PTSD	Smoking status	GxE interactions among NHB participants: P-value=0.9147. GxE interactions among NHB participants: P-value=0.9147.	No GxE interactions were statistically significant among NHB...... No GxE interactions were statistically significant among NHB participants. More...	Non-significant	Kimbrel, N. A.,2015
rs8036584	CHRNA7	PTSD	Smoking status	GxE interactions among NHW participants: P-value=0.5851. GxE interactions among NHW participants: P-value=0.5851.	No GxE interactions were statistically significant among NHW...... No GxE interactions were statistically significant among NHW participants. More...	Non-significant	Kimbrel, N. A.,2015
rs8042149	RORA	PTSD	NTE (number of traumatic events)	Logistic regression model that included NTE (number of traum...... Logistic regression model that included NTE (number of traumatic events) and rs8042149: SNP and NTE interaction, P-value=0.4576. More...	A further logistic model indicated that NTE and SNP interact...... A further logistic model indicated that NTE and SNP interaction was not significant More...	Non-significant	Logue, M. W.,2013
rs9366890	FKBP5	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
rs9545302	LINC01080	PTSD	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant	Nievergelt, C. M.,2015
5-HTTLPR	SLC6A4	PTSD	Average level of war zone stressors	MRM analyses: genotype: b=0.21, t=2.08, P-value<0.05. Separa...... MRM analyses: genotype: b=0.21, t=2.08, P-value<0.05. Separately for S' carriers: b=0.28, t=4.01, P-value<0.0001. Separately for L' homozygote: b=0.07, t=0.86, P-value>0.39. More...	MRM analyses revealed significant interactions between 5-HTT...... MRM analyses revealed significant interactions between 5-HTTLPR genotype and average level of war zone stressors during deployment for all three measures of war zone stress reactions. For L' homozygotes, higher levels of average stress reported in the ?eld did not predict higher symptoms, In contrast, and consistent with our hypothesis, S' carriers responded to higher levels of average stress with higher levels of PTSD symptoms. More...	Significant	Telch, M. J.,2015
5-HTTLPR	SLC6A4	PTSD	Average level of war zone stressors, Race	Three way interaction: p-values ranged between 0.17 and 0.4...... Three way interaction: p-values ranged between 0.17 and 0.47 More...	The race x war zone stressors x 5-HTTLPR genotype interactio...... The race x war zone stressors x 5-HTTLPR genotype interaction for PTSD was not significant, indicating that the observed war zone stressors x 5-HTTLPR genotype interactions were not influenced by soldiers'race. More...	Non-significant	Telch, M. J.,2015
5-HTTLPR	SLC6A4	PTSD	Change in stress	MRM analyses: genotype: b=-0.14, P-value>0.05 MRM analyses: genotype: b=-0.14, P-value>0.05	Not significant effect. Not significant effect.	Non-significant	Telch, M. J.,2015
5-HTTLPR	SLC6A4	PTSD	Earthquake exposure	Interaction effect of genotype and earthquake exposure: OR=4...... Interaction effect of genotype and earthquake exposure: OR=4.304, 95%CI=1.285-14.414, P-value=0.018. More...	The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was statistically significant. More...	Significant	Tian, Y.,2015
5-HTTVNTR	SLC6A4	PTSD	Earthquake exposure	Interaction effect of genotype and earthquake exposure: OR=4...... Interaction effect of genotype and earthquake exposure: OR=4.612, 95%CI=1.215-17.505, P-value=0.025. More...	The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was statistically significant. More...	Significant	Tian, Y.,2015
APOE_euro2/euro3/euro4	APOE	PTSD	Harmful drinking	In the interaction effect model, the harmful drinking x abse...... In the interaction effect model, the harmful drinking x absence of APOE euro2-allele interaction: P-value=0.005, adjusted OR=2.56, 95%CI=1.32-4.97. Post hoc stratified analysis in euro2-allele noncarriers: P-value= .001, OR=2.54, 95%CI=1.44-4.46, in euro2-allele carriers: P-value=.271, OR=1.18, 95%CI=.29-4.83. More...	In the interaction effect model, only the harmful drinking x...... In the interaction effect model, only the harmful drinking x absence of APOE euro2-allele interaction was statistically significant. Post hoc stratified analysis also revealed that harmful drinking was associated with an increased risk of PTSD in euro2-allele noncarriers but not in euro2-allele carrier. More...	Significant	Kim, T. Y.,2013
DRD2_Taq 1	DRD2	PTSD	Earthquake exposure	Interaction effect of genotype and earthquake exposure: OR=1...... Interaction effect of genotype and earthquake exposure: OR=1.139, 95%CI=0.273-4.746, P-value=0.858. More...	The interaction effects of this genotype with earthquake exp...... The interaction effects of this genotype with earthquake exposure was not statistically significant. More...	Non-significant	Tian, Y.,2015
rs9296158	FKBP5	PTSD (Total PCL-C score)	Childhood maltreatment (CM)	When controlling for ethnicity and other covariates, rs92961...... When controlling for ethnicity and other covariates, rs9296158 with child maltreatment interaction on PTSD: P-value=0.552. Analysis in the Chhetri-only group: P-value=0.117. More...	When controlling for ethnicity and other covariates, rs92961...... When controlling for ethnicity and other covariates, rs9296158 also showed a significant interaction effect with child maltreatment on PTSD. Analysis in the Chhetri-only group showed similar results. More...	Non-significant	Kohrt, B. A.,2015
rs4680	COMT	PTSD category B symptom	Race	Wald X2=2.94, P-value=0.23 Wald X2=2.94, P-value=0.23	Subsequent analyses within symptom clusters demonstrated tha...... Subsequent analyses within symptom clusters demonstrated that the genotype by race interaction was not significant for Criterion B symptoms. More...	Non-significant	Humphreys, K. L.,2014
5-HTTLPR	SLC6A4	PTSD category B symptom score	NTE (number of traumatic events)	No detail information No detail information	No statistically significant interactions emerged when perfo...... No statistically significant interactions emerged when performing the analyses for B and C criteria irrespective of the trauma threshold. More...	Non-significant	Grabe, H. J.,2009
rs4680	COMT	PTSD category C symptom	Race	Wald X2=4.22, P-value=0.12 Wald X2=4.22, P-value=0.12	Subsequent analyses within symptom clusters demonstrated tha...... Subsequent analyses within symptom clusters demonstrated that the genotype by race interaction was not significant for Criterion C symptoms. More...	Non-significant	Humphreys, K. L.,2014
5-HTTLPR	SLC6A4	PTSD category C symptom score	NTE (number of traumatic events)	No detail information No detail information	No statistically significant interactions emerged when perfo...... No statistically significant interactions emerged when performing the analyses for B and C criteria irrespective of the trauma threshold. More...	Non-significant	Grabe, H. J.,2009
rs4680	COMT	PTSD category D symptom	Race	Wald X2=10.47, P-value=0.005 Wald X2=10.47, P-value=0.005	A significant genotype by race interaction was found for Cri...... A significant genotype by race interaction was found for Criterion D symptoms. Given the repeated post-hoc tests, the family wise alpha level was adjusted to p<0.017 (dividing 0.05 by 3 [for the three symptom clusters]) to determine statistical significance. Even following this adjustment, the above-cited p value for the interaction of genotype and race for Criterion D symptoms remained statistically significant. More...	Significant	Humphreys, K. L.,2014
5-HTTLPR	SLC6A4	PTSD category D symptom score	NTE (number of traumatic events)	RERI for the continuous genetic model (zero, one, or two LA ...... RERI for the continuous genetic model (zero, one, or two LA alleles) was 1.2 (95% CI=0.5-2.8, P-value<0.05). More...	Statistically significant interactions was found between num...... Statistically significant interactions was found between number of traumatic events and 5-HTTLPR genotype. More...	Significant	Grabe, H. J.,2009
5-HTTLPR	SLC6A4	PTSD diagnosis	NTE (number of traumatic events)	Three as a cutoff point for the number of traumas: RERI was ...... Three as a cutoff point for the number of traumas: RERI was 1.3 for the unadjusted model and 1.5 (95% CI=0.5-4.3, P-value<0.05) for the fully adjusted model. Four as a cutoff point for the number of traumas: RERI increased to 1.8 (95% CI=1.6-31.7, P-value<0.05). When two was used as a cutoff point for the number of traumas, no statistically significant interactions emerged. For the final model, RERI was 3.3. More...	Statistically significant interactions was found between num...... Statistically significant interactions was found between number of traumatic events and 5-HTTLPR genotype. More...	Significant	Grabe, H. J.,2009
5-HTTLPR	SLC6A4	PTSD severity	Emotional Abuse	5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=2...... 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=2.67, P-value<0.1; in GTP: F-value=2.97, P-value<0.1. More...	The interaction between 5-HTTLPR and emotional abuse did not...... The interaction between 5-HTTLPR and emotional abuse did not reach statistical significance for total PTSD symptom severity among DNHS or GTP participants. More...	Non-significant	Walsh, K.,2014
5-HTTLPR	SLC6A4	PTSD status	Combat exposure	Logistic regression model 5-HTTLPR x combat exposure interac...... Logistic regression model 5-HTTLPR x combat exposure interaction term, on the NHB sample: P-value=.65; on the NHW sample: P-value=.51. More...	A second logistic regression model was conducted on the NHB ...... A second logistic regression model was conducted on the NHB sample to test for potential 5-HTTLPR x combat exposure effects on PTSD status. The results from this model were highly similar to the first. 5-HTTLPR, civilian trauma, combat trauma, and PC1 all continued to have significant main effects on PTSD; however, no other variable in the model, including the 5-HTTLPR x combat exposure interaction term, was significant. Similar results were obtained from the second logistic regression model that tested for 5-HTTLPR x combat exposure effects on PTSD among NBW sample. More...	Non-significant	Liu, Y.,2015
rs110402	CRHR1	PTSD Symptom Severity	Child abuse	No available detail information. No available detail information.	It showed a non-significant interaction effect with child ab...... It showed a non-significant interaction effect with child abuse or non-child abuse trauma exposure on PTSD symptom severity. More...	Non-significant	Binder, E. B.,2008
rs2267735	ADCYAP1R1	PTSD symptom severity	Trauma Load	When stratifying by sex, in females (N=858) ADCYAP1R1 genoty...... When stratifying by sex, in females (N=858) ADCYAP1R1 genotype x trauma interaction: t=3.46, P-value=0.0006, in males (N=301) ADCYAP1R1 genotype x trauma interaction: P-value=0.47. The genotype x trauma interaction in females adjusting for age: t= 3.44, P-value=0.0006, income: t= 3.21, P-value=0.001, past substance abuse: t=3.56, P-value=0.0004, depression severity: t=2.30, P-value=0.02, or childhood trauma load: t=3.76, P-value=0.0002, and all five:t=2.50, P-value=0.01. In the combined sample, trauma x genotype interaction in females (N=1424): t=4.30, P-value<0.0001; in males (N=646): P-value> 0.1, when adjusting for age: t=4.29, P-value< 0.0001, income: t=4.44, P-value< 0.0001, past substance abuse: t=4.31, P-value< 0.0001, depression severity: t=2.57, P-value=0.01, or childhood trauma load: t=4.16, P-value< 0.0001, and all five: t=2.85, P= 0.004. More...	We did find a genotype x trauma interaction that differed by...... We did find a genotype x trauma interaction that differed by sex. As shown in Figure 1B, the C allele is more associated with PTSD symptom severity for females with high trauma load. In males on the other hand, there was no ADCYAP1R1 genotype x trauma interaction. The genotype x trauma interaction in females remained when adjusting for age, income, past substance abuse, depression severity, or childhood trauma load, and all five. Moreover, when controlling for comorbid PTSD symptom severity, we did not find a significant association of ADCYAP1R1 genotype on depression severity nor a trauma x genotype interaction. The main finding of an ADCYAP1R1 genotype x trauma interaction on PTSD symptom severity was tested for statistical robustness and verified with permutation and bootstrapping methods. In the combined sample, we found a strong association between PTSD symptom severity and a trauma x genotype interaction in females but not males. Thus, at higher trauma levels, carriers of the C allele are associated with PTSD symptom severity. Again, the genotype x trauma interaction in females remained when adjusting for age, income, past substance abuse, depression severity, or childhood trauma load, and all five. More...	Significant	Almli, L. M.,2013
rs242924	CRHR1	PTSD Symptom Severity	Child abuse	No available detail information. No available detail information.	It showed a non-significant interaction effect with child ab...... It showed a non-significant interaction effect with child abuse or non-child abuse trauma exposure on PTSD symptom severity. More...	Non-significant	Binder, E. B.,2008
rs7209436	CRHR1	PTSD Symptom Severity	Child abuse	No available detail information. No available detail information.	It showed a non-significant interaction effect with child ab...... It showed a non-significant interaction effect with child abuse or non-child abuse trauma exposure on PTSD symptom severity. More...	Non-significant	Binder, E. B.,2008
APOE_euro4	APOE	PTSD symptom severity	Combat exposure (The Combat Exposure Scale, CES)	APOE and combat exposure interaction to predict current PTSD...... APOE and combat exposure interaction to predict current PTSD symptom severity: P-value= .0009, with high combat exposure: P-value= .0011. More...	No significant G x E effects were observed within the NHW sa...... No significant G x E effects were observed within the NHW sample. APOE and combat exposure also interacted to predict current PTSD symptom severity. Again, as the number of euro4 alleles increased, the mean severity score on the DTS increased by 10.25 points, but only among those with high combat exposure. More...	Significant	Kimbrel, N. A.,2015
APOE_euro4	APOE	PTSD Symptomatology	Combat exposure	Primary anlalyses, N=172, interaction between combat exposur...... Primary anlalyses, N=172, interaction between combat exposure and APOE genotype: B=0.529, P-value=0.014 (signif from GEE). Using only White, non-Hispanic participants: P-value=0.008. More...	The interaction of combat exposure and apoE genotype was sig...... The interaction of combat exposure and apoE genotype was significant in primary anlalyses. The interaction between combat exposure and apoE genotype remained a significant predictor of the number of PTSD symptoms using only White, non-Hispanic participants. More...	Significant	Lyons, M. J.,2013
rs2400707	ADRB2	PTSD symptoms	Adverse childhood event (ACE)	Linear regression model controlling for adult trauma exposur...... Linear regression model controlling for adult trauma exposure, the SNP x ACE interaction: mean unstandardized estimate B= 3.07, SD=0.69, beta=0.243, t=4.48, P-value=1.02-5e. Stratification of the sample by ACEs in persons with 2 or more reported categories of ACEs:n=93, mean B =?6.44, SD=2.08, t=?3.10, P-value=.003. Secondary analysis of binary logistic regression of PTSD caseness: rs2400707 x ACE interaction: OR=0.54, P-value=5.16-4e. Addition of PCs of rs2400707: P-value=1.11-5e. The rs2407007 x ACE interaction in the association with PTSD symptoms in the Grady Trauma Project: mean B=1.80, SD=0.54, t=3.328, P-value=.0009; when using robust standard errors: mean B=1.81, SD=0.60, t=3.02, P-value=.0026 after controlling for sex and adult trauma exposure: mean B=1.58, SD=0.50, t=3.15, P-value=.0017 and after controlling for the 10 PCs: mean B=1.55, SD=0.51, t=3.06, P-value=.0022. In persons with 2 or more reported ACEs: n=197, mean B=?5.34, SD=1.35, t=3.95, P-value=.00011). More...	Significant associations were detected for the SNP x ACE int...... Significant associations were detected for the SNP x ACE interaction term in rs2400707. Permutation analysis of the SNP x ACE interaction term further confirmed a significant association with rs2400707 (P-value < .05 corrected for multiple comparisons). As shown in Figure 1A, rs2400707 AA homozygotes demonstrated lower levels of PTSD symptoms in the presence of 2 or more categories of reported childhood adversity in the discovery cohort. Stratification of the sample by ACEs showed an effect of rs2400707 only in persons with 2 or more reported categories of ACEs. Although our primary focus was on continuous measures of PTSD severity, a secondary analysis of binary logistic regression of PTSD caseness confirmed an rs2400707 x ACE interaction, indicating that the A allele is protective in terms of adult PTSD symptoms on categorical PTSD diagnosis. Addition of PCs did not alter the significant association of rs2400707. The rs2407007 x ACE interaction in the association with PTSD symptoms in the Grady Trauma Project remained significant when using robust standard errors after controlling for sex and adult trauma exposure and after controlling for the 10 PCs. Again, an effect of rs2400707 was found only in persons with 2 or more reported ACEs. We tested the same model (linear regression of SNP, ACEs, adult trauma, and SNP x ACE and SNP x adult trauma interaction terms) in the combined data set (adjusting symptom severity measures to the same scale) of both the discovery and replication cohorts. We found that the rs2400707 x ACE interaction term had a mean. More...	Significant	Liberzon, I.,2014
rs6265	BDNF	PTSD symptoms	Immediate loss and disruption, social support	GxExSS interaction:beta=-.27, P-value=.01 (emerged for the s...... GxExSS interaction:beta=-.27, P-value=.01 (emerged for the stressor of immediate loss/disruption). More...	When analyses were restricted to the youth who completed the...... When analyses were restricted to the youth who completed the social support measure, a significant GxExSS interaction emerged for the stressor of immediate loss/disruption; this interaction is depicted in Fig. 1. As expected, under the condition of low social support, there was a stronger association between stress levels and PTSD symptoms for youth with the met allele than for youth without the met allele. In contrast, under conditions of high support, youth with the met allele fared significantly better than youth without the met allele, especially among those reporting high levels of stress. More...	Significant	La Greca, A. M.,2013
rs6265	BDNF	PTSD symptoms	Ongoing loss and disruption	GxE interaction for ongoing loss and disruption: beta=.21, P...... GxE interaction for ongoing loss and disruption: beta=.21, P-value=.04; for the youth with the presence of the met allele: b=6.65, t(108)=3.34, P-value<.001; for youth without this allele: b=2.04, t(108)=1.84, non-significant. More...	For BDNF, and for the outcome of PTSD symptoms (Table 2), a ...... For BDNF, and for the outcome of PTSD symptoms (Table 2), a significant GxE interaction was obtained for ongoing loss and disruption. As expected, the association between ongoing loss and disruption and children's PTSD symptoms was stronger for the youth with the presence of the met allele than for youth without this allele. More...	Significant	La Greca, A. M.,2013
5-HTTLPR	SLC6A4	PTSD symptoms	Environmental stressors	P-value>.10 P-value>.10	There was little support for a GxE interaction in predicting...... There was little support for a GxE interaction in predicting children's symptoms of PTSD or depression. For the outcome of PTSD symptoms, no interactions approached significance (based on p<.10). More...	Non-significant	La Greca, A. M.,2013
rs6010719	OPRL1	PTSD symptoms	Childhood trauma	F=6.4; P-value<0.005; after controlling for age, sex, and su...... F=6.4; P-value<0.005; after controlling for age, sex, and substance abuse: F=6.9; P-value<=0.001. More...	SNP rs6010719 was associated with increased PTSD symptoms in...... SNP rs6010719 was associated with increased PTSD symptoms in individuals exposed to moderate to severe child abuse, after controlling for age, sex, and substance abuse rs6010719 remained significant in the interaction. More...	Significant	Andero, R.,2013
rs4680	COMT	PTSD symptoms (combined scores for severity and frequency)	PTE (potentially traumatizing events)	Regression 1 (trauma and COMT variation), Block 2 main effec...... Regression 1 (trauma and COMT variation), Block 2 main effects with interactions: PTE and Val/Met genotype interaction, Wald X2=10.08, df=2, P-value=0.007; PTE and Val/Val interaction, b=0.118, SE=0.052, Wald X2=5.08, df=1, P-value=0.024; PTE and Met/Met interaction, b=0.107, SE=0.040, Wald X2=7.18, df=1, P-value=0.007. Regression 2 (interaction of trauma and COMT variation with pre-trauma personality factors), controlling for internalizing and externalizing, Block 2 main effects with interactions: PTE and Val/Met genotype interaction, Wald X2=11.74, df=2, P-value=0.003; PTE and Val/Val interaction, b=0.141, SE=0.055, Wald X2=6.65, df=1, P-value=0.010; PTE and Met/Met interaction, b=0.113, SE=0.040, Wald X2=8.17, df=1, P-value=0.004. More...	Block 2 of that regression 1 tests the interaction between t...... Block 2 of that regression 1 tests the interaction between trauma and genotype. A significant gene-environment interaction indicated that the three COMT genotypes had different patterns of response to trauma. Regression 2 shows that the interaction between genotype and level of lifetime trauma remained significant when controlling for Internalizing and Externalizing. More...	Significant	Clark, R.,2013
rs4680	COMT	PTSD symptoms (combined scores for severity and frequency)	Traumatic load (it was divided into trauma experienced prior to deployment (named predeployment trauma) and trauma experienced during deployment (named deployment-based trauma))	Regression 3 (interaction of trauma and COMT variation consi...... Regression 3 (interaction of trauma and COMT variation considering time of trauma), Block 2 main effects with interaction, controlling for internalizing and externalizing, Val/Met genotype and predeployment trauma interaction: Wald X2=5.60, df=2, P-value=0.061; Val/Val genotype and predeployment trauma interaction: b=0.170, SE=0.136, Wald X2=1.56, df=1, P-value=0.212; Met/Met genotype and predeployment trauma interaction: b=0.186, SE=0.082, Wald X2=5.19, df=1, P-value=0.023; Val/Met genotype and deployment-based trauma interaction: Wald X2=3.09, df=2, P-value=0.213; Val/Val genotype and deployment-based trauma interaction: b=0.128, SE=0.087, Wald X2=2.17, df=1, P-value=0.141; Met/Met genotype and deployment-based trauma interaction: b=0.077, SE=0.056, Wald X2=1.86, df=1, P-value=0.173; More...	The interaction between trauma load and COMT was a significa...... The interaction between trauma load and COMT was a significant predictor of PTSD symptoms. Those with the heterozygous genotype (Val/Met) showed fewer symptoms associated with trauma exposure compared to those with either homozygous genotype. This interaction remained significant after controlling for other risk factors for PTSD, including personality dimensions of Internalizing and Externalizing. More...	Significant	Clark, R.,2013
rs1503292	TLL1	PTSD symptoms (mPSS)	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0....... Linear regression, GxE P-value(standard regression model)=0.39, GxE P-value(adjusted with robust standard errors with R package geepack)=0.44. More...	We haven't found a significant genotype and environment inte...... We haven't found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Non-significant	Almli, L. M.,2014
rs382903	COBL	PTSD symptoms (mPSS)	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0....... Linear regression, GxE P-value(standard regression model)=0.0003, GxE P-value(adjusted with robust standard errors with R package geepack)=0.001. More...	We found a significant genotype and environment interaction ...... We found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Significant	Almli, L. M.,2014
rs406001	COBL	PTSD symptoms (mPSS)	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0....... Linear regression, GxE P-value(standard regression model)=0.0006, GxE P-value(adjusted with robust standard errors with R package geepack)=0.002. More...	We found a significant genotype and environment interaction ...... We found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Significant	Almli, L. M.,2014
rs450378	COBL	PTSD symptoms (mPSS)	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0....... Linear regression, GxE P-value(standard regression model)=0.008, GxE P-value(adjusted with robust standard errors with R package geepack)=0.02. More...	We found a significant genotype and environment interaction ...... We found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Significant	Almli, L. M.,2014
rs6812849	TLL1	PTSD symptoms (mPSS)	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0....... Linear regression, GxE P-value(standard regression model)=0.45, GxE P-value(adjusted with robust standard errors with R package geepack)=0.45. More...	We haven't found a significant genotype and environment inte...... We haven't found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Non-significant	Almli, L. M.,2014
rs7691872	TLL1	PTSD symptoms (mPSS)	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0....... Linear regression, GxE P-value(standard regression model)=0.11, GxE P-value(adjusted with robust standard errors with R package geepack)=0.13. More...	We haven't found a significant genotype and environment inte...... We haven't found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Non-significant	Almli, L. M.,2014
rs1334894	FKBP5	PTSD Symptoms (PSS scores)	Child abuse	No available detail information. No available detail information.	No significant signals was observed about this SNP's interac...... No significant signals was observed about this SNP's interaction of FKBP5 with child abuse to predict PTSD symptoms. More...	Non-significant	Binder, E. B.,2008
rs1360780	FKBP5	PTSD Symptoms (PSS scores)	Child abuse	Interaction of it with child abuse level (to predict PTSD sy...... Interaction of it with child abuse level (to predict PTSD symptoms),an interaction P-value<.002 (after correcting for multiple tesing) . After adjusting for variables (controlling for BDI score as a continuous measure of depression symptoms or the 4-level non-child abuse trauma variable in addtion to age and sex) , the interaction P-value=0.07. More...	We identified the SNP that showed significant interactions w...... We identified the SNP that showed significant interactions with child abuse afterc orrecting for multiple testing. More...	Significant	Binder, E. B.,2008
rs3800373	FKBP5	PTSD Symptoms (PSS scores)	Child abuse	Interaction of it with child abuse level (to predict PTSD sy...... Interaction of it with child abuse level (to predict PTSD symptoms),an interaction P-value<.002 (after correcting for multiple tesing) . More...	We identified the SNP that showed significant interactions w...... We identified the SNP that showed significant interactions with child abuse afterc orrecting for multiple testing. After adjusting for variables (controlling for BDI score as a continuous measure of depression symptoms or the 4-level non-child abuse trauma variable in addtion to age and sex) , the interaction terms of child abuse and rs3800373 remained significant. More...	Significant	Binder, E. B.,2008
rs4713916	FKBP5	PTSD Symptoms (PSS scores)	Child abuse	No available detail information. No available detail information.	No significant signals was observed about this SNP's interac...... No significant signals was observed about this SNP's interaction of FKBP5 with child abuse to predict PTSD symptoms. More...	Non-significant	Binder, E. B.,2008
rs737054	FKBP5	PTSD Symptoms (PSS scores)	Child abuse	No available detail information. No available detail information.	No significant signals was observed about this SNP's interac...... No significant signals was observed about this SNP's interaction of FKBP5 with child abuse to predict PTSD symptoms. More...	Non-significant	Binder, E. B.,2008
rs9296158	FKBP5	PTSD Symptoms (PSS scores)	Child abuse	Interaction of it with child abuse level (to predict PTSD sy...... Interaction of it with child abuse level (to predict PTSD symptoms),an interaction P-value<.0004 (after correcting for multiple tesing). More...	We identified it as the the most significant SNP in the inte...... We identified it as the the most significant SNP in the interaction of KFBP5 polymorphisms with child abuse to predict PTSD symptoms. After adjusting for variables (controlling for BDI score as a continuous measure of depression symptoms or the 4-level non-child abuse trauma variable in addtion to age and sex) , the interaction terms of child abuse and rs9296158 remained significant. More...	Significant	Binder, E. B.,2008
rs9470080	FKBP5	PTSD Symptoms (PSS scores)	Child abuse	Interaction of it with child abuse level (to predict PTSD sy...... Interaction of it with child abuse level (to predict PTSD symptoms),an interaction P-value<.002 (after correcting for multiple tesing). After adjusting for variables (controlling for BDI score as a continuous measure of depression symptoms or the 4-level non-child abuse trauma variable in addtion to age and sex) , the interaction P-value=0.06. More...	We identified the SNP that showed significant interactions w...... We identified the SNP that showed significant interactions with child abuse afterc orrecting for multiple testing. More...	Significant	Binder, E. B.,2008
rs992105	FKBP5	PTSD Symptoms (PSS scores)	Child abuse	No available detail information. No available detail information.	No significant signals was observed about this SNP's interac...... No significant signals was observed about this SNP's interaction of FKBP5 with child abuse to predict PTSD symptoms. More...	Non-significant	Binder, E. B.,2008
5-HTTLPR multimarker	SLC6A4	Reexperiencing (2-4 week delta DEQ)	Shooting exposure	White participants only:P-value=0.1. White participants only:P-value=0.1.	Reexperiencing symptoms were not significantly different. Reexperiencing symptoms were not significantly different.	Non-significant	Mercer, K. B.,2012
5-HTTLPR	SLC6A4	Reexperiencing symptoms	Emotional Abuse	5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=4...... 5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=4.08, P-value<0.05; in GTP: F-value=3.56, P-value<0.05. In GTP, any S allele also interacted with emotional abuse to predict re-experiencing symptoms, F(1,538) = 3.76, P-value= .053. More...	A significant interaction was observed between 5-HTTLPR geno...... A significant interaction was observed between 5-HTTLPR genotype and emotional abuse on worst reexperiencing symptom severity after controlling for age and sex among DNHS participants. A significant interaction between 5-HTTLPR genotype and emotional abuse emerged for the reexperiencing symptom clusters among GTP participants. More...	Significant	Walsh, K.,2014
5-HTTLPR	SLC6A4	Reexperiencing symptoms	High exposure	The interaction of 5-HTTPLR S' allele x exposure:B=.35, t=4....... The interaction of 5-HTTPLR S' allele x exposure:B=.35, t=4.56, P-value<<.001 More...	Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was significantly associated with re-experiencing symptoms. More...	Significant	Pietrzak, R. H.,2013
5-HTTLPR	SLC6A4	Severity of PTSD symptoms	High exposure	The interaction of 5-HTTPLR genotype x exposure: B=0.40, P-v...... The interaction of 5-HTTPLR genotype x exposure: B=0.40, P-value<0.001. More...	Results of these analyses revealed that after adjustment for...... Results of these analyses revealed that after adjustment for age, sex, and ancestral proportion scores, the interaction of 5-HTTPLR genotype x exposure was significantly associated with severity of Ike-related PTSD. More...	Significant	Pietrzak, R. H.,2013
rs4680	COMT	Total PTSD symptoms	Race	Wald X2=15.45, P-value<0.001 Wald X2=15.45, P-value<0.001	A significant COMT genotype by race interaction was found in...... A significant COMT genotype by race interaction was found in predicting total PTSD symptoms. More...	Significant	Humphreys, K. L.,2014
rs523349	SRD5A2	Total PTSD symptoms	Childhood trauma questionnaire (CTQ)	The interaction between SRD5A2 -V89L and CTQ: P-value=0.052. The interaction between SRD5A2 -V89L and CTQ: P-value=0.052.	The interaction between SRD5A2 -V89L and CTQ when predicting...... The interaction between SRD5A2 -V89L and CTQ when predicting PSS score in males was suggestive but not significant. More...	Non-significant	Gillespie, Charles F.,2013
rs523349	SRD5A2	Total PTSD symptoms	Sex	Interaction between sex and genotype: N=1,443, T=3.206, P-va...... Interaction between sex and genotype: N=1,443, T=3.206, P-value=0.0014. More...	We observed a significant interaction between sex and genoty...... We observed a significant interaction between sex and genotype, suggesting a sex-dependent association between SRD5A2-V89L and PSS. More...	Significant	Gillespie, Charles F.,2013
rs523349	SRD5A2	Total PTSD symptoms	Traumatic events inventory (TEI)	Interaction between SRD5A2 -V89L and TEI in males:P-value>0....... Interaction between SRD5A2 -V89L and TEI in males:P-value>0.1. More...	We did not observe an interaction between SRD5A2 -V89L and T...... We did not observe an interaction between SRD5A2 -V89L and TEI when predicting PSS score in males. More...	Non-significant	Gillespie, Charles F.,2013