SNP Report
Basic Info
| Name | rs2190242 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 7:30669859 - 30669859(+) | ||
| Variant Seq | A | ||
| Ancestral Allele | A | ||
| Ref Seq | C | ||
| Minor Allele Frequence | 0.327676 | ||
| Annotation | intron_variant; NMD_transcript_variant | ||
| Variant Effect | intron_variant(ENST00000348438, ENST00000506074, ENST00000471646, ENST00000341843, ENST00000452278); NMD_transcript_variant(ENST00000452278) | ||
| SIFT Annotation | deleterious | ||
| SIFT Variant Effect | deleterious(ENST00000341843, ENST00000348438, ENST00000471646, ENST00000506074) | ||
| PolyPhen Annotation | possibly_damaging; probably_damaging | ||
| PolyPhen Variant Effect | possibly_damaging(ENST00000348438, ENST00000471646, ENST00000506074); probably_damaging(ENST00000341843) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription | ||
| No. of Marker's Association Results | 2 (Positive: 2; Negative: 0; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Wolf, E. J.,2013 | Latent PTSD Severity | Structural equation modeling: unstandardized B= -1.96, P-va...... Structural equation modeling: unstandardized B= -1.96, P-value= 0.01. In women: unstandardized B= -4.26, P-value= 0.001. In men: unstandardized B= -0.50, P-value= 0.57 More... | The SNP showed a significant association with PTSD severity,...... The SNP showed a significant association with PTSD severity, remained significant after correction for multiple testing. These associations to be significant in women but not men. More... | Significant |
| Wolf, E. J.,2013 | PTSD diagnosis | X2=12.06 OR=0.58, 95% CI: 0.42-0.79, P-value unco...... X2=12.06 OR=0.58, 95% CI: 0.42-0.79, P-value uncorrected=0.0005, P-value corrected=0.01. In women: OR= 0.35, 95% CI: 0.20-0.62, P-value= 0.0002, corrected P-value= .004; In men: OR= 0.75, 95% CI: 0.50-1.13, P-value=0.17. More... | It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, the minor allele (C) of rs2190242 was associated with reduced risk for PTSD, remained significant after correction for multiple testing. These associations to be significant in women but not men. More... | Significant |
G*E study related association result (count: 1)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Wolf, E. J.,2013 | Latent PTSD Severity | Lifetime trauma exposure | Structural equation modeling: unstandardized B= 0.15, P-valu...... Structural equation modeling: unstandardized B= 0.15, P-value= 0.31. More... | Trauma exposure did not interact with the SNP to predict PTS...... Trauma exposure did not interact with the SNP to predict PTSD severity. More... | Non-significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CRHR2 | corticotropin releasing hormone receptor 2 | 7p14.3 | 2(2/0/0) |
SNPs in LD with rs2190242 (count: 0)
SNP related eQTL (count: 1)