Gene Report

Basic Info

Approved Symbol	ADRB2
Previous Symbol	ADRB2R
Symbol Alias	"ADRBR\|BAR\|B2AR"
Approved Name	adrenoceptor beta 2
Previous Name	"adrenergic, beta-2-, receptor, surface\|adrenoceptor beta 2, surface"
Location	5q31-q32
Position	chr5:148825245-148828687, 1
External Links	HGNC: 286 Entrez Gene: 154 Ensembl: ENSG00000169252 UCSC: uc003lpr.2
No. of Association Results	1 (Positive: 0; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Hauser, M. A.,2017	PTSD diagnosis	rs2400707	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Hauser, M. A.,2017	PTSD diagnosis	Childhood trauma	rs2400707	Significant

Gene functional annotation

Gene related GO terms (count: 79)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	biological process	TAS[10734107]	2
GO:0042383	sarcolemma	cellular component	IEA	7
GO:0043627	response to estrogen	biological process	IEA	5
GO:0043197	dendritic spine	cellular component	IEA	9
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	biological process	IDA[15123695]	1
GO:0035255	ionotropic glutamate receptor binding	molecular function	IEA	2
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	25
GO:0005764	lysosome	cellular component	TAS[9507004]	4
GO:0097421	liver regeneration	biological process	IEA	1
GO:0007568	aging	biological process	IEA	11
GO:0071456	cellular response to hypoxia	biological process	IEA	4
GO:0002086	diaphragm contraction	biological process	IEA	1
GO:0008144	drug binding	molecular function	IEA	13
GO:0002024	diet induced thermogenesis	biological process	IEA	1
GO:0042060	wound healing	biological process	IEA	3
GO:0006898	receptor-mediated endocytosis	biological process	IDA[15123695]	9
GO:0030501	positive regulation of bone mineralization	biological process	IEA	1
GO:0005768	endosome	cellular component	TAS[10734107]	5
GO:0030279	negative regulation of ossification	biological process	IEA	2
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	TAS[2823249]	3
GO:0001965	G-protein alpha-subunit binding	molecular function	IEA	3
GO:0008179	adenylate cyclase binding	molecular function	IEA	2
GO:0016525	negative regulation of angiogenesis	biological process	IEA	4
GO:0043235	receptor complex	cellular component	IDA[15123695\|23382219]	3
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[1371121]	16
GO:0071548	response to dexamethasone	biological process	IEA	2
GO:0015459	potassium channel regulator activity	molecular function	IDA[12297500]	4
GO:0005634	nucleus	cellular component	IEA	81
GO:0050873	brown fat cell differentiation	biological process	IEA	3
GO:0008333	endosome to lysosome transport	biological process	TAS[9507004]	2
GO:0030424	axon	cellular component	IEA	16
GO:1904504	positive regulation of lipophagy	biological process	IDA[23708524]	1
GO:0005515	protein binding	molecular function	IPI[9560162\|9671706\|15123695\|17170700\|19424180\|19584355\|20353789\|20733053\|24405750]	169
GO:0005769	early endosome	cellular component	IEA	6
GO:0009409	response to cold	biological process	IEA	3
GO:0043065	positive regulation of apoptotic process	biological process	IEA	12
GO:0007267	cell-cell signaling	biological process	IBA	10
GO:0051379	epinephrine binding	molecular function	IBA	1
GO:0045986	negative regulation of smooth muscle contraction	biological process	IBA	1
GO:0050728	negative regulation of inflammatory response	biological process	IEA	5
GO:0035249	synaptic transmission, glutamatergic	biological process	IEA	2
GO:0007190	activation of adenylate cyclase activity	biological process	IDA[15123695]	6
GO:0005886	plasma membrane	cellular component	IDA[9235896]; TAS	99
GO:0035240	dopamine binding	molecular function	IEA	6
GO:0043268	positive regulation of potassium ion transport	biological process	IEA	1
GO:0032570	response to progesterone	biological process	IEA	2
GO:0040015	negative regulation of multicellular organism growth	biological process	IEA	1
GO:0016324	apical plasma membrane	cellular component	IEA	6
GO:0003059	positive regulation of the force of heart contraction by epinephrine	biological process	IEA	1
GO:0033574	response to testosterone	biological process	IEA	3
GO:1904925	positive regulation of mitophagy in response to mitochondrial depolarization	biological process	IGI[22020285]	1
GO:1901098	positive regulation of autophagosome maturation	biological process	IDA[23708524]	1
GO:0051924	regulation of calcium ion transport	biological process	IEA	1
GO:0090331	negative regulation of platelet aggregation	biological process	IEA	2
GO:0007565	female pregnancy	biological process	IEA	9
GO:0005887	integral component of plasma membrane	cellular component	IDA[12297500]	36
GO:0031398	positive regulation of protein ubiquitination	biological process	IMP[19372219]	2
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	biological process	IBA	2
GO:0043410	positive regulation of MAPK cascade	biological process	IDA[15123695]	3
GO:0031649	heat generation	biological process	IEA	1
GO:0071867	response to monoamine	biological process	IEA	1
GO:0044849	estrous cycle	biological process	IEA	3
GO:0010765	positive regulation of sodium ion transport	biological process	IEA	2
GO:0004941	beta2-adrenergic receptor activity	molecular function	IDA[15123695]	1
GO:0032781	positive regulation of ATPase activity	biological process	IEA	1
GO:0060079	excitatory postsynaptic potential	biological process	IEA	5
GO:0048633	positive regulation of skeletal muscle tissue growth	biological process	IEA	1
GO:0031713	B2 bradykinin receptor binding	molecular function	IEA	1
GO:0042803	protein homodimerization activity	molecular function	IDA[15123695]	18
GO:0045909	positive regulation of vasodilation	biological process	IEA	5
GO:0051930	regulation of sensory perception of pain	biological process	IEA	5
GO:0045453	bone resorption	biological process	IEA	2
GO:0051380	norepinephrine binding	molecular function	IDA[15123695]	1
GO:0008284	positive regulation of cell proliferation	biological process	IEA	14
GO:0032809	neuronal cell body membrane	cellular component	IEA	2
GO:0008306	associative learning	biological process	IEA	2
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	biological process	IBA	1
GO:0032403	protein complex binding	molecular function	IEA	8
GO:0035811	negative regulation of urine volume	biological process	IEA	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in PTSDgene
hsa04020	Calcium signaling pathway	11
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 171)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
ADRB2	IDH3G	No	--	--	23798571
ADRB2	DNAJB11	No	--	--	23798571
ADRB2	CAV3	Yes	--	--	21362625
ADRB2	EEF1D	No	--	--	23798571
ADRB2	NUP210	No	--	--	23798571
ADRB2	TUBB2A	No	--	--	23798571
ADRB2	GPRASP1	No	--	--	15452121
ADRB2	PDIA6	No	--	--	23798571
ADRB2	CANX	No	--	--	23798571
ADRB2	SEC61A1	No	--	--	23798571
ADRB2	SRC	No	--	--	17170700 , 17170700 , 17170700 , 17170700 , 17170700 , 17170700 , 11013230 , 17170700 , 17170700 , 17170700 , 11013230
ADRB2	KCNJ6	No	--	--	12297500
ADRB2	CNBP	No	--	--	17353931
ADRB2	MARCH2	No	--	colocalization	23166351 , 23166351
ADRB2	KPNB1	No	--	--	23798571
ADRB2	NSF	No	--	--	23798571
ADRB2	HSPA9	No	--	--	23798571
ADRB2	PC	No	--	--	23798571
ADRB2	TMX1	No	--	--	23798571
ADRB2	HADHB	No	--	--	23798571
ADRB2	GNB1	No	--	--	23798571 , 23798571 , 15782186
ADRB2	TMEM33	No	--	--	23798571
ADRB2	HNRNPH1	No	--	--	23798571
ADRB2	TARDBP	No	--	--	23798571
ADRB2	LMNB1	No	--	--	23798571
ADRB2	NDUFV1	No	--	--	23798571
ADRB2	UBB	No	--	--	23798571
ADRB2	IDH2	No	--	--	23798571
ADRB2	HSPA1A	No	--	--	23798571 , 23798571
ADRB2	KCNJ5	No	--	--	12297500
ADRB2	GNG2	No	--	--	15782186
ADRB2	FLNA	No	--	--	23798571
ADRB2	SLC25A6	No	--	--	23798571
ADRB2	SRPRB	No	--	--	23798571
ADRB2	NEDD4	No	--	--	23166351 , 20559325 , 18544533 , 18544533 , 18544533
ADRB2	HNRNPU	No	--	--	23798571
ADRB2	GNA11	No	--	--	7797501
ADRB2	PSMD2	No	--	--	23798571
ADRB2	AKAP5	No	--	--	10753752
ADRB2	PCBP2	No	--	--	23798571
ADRB2	ATP2B4	No	--	--	23798571
ADRB2	SV2A	No	--	--	23798571
ADRB2	MTHFD1	No	--	--	23798571
ADRB2	HSD17B4	No	--	--	23798571
ADRB2	EIF4A1	No	--	--	23798571
ADRB2	UBC	No	--	association	19424180 , 10 , 10 , 15331590 , 11588219 , 20559325 , 23166351 , 18544533 , 23798571 , 21330366 , 21330366 , 23236378 , 23798571
ADRB2	SLC1A5	No	--	--	23798571
ADRB2	AMFR	No	--	--	23798571 , 23798571 , 23798571
ADRB2	GNA15	No	--	--	7608160
ADRB2	ACTG1	No	--	--	23798571
ADRB2	HNRNPK	No	--	--	23798571
ADRB2	RAN	No	--	--	23798571
ADRB2	SYNJ2BP	No	--	--	23798571
ADRB2	C1QBP	No	--	--	23798571
ADRB2	SLC25A10	No	--	--	23798571
ADRB2	LRPPRC	No	--	--	23798571
ADRB2	GNAS	No	--	--	23798571 , 15782186
ADRB2	MAGI3	No	--	colocalization	20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789 , 20353789
ADRB2	PPP3CA	No	biochemical	colocalization	9880537
ADRB2	CNNM3	No	--	--	23798571
ADRB2	UCHL1	No	--	--	19477270
ADRB2	PON2	No	--	--	23798571
ADRB2	CUL2	No	--	--	19584355
ADRB2	UQCRC2	No	--	--	23798571
ADRB2	RPS5	No	--	--	23798571
ADRB2	HSPA5	No	--	--	23798571
ADRB2	USP20	No	--	--	23166351
ADRB2	HTR4	No	--	--	15896782 , 15896782 , 15896782 , 15896782
ADRB2	ARR3	No	--	--	11877451
ADRB2	LONP1	No	--	--	23798571
ADRB2	ATP5O	No	--	--	23798571
ADRB2	LAMP2	No	--	colocalization	10 , 10 , 19424180
ADRB2	ATP2A2	No	--	--	23798571
ADRB2	PDHA1	No	--	--	23798571
ADRB2	GNG12	No	--	--	23798571
ADRB2	SLC9A3R2	No	--	--	23798571 , 9671706 , 9671706
ADRB2	GNB2L1	No	--	--	23798571
ADRB2	NUP93	No	--	--	23798571
ADRB2	TUFM	No	--	--	23798571
ADRB2	ATP5A1	No	--	--	23798571
ADRB2	SHMT2	No	--	--	23798571
ADRB2	KRT10	No	--	--	23798571
ADRB2	PHB2	No	--	--	23798571
ADRB2	ATP1B3	No	--	--	23798571
ADRB2	CSK	No	--	--	11278940
ADRB2	SLIRP	No	--	--	23798571
ADRB2	KCNJ9	No	--	--	12297500
ADRB2	PRKDC	No	--	--	23798571
ADRB2	MYLK2	No	--	--	23798571
ADRB2	SLC25A13	No	--	--	23798571
ADRB2	EEF2	No	--	--	23798571
ADRB2	PHB	No	--	--	23798571
ADRB2	USP33	No	--	colocalization, association	10 , 23166351 , 10 , 19424180 , 19424180 , 10 , 10
ADRB2	KRT2	No	--	--	23798571
ADRB2	ARRDC3	No	--	colocalization	23236378 , 20559325 , 23236378 , 23208550 , 23208550 , 23236378
ADRB2	PRKCD	No	--	--	1848190
ADRB2	MTHFD1L	No	--	--	23798571
ADRB2	SLC25A11	No	--	--	23798571
ADRB2	PTGER1	No	--	--	16670773
ADRB2	FKBP8	No	--	--	23798571
ADRB2	MRPL12	No	--	--	23798571
ADRB2	HSPD1	No	--	--	23798571
ADRB2	IDH3A	No	--	--	23798571
ADRB2	SLC25A3	No	--	--	23798571
ADRB2	AKAP12	No	biochemical	colocalization	11309381 , 11309381 , 9880537 , 9880537
ADRB2	UFD1L	No	--	--	23798571
ADRB2	HLA-C	No	--	--	23798571
ADRB2	MCCC2	No	--	--	23798571
ADRB2	ATP5C1	No	--	--	23798571
ADRB2	TMUB1	No	--	--	23798571
ADRB2	IMMT	No	--	--	23798571
ADRB2	HSD17B12	No	--	--	23798571
ADRB2	NOS1	Yes	--	--	12184796
ADRB2	VDAC2	No	--	--	23798571
ADRB2	TRAF1	No	--	--	23798571
ADRB2	EGLN3	No	--	--	19584355 , 19584355 , 19584355
ADRB2	SERPINH1	No	--	--	23798571
ADRB2	HNRNPF	No	--	--	23798571
ADRB2	KCNJ3	No	--	--	12297500
ADRB2	VHL	No	--	--	19584355
ADRB2	ETFB	No	--	--	23798571
ADRB2	DAD1	No	--	--	23798571
ADRB2	RNF5	No	--	--	23798571 , 23798571
ADRB2	JKAMP	No	--	--	23798571 , 23798571
ADRB2	HSP90B1	No	--	--	23798571
ADRB2	ITCH	No	--	--	23236378 , 18544533
ADRB2	EIF2B1	No	--	colocalization	9235896 , 9235896 , 9235896 , 9235896
ADRB2	TIMM50	No	--	--	23798571
ADRB2	PDHB	No	--	--	23798571
ADRB2	MAPK14	No	--	--	23798571
ADRB2	SSR4	No	--	--	23798571
ADRB2	STOM	No	--	--	23798571
ADRB2	ECM29	No	--	--	23798571
ADRB2	GNAI3	No	--	--	23798571
ADRB2	TCEB1	No	--	--	19584355
ADRB2	ARRB1	Yes	--	--	16407241 , 18544533
ADRB2	NDUFA5	No	--	--	23798571
ADRB2	GCDH	No	--	--	23798571
ADRB2	DSG2	No	--	--	23798571
ADRB2	ILVBL	No	--	--	23798571
ADRB2	HSDL2	No	--	--	23798571
ADRB2	GRK5	No	--	--	8662852
ADRB2	ADRB3	No	--	--	15123695
ADRB2	ADRBK1	No	--	--	14654844 , 11309381
ADRB2	DLAT	No	--	--	23798571
ADRB2	GNB4	No	--	--	23798571 , 23798571
ADRB2	EEF1B2	No	--	--	23798571
ADRB2	TM9SF3	No	--	--	23798571
ADRB2	GFM1	No	--	--	23798571
ADRB2	DKFZp686J1895	No	--	--	17353931
ADRB2	CALM1	No	--	--	23798571 , 23798571 , 23798571
ADRB2	TTN	No	--	--	23798571
ADRB2	GNB2	No	--	--	23798571 , 23798571
ADRB2	RAB18	No	--	--	23798571
ADRB2	NPLOC4	No	--	--	23798571
ADRB2	VCP	No	--	--	23798571
ADRB2	ALDH18A1	No	--	--	23798571
ADRB2	SLC39A14	No	--	--	23798571
ADRB2	RANBP2	No	--	--	23798571
ADRB2	GRK6	No	--	--	9819198 , 9819198
ADRB2	ARRB2	No	--	colocalization	17666399 , 23208550 , 23208550 , 18544533 , 17666399 , 18544533 , 18544533
ADRB2	C19orf6	No	--	--	23798571
ADRB2	PCBP1	No	--	--	23798571
ADRB2	FAM162A	No	--	--	23798571
ADRB2	HNRNPA2B1	No	--	--	23798571
ADRB2	EEF1A1	No	--	--	23798571
ADRB2	KRT5	No	--	--	23798571
ADRB2	MDM2	No	--	--	18544533 , 11588219
ADRB2	OPRD1	No	--	--	11278447 , 11278447 , 11278447
ADRB2	EEF1G	No	--	--	23798571
ADRB2	GRB2	No	coimmunoprecipitation	association	9830057 , 9830057 , 9830057 , 9830057 , 9830057 , 9830057