
Gene Report
Approved Symbol | BDNF |
---|---|
Approved Name | brain-derived neurotrophic factor |
Name Alias | neurotrophin |
Location | 11p14.1 |
Position | chr11:27654893-27722058, -1 |
External Links |
HGNC: 1033 Entrez Gene: 627 Ensembl: ENSG00000176697 UCSC: uc009yje.3 |
No. of Association Results | 19 (Positive: 4; Negative: 15; trend: 0) |
Annotation Type | Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target |
Reference | Phenotype | Marker | Gene's Category |
---|---|---|---|
Bruenig, D.,2016 | CAPS score | rs6265 | Non-significant |
Li, R. H.,2016 | Changes in PTSD severity between 6 and 12 months | rs6265 | Non-significant |
Li, R. H.,2016 | Changes in PTSD severity between 6 and 18 months | rs6265 | Non-significant |
Li, R. H.,2016 | Changes in PTSD severity between 12 and 18 months | rs6265 | Significant |
van den Heuvel, L.,2016 | PTSD diagnosis | rs6265 | Non-significant |
van den Heuvel, L.,2016 | CAPS score | rs6265 | Non-significant |
Zhang, H.,2006 | PTSD | BDNF_5'region_G712A ; BDNF_exon_C270T ; rs6265 | Non-significant |
Zhang, H.,2006 | Posttraumatic Stress Disorder | G-712A-C270T-Val66Met, G-C-A,G-C-G,G-T-G,A-C-G,A-T-A,A-T-G | Non-significant |
Li, R. H.,2016 | PCL-C Scores of the Subjects with Different Genotypes of BDNF Val66Met at 6 or 12 or 18 Months After the Earthquake | rs6265 | Significant |
Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | rs6265 | Non-significant |
Dunn, E. C.,2014 | Post-traumatic stress symptoms (PTS) | rs6265 | Non-significant |
Li, R. H.,2016 | Prevalence of PTSD in the Subjects with Different BDNF Val66Met Genotypes at 6 or 12 or 18 Months After the Earthquake | rs6265 | Significant |
Pivac, N.,2012 | Psychotic symptoms in PTSD | rs6265 | Significant |
Valente, N. L.,2011 | PTSD | rs6265 | Non-significant |
Wang, T.,2015 | PTSD | rs6265 | Non-significant |
Lee, Heon-Jeong,2006 | PTSD | rs6265 | Non-significant |
Solovieff, N.,2014 | PTSD diagnosis | rs2140887 | Non-significant |
Solovieff, N.,2014 | PTSD severity | rs1464896 | Non-significant |
La Greca, A. M.,2013 | PTSD symptoms | rs6265 | Non-significant |
Reference | Phenotype | Environment | Marker | Gene's Category |
---|---|---|---|---|
Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | Hurricane exposure | rs6265 | Non-significant |
ID | Name | No. of Genes in PTSDgene |
---|---|---|
hsa05040 | Huntington's disease | 4 |
hsa04010 | MAPK signaling pathway | 13 |
Gene | Interactor | Interactor in PTSDgene? | Experiment Method | Interaction Type | PMID |
---|---|---|---|---|---|
BDNF | EIF2C3 | No | -- | -- | 21988832 , 21988832 |
BDNF | NTRK2 | No | -- | -- | 9312147 , 9312147 , 9312147 , 11855816 |
BDNF | MBTPS1 | No | -- | -- | 9990022 |
BDNF | INPP5K | No | -- | -- | 21988832 , 21988832 |
BDNF | F11R | No | -- | -- | 21988832 , 21988832 |
BDNF | ELAVL1 | No | -- | -- | 19322201 |
BDNF | NOS3 | No | -- | -- | 10493752 |
BDNF | SORT1 | No | -- | -- | 15987945 , 19122660 |
BDNF | CADPS2 | No | -- | -- | 14715936 |
Copyright: Key Lab of Mental Health, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: April 1, 2018