Gene Report

Basic Info

Approved Symbol	BDNF
Approved Name	brain-derived neurotrophic factor
Name Alias	neurotrophin
Location	11p14.1
Position	chr11:27654893-27722058, -1
External Links	HGNC: 1033 Entrez Gene: 627 Ensembl: ENSG00000176697 UCSC: uc009yje.3
No. of Association Results	19 (Positive: 4; Negative: 15; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 19)

Reference	Phenotype	Marker	Gene's Category
Bruenig, D.,2016	CAPS score	rs6265	Non-significant
Li, R. H.,2016	Changes in PTSD severity between 6 and 12 months	rs6265	Non-significant
Li, R. H.,2016	Changes in PTSD severity between 6 and 18 months	rs6265	Non-significant
Li, R. H.,2016	Changes in PTSD severity between 12 and 18 months	rs6265	Significant
van den Heuvel, L.,2016	PTSD diagnosis	rs6265	Non-significant
van den Heuvel, L.,2016	CAPS score	rs6265	Non-significant
Zhang, H.,2006	PTSD	BDNF_5'region_G712A ; BDNF_exon_C270T ; rs6265	Non-significant
Zhang, H.,2006	Posttraumatic Stress Disorder	G-712A-C270T-Val66Met, G-C-A,G-C-G,G-T-G,A-C-G,A-T-A,A-T-G	Non-significant
Li, R. H.,2016	PCL-C Scores of the Subjects with Different Genotypes of BDNF Val66Met at 6 or 12 or 18 Months After the Earthquake	rs6265	Significant
Dunn, E. C.,2014	Post Traumatic Growth (PTG)	rs6265	Non-significant
Dunn, E. C.,2014	Post-traumatic stress symptoms (PTS)	rs6265	Non-significant
Li, R. H.,2016	Prevalence of PTSD in the Subjects with Different BDNF Val66Met Genotypes at 6 or 12 or 18 Months After the Earthquake	rs6265	Significant
Pivac, N.,2012	Psychotic symptoms in PTSD	rs6265	Significant
Valente, N. L.,2011	PTSD	rs6265	Non-significant
Wang, T.,2015	PTSD	rs6265	Non-significant
Lee, Heon-Jeong,2006	PTSD	rs6265	Non-significant
Solovieff, N.,2014	PTSD diagnosis	rs2140887	Non-significant
Solovieff, N.,2014	PTSD severity	rs1464896	Non-significant
La Greca, A. M.,2013	PTSD symptoms	rs6265	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Dunn, E. C.,2014	Post Traumatic Growth (PTG)	Hurricane exposure	rs6265	Non-significant

Gene functional annotation

Gene related GO terms (count: 39)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0061193	taste bud development	biological process	IEA	1
GO:0007416	synapse assembly	biological process	IDA[19036963]	4
GO:0051965	positive regulation of synapse assembly	biological process	IDA[19036963]	6
GO:0007631	feeding behavior	biological process	IEA	3
GO:0005737	cytoplasm	cellular component	ISS	109
GO:0097484	dendrite extension	biological process	IEA	1
GO:0042493	response to drug	biological process	IEA	25
GO:0014047	glutamate secretion	biological process	IEA	1
GO:0043524	negative regulation of neuron apoptotic process	biological process	IBA	4
GO:0016358	dendrite development	biological process	IEA	3
GO:0031550	positive regulation of brain-derived neurotrophic factor receptor signaling pathway	biological process	TAS[19036963]	1
GO:0021675	nerve development	biological process	IEA	1
GO:0001657	ureteric bud development	biological process	IEA	2
GO:0008083	growth factor activity	molecular function	IEA	1
GO:0007411	axon guidance	biological process	TAS[19036963]	16
GO:0060080	inhibitory postsynaptic potential	biological process	IEA	3
GO:0048471	perinuclear region of cytoplasm	cellular component	ISS	14
GO:0007406	negative regulation of neuroblast proliferation	biological process	IEA	2
GO:0042490	mechanoreceptor differentiation	biological process	IEA	1
GO:0032229	negative regulation of synaptic transmission, GABAergic	biological process	IEA	1
GO:0046668	regulation of retinal cell programmed cell death	biological process	IEA	1
GO:0048668	collateral sprouting	biological process	IDA[19036963]	1
GO:0098794	postsynapse	cellular component	IEA	1
GO:0007214	gamma-aminobutyric acid signaling pathway	biological process	IEA	4
GO:0005169	neurotrophin TRKB receptor binding	molecular function	IBA	1
GO:0007399	nervous system development	biological process	TAS[2236018]	7
GO:0019222	regulation of metabolic process	biological process	IEA	1
GO:0007412	axon target recognition	biological process	IEA	1
GO:0007611	learning or memory	biological process	IEA	6
GO:0007267	cell-cell signaling	biological process	IBA	10
GO:0005576	extracellular region	cellular component	IEA	31
GO:0008038	neuron recognition	biological process	IEA	2
GO:0048672	positive regulation of collateral sprouting	biological process	IDA[19036963]	1
GO:0001662	behavioral fear response	biological process	IEA	7
GO:0016023	cytoplasmic, membrane-bounded vesicle	cellular component	IBA	6
GO:0048167	regulation of synaptic plasticity	biological process	IEA	1
GO:0048839	inner ear development	biological process	IEA	2
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway	biological process	TAS[19036963]	1
GO:0048675	axon extension	biological process	IEA	3

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in PTSDgene
hsa05040	Huntington's disease	4
hsa04010	MAPK signaling pathway	13

Gene related interactors from protein-protein interactions data in PINA v2 (count: 9)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
BDNF	F11R	No	--	--	21988832 , 21988832
BDNF	SORT1	No	--	--	15987945 , 19122660
BDNF	MBTPS1	No	--	--	9990022
BDNF	NOS3	No	--	--	10493752
BDNF	INPP5K	No	--	--	21988832 , 21988832
BDNF	NTRK2	No	--	--	9312147 , 9312147 , 9312147 , 11855816
BDNF	EIF2C3	No	--	--	21988832 , 21988832
BDNF	CADPS2	No	--	--	14715936
BDNF	ELAVL1	No	--	--	19322201