Gene Report

Basic Info

Approved Symbol	SLC18A2
Previous Symbol	VMAT2
Symbol Alias	"SVMT\|SVAT"
Approved Name	solute carrier family 18 (vesicular monoamine transporter), member 2
Location	10q25
Position	chr10:117241093-117279430, 1
External Links	HGNC: 10935 Entrez Gene: 6571 Ensembl: ENSG00000165646 UCSC: uc001ldd.2
No. of Association Results	3 (Positive: 2; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 3)

Reference	Phenotype	Marker	Gene's Category
Solovieff, N.,2014	PTSD diagnosis	rs10082463 - rs2015586 - rs363223 - rs363256 - rs363230 - rs363272 - rs2244249 - rs363276 - rs363279, CGGCGGAAG ; rs363276	Significant
Nievergelt, C. M.,2015	PTSD	rs363238	Significant
Solovieff, N.,2014	PTSD severity	rs363276	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs363238	Non-significant

Gene functional annotation

Gene related GO terms (count: 40)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007568	aging	biological process	IEA	11
GO:0007626	locomotory behavior	biological process	IEA	9
GO:0008144	drug binding	molecular function	IEA	13
GO:0006837	serotonin transport	biological process	IEA	2
GO:0001975	response to amphetamine	biological process	IEA	9
GO:1903427	negative regulation of reactive oxygen species biosynthetic process	biological process	NAS[24252804]	1
GO:0005275	amine transmembrane transporter activity	molecular function	IEA	1
GO:0055085	transmembrane transport	biological process	TAS	14
GO:0009635	response to herbicide	biological process	IEA	2
GO:0042594	response to starvation	biological process	IEA	2
GO:0042220	response to cocaine	biological process	IEA	7
GO:0005887	integral component of plasma membrane	cellular component	TAS[8095030]	36
GO:0042593	glucose homeostasis	biological process	IEA	7
GO:0008504	monoamine transmembrane transporter activity	molecular function	TAS[8095030]	4
GO:0008021	synaptic vesicle	cellular component	TAS[21563316]	6
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane	cellular component	TAS	1
GO:0051412	response to corticosterone	biological process	IEA	3
GO:0009791	post-embryonic development	biological process	IEA	3
GO:0098700	neurotransmitter loading into synaptic vesicle	biological process	TAS[21563316]	1
GO:0031045	dense core granule	cellular component	IEA	2
GO:0019899	enzyme binding	molecular function	IEA	13
GO:0015844	monoamine transport	biological process	TAS[8095030]	4
GO:0010043	response to zinc ion	biological process	IEA	2
GO:0043025	neuronal cell body	cellular component	IEA	18
GO:0043195	terminal bouton	cellular component	IEA	7
GO:0030672	synaptic vesicle membrane	cellular component	IEA	3
GO:0007269	neurotransmitter secretion	biological process	TAS	4
GO:0015837	amine transport	biological process	IEA	1
GO:0030073	insulin secretion	biological process	IEA	2
GO:0015222	serotonin transmembrane transporter activity	molecular function	IEA	2
GO:0015872	dopamine transport	biological process	TAS[21563316]	2
GO:0035690	cellular response to drug	biological process	IEA	6
GO:0051589	negative regulation of neurotransmitter transport	biological process	IEA	1
GO:0007268	synaptic transmission	biological process	TAS[15217342]	32
GO:0031072	heat shock protein binding	molecular function	IEA	2
GO:0071242	cellular response to ammonium ion	biological process	IEA	1
GO:0016020	membrane	cellular component	TAS[8095030]	42
GO:0042137	sequestering of neurotransmitter	biological process	NAS[24252804]	1
GO:0032456	endocytic recycling	biological process	IEA	1

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 1)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
SLC18A2	PARK7	No	--	colocalization	22554508 , 22554508 , 22554508