Study Report

Study Information

Basic Info

Reference	Watkins, L. E.,2016 PMID: 27078785
Citation	Watkins, L. E., et al. (2016). "FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study." Psychoneuroendocrinology 69: 98-105.
Phenotype	Lifetime PTSD symptom severity, Re-experiencing symptoms, Avoidance symptoms(DSM-IV), Emotional numbing symptoms, Hyperaousal symptoms, Intrusion symptoms, Avoidance symptoms(DSM-5), Negative alterations in cognitions and mood symptoms, Alterations in arousal and reactivity symptoms
Trauma	Combat
Study Design	Cross-sectional study
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	1585 samples
SNP/Marker Size	4 SNPs
Predominant Ethnicity	Caucasian
Population	American
Gender	Main sample: 1442 males, 143 females. Replication sample: 521 males, 56 females.
Age	Main sample: mean age=62.9 years,SD=14.3. Replication sample: mean age=62.2 years,SD=15.6.

Detail Info

Sample Diagnosis	DSM-IV,DSM-5
Related Diagnostic Tools	The PTSD Checklist DSM-IV version (PCL-IV), The PTSD Checklist DSM-5 version (PCL-5), The Mini-International Neuropsychiatric Interview (MINI)
Sample Status	Main sample: 16.4% with lifetime MDD, 46.5% with lifetime alcohol use disorder, 13.5% with lifetime drug use disorder. Replication sample: 10.8% with lifetime MDD, 41.2% with lifetime alcohol use disorder, 12.5% with lifetime drug use disorder.
Controls Exposed	NA
Replication Size	577 samples
Result Summary	Results revealed that the four FKBP5 SNPs were associated with PTSD symptom severity in both samples. Further, SNP rs9470080 in the main sample, and all four SNPs in the replication sample interacted with childhood abuse to predict PTSD severity. In both samples, all four FKBP5 SNPs predicted hyperarousal/alterations in arousal and reactivity. Results of this study suggest that FKBP5 polymorphisms, directly and interactively with childhood abuse, predict severity of lifetime PTSD symptoms, most notably hyperarousal symptoms, in two nationally representative samples of EA veterans. They further indicate that FKBP5 polymorphisms and childhood abuse may contribute to vulnerability for PTSD symptoms and may be most strongly associated with trauma-related hyperarousal symptoms that comprise this phenotype.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 36)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs9296158	Lifetime PTSD symptoms	FKBP5	Main sample: F=4.42, P-value=0.012. Replication sample: F=6.79, P-value=0.001.	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs3800373	Lifetime PTSD symptoms	FKBP5	Main sample: F=7.30, P-value=0.001. Replication sample: F=4.76, P-value=0.009.	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs9470080	Lifetime PTSD symptoms	FKBP5	Main smaple: F=6.33, P-value=0.002. Replication sample: F=7.36, P-value=0.001.	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs1360780	Lifetime PTSD symptoms	FKBP5	Main sample: F=4.67, P-value=0.010. Replication sample: F=6.79, P-value=0.001.	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs1360780	Avoidance symptoms (DSM-IV)	FKBP5	F=3.18, P-value=0.042	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs9470080	Avoidance symptoms (DSM-IV)	FKBP5	F=6.02, P-value=0.003	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs3800373	Avoidance symptoms (DSM-IV)	FKBP5	F=5.59, P-value=0.004	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs9296158	Avoidance symptoms (DSM-IV)	FKBP5	F=3.53, P-value=0.030	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs1360780	Re-experiencing symptoms	FKBP5	F=3.30, P-value=0.037	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs9470080	Re-experiencing symptoms	FKBP5	F=5.49, P-value=0.004	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs3800373	Re-experiencing symptoms	FKBP5	F=5.69, P-value=0.003	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs9296158	Re-experiencing symptoms	FKBP5	F=4.08, P-value=0.017	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs1360780	Hyperarousal symptoms	FKBP5	F=6.99, P-value=0.001	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs9470080	Hyperarousal symptoms	FKBP5	F=6.34, P-value=0.002	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs3800373	Hyperarousal symptoms	FKBP5	F=8.03, P-value<0.001	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs9296158	Hyperarousal symptoms	FKBP5	F=6.74, P-value=0.001	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs1360780	Emotional numbing	FKBP5	F=1.06, P-value=0.35	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs9470080	Emotional numbing	FKBP5	F=2.13, P-value=0.12	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs3800373	Emotional numbing	FKBP5	F=2.06, P-value=0.13	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs9296158	Emotional numbing	FKBP5	F=0.57, P-value=0.56	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs9470080	Avoidance symptoms (DSM-5)	FKBP5	F=3.00, P-value=0.051	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs1360780	Avoidance symptoms (DSM-5)	FKBP5	F=0.70, P-value=0.49	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs9296158	Avoidance symptoms (DSM-5)	FKBP5	F=0.75, P-value=0.47	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs3800373	Avoidance symptoms (DSM-5)	FKBP5	F=2.64, P-value=0.073	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs9470080	Intrusion symptoms	FKBP5	F=4.74, P-value=0.009	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs1360780	Intrusion symptoms	FKBP5	F=5.83, P-value=0.003	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs9296158	Intrusion symptoms	FKBP5	F=5.83, P-value=0.003	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs3800373	Intrusion symptoms	FKBP5	F=7.42, P-value=0.001	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs9470080	Alterations in arousal and reactivity symptoms	FKBP5	F=14.01, P-value<0.001	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs1360780	Alterations in arousal and reactivity symptoms	FKBP5	F=17.12, P-value<0.001	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs9296158	Alterations in arousal and reactivity symptoms	FKBP5	F=17.10, P-value<0.001	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs3800373	Alterations in arousal and reactivity symptoms	FKBP5	F=10.96, P-value<0.001	Main effect of this SNP is significant. Main effect of this SNP is significant.	Significant
rs9470080	Negative alterations in cognitions and mood symptoms	FKBP5	F=4.46, P-value=0.012	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs1360780	Negative alterations in cognitions and mood symptoms	FKBP5	F=5.55, P-value=0.004	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs9296158	Negative alterations in cognitions and mood symptoms	FKBP5	F=5.43, P-value=0.005	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
rs3800373	Negative alterations in cognitions and mood symptoms	FKBP5	F=2.48, P-value=0.085	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant

Gene * Environment result reported by this study (count: 36)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs3800373	Lifetime PTSD symptoms	FKBP5	Childhood abuse	Main sample: F=3.47, P-value=0.031. Replication sample: F=5.51, P-value=0.004.	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant
rs9296158	Lifetime PTSD symptoms	FKBP5	Childhood abuse	Main sample: F=2.50, P-value=0.041. Replication sample: F=5.79, P-value=0.003.	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant
rs1360780	Lifetime PTSD symptoms	FKBP5	Childhood abuse	Main sample: F=2.45, P-value=0.044. Replication sample: F=5.79, P-value=0.003.	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant
rs9470080	Lifetime PTSD symptoms	FKBP5	Childhood abuse	Main smaple: F=3.65, P-value=0.006. Replication sample: F=6.09, P-value=0.002.	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant
rs9296158	Re-experiencing symptoms	FKBP5	Childhood abuse	F=3.35, P-value=0.036	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs3800373	Re-experiencing symptoms	FKBP5	Childhood abuse	F=4.03, P-value=0.018	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9470080	Re-experiencing symptoms	FKBP5	Childhood abuse	F=1.23, P-value=0.29	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs1360780	Re-experiencing symptoms	FKBP5	Childhood abuse	F=1.87, P-value=0.16	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9296158	Avoidance symptoms (DSM-IV)	FKBP5	Childhood abuse	F=0.57, P-value=0.57	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs3800373	Avoidance symptoms (DSM-IV)	FKBP5	Childhood abuse	F=1.29, P-value=0.27	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9470080	Avoidance symptoms (DSM-IV)	FKBP5	Childhood abuse	F=0.62, P-value=0.54	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs1360780	Avoidance symptoms (DSM-IV)	FKBP5	Childhood abuse	F=0.77, P-value=0.46	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9296158	Emotional numbing	FKBP5	Childhood abuse	F=0.31, P-value=0.73	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs3800373	Emotional numbing	FKBP5	Childhood abuse	F=0.38, P-value=0.68	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9470080	Emotional numbing	FKBP5	Childhood abuse	F=0.29, P-value=0.75	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs1360780	Emotional numbing	FKBP5	Childhood abuse	F=0.53, P-value=0.59	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9296158	Hyperarousal symptoms	FKBP5	Childhood abuse	F=3.93, P-value=0.020	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs3800373	Hyperarousal symptoms	FKBP5	Childhood abuse	F=4.55, P-value=0.011	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9470080	Hyperarousal symptoms	FKBP5	Childhood abuse	F=5.14, P-value=0.006	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs1360780	Hyperarousal symptoms	FKBP5	Childhood abuse	F=3.53, P-value=0.030	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs1360780	Intrusion symptoms	FKBP5	Childhood abuse	F=4.42, P-value=0.013	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9470080	Intrusion symptoms	FKBP5	Childhood abuse	F=4.74, P-value=0.009	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs3800373	Intrusion symptoms	FKBP5	Childhood abuse	F=5.93, P-value=0.003	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant
rs9296158	Intrusion symptoms	FKBP5	Childhood abuse	F=4.40, P-value=0.013	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs1360780	Avoidance symptoms (DSM-5)	FKBP5	Childhood abuse	F=4.04, P-value=0.018	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9470080	Avoidance symptoms (DSM-5)	FKBP5	Childhood abuse	F=3.00, P-value=0.051	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs3800373	Avoidance symptoms (DSM-5)	FKBP5	Childhood abuse	F=7.71, P-value=0.001	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant
rs9296158	Avoidance symptoms (DSM-5)	FKBP5	Childhood abuse	F=3.84, P-value=0.022	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs1360780	Negative alterations in cognitions and mood symptoms	FKBP5	Childhood abuse	F=3.49, P-value=0.035	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9470080	Negative alterations in cognitions and mood symptoms	FKBP5	Childhood abuse	F=4.46, P-value=0.012	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs3800373	Negative alterations in cognitions and mood symptoms	FKBP5	Childhood abuse	F=1.33, P-value=0.26	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9296158	Negative alterations in cognitions and mood symptoms	FKBP5	Childhood abuse	F=3.48, P-value=0.032	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs1360780	Alterations in arousal and reactivity symptoms	FKBP5	Childhood abuse	F=12.83, P-value<0.001	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant
rs9470080	Alterations in arousal and reactivity symptoms	FKBP5	Childhood abuse	F=14.01, P-value<0.001	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant
rs3800373	Alterations in arousal and reactivity symptoms	FKBP5	Childhood abuse	F=5.46, P-value=0.005	The interaction effect of the SNP and childhood abuse is not...... The interaction effect of the SNP and childhood abuse is not significant. More...	Non-significant
rs9296158	Alterations in arousal and reactivity symptoms	FKBP5	Childhood abuse	F=12.88, P-value<0.001	The interaction effect of the SNP and childhood abuse is sig...... The interaction effect of the SNP and childhood abuse is significant. More...	Significant