PTSDgene database

SNP Report

Basic Info
Name rs2400707 dbSNP Ensembl
Location 5:148825489 - 148825489(+)
Variant Seq G
Ancestral Allele G
Ref Seq A
Minor Allele Frequence 0.346446
Annotation 5_prime_UTR_variant
Variant Effect 5_prime_UTR_variant(ENST00000305988)
SIFT Annotation deleterious
SIFT Variant Effect deleterious(ENST00000305988)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000305988)
rSNP? Yes Link in rVarBase
Related Regulatory Elements TF binding region;Chromatin interactive region
Chromatin State Enhancers;Flanking Active TSS;Active TSS;Weak transcription;Bivalent/Poised TSS
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Hauser, M. A.,2017 PTSD diagnosis P-value>0.05 P-value>0.05 No main effects of rs2400707 on PTSD diagnosis were observed...... No main effects of rs2400707 on PTSD diagnosis were observed in either the NHB or NHW subset of our data set. More... Non-significant
G*E study related association result (count: 5)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Hauser, M. A.,2017 PTSD diagnosis Childhood trauma Among the NHB cohort: P-value=0.038. Among the NHW cohort: P...... Among the NHB cohort: P-value=0.038. Among the NHW cohort: P-value=0.892. More... The interaction with rs2400707 and childhood trauma was obse...... The interaction with rs2400707 and childhood trauma was observed among NMB participants but not observed among the NHW study participants. More... Significant
Liberzon, I.,2014 Avoidance symptoms Adverse childhood event (ACE) Subscales of PTSD symptoms, avoidance symptoms: mean B=0.82,...... Subscales of PTSD symptoms, avoidance symptoms: mean B=0.82, SD=0.24, t=3.43, P-value=.0006. More... All 3 subscales of PTSD symptoms showed rs2400707 x ACE inte...... All 3 subscales of PTSD symptoms showed rs2400707 x ACE interaction, including intrusive and hyperarousal; however, the subscale for avoidance symptoms had the most robust interaction. More... Significant
Liberzon, I.,2014 Hyperarousal symptoms Adverse childhood event (ACE) Subscales of PTSD symptoms, hyperarousal: mean B=0.61, SD=0....... Subscales of PTSD symptoms, hyperarousal: mean B=0.61, SD=0.20, t=3.07, P-value=.002. More... All 3 subscales of PTSD symptoms showed rs2400707 x ACE inte...... All 3 subscales of PTSD symptoms showed rs2400707 x ACE interaction, including intrusive and hyperarousal; however, the subscale for avoidance symptoms had the most robust interaction. More... Significant
Liberzon, I.,2014 Intrusive symptoms Adverse childhood event (ACE) Subscales of PTSD symptoms, intrusive: mean B=0.47, SD=0.17,...... Subscales of PTSD symptoms, intrusive: mean B=0.47, SD=0.17, t=2.79, P-value=.005. More... All 3 subscales of PTSD symptoms showed rs2400707 x ACE inte...... All 3 subscales of PTSD symptoms showed rs2400707 x ACE interaction, including intrusive and hyperarousal; however, the subscale for avoidance symptoms had the most robust interaction. More... Significant
Liberzon, I.,2014 PTSD symptoms Adverse childhood event (ACE) Linear regression model controlling for adult trauma exposur...... Linear regression model controlling for adult trauma exposure, the SNP x ACE interaction: mean unstandardized estimate B= 3.07, SD=0.69, beta=0.243, t=4.48, P-value=1.02-5e. Stratification of the sample by ACEs in persons with 2 or more reported categories of ACEs:n=93, mean B =?6.44, SD=2.08, t=?3.10, P-value=.003. Secondary analysis of binary logistic regression of PTSD caseness: rs2400707 x ACE interaction: OR=0.54, P-value=5.16-4e. Addition of PCs of rs2400707: P-value=1.11-5e. The rs2407007 x ACE interaction in the association with PTSD symptoms in the Grady Trauma Project: mean B=1.80, SD=0.54, t=3.328, P-value=.0009; when using robust standard errors: mean B=1.81, SD=0.60, t=3.02, P-value=.0026 after controlling for sex and adult trauma exposure: mean B=1.58, SD=0.50, t=3.15, P-value=.0017 and after controlling for the 10 PCs: mean B=1.55, SD=0.51, t=3.06, P-value=.0022. In persons with 2 or more reported ACEs: n=197, mean B=?5.34, SD=1.35, t=3.95, P-value=.00011). More... Significant associations were detected for the SNP x ACE int...... Significant associations were detected for the SNP x ACE interaction term in rs2400707. Permutation analysis of the SNP x ACE interaction term further confirmed a significant association with rs2400707 (P-value < .05 corrected for multiple comparisons). As shown in Figure 1A, rs2400707 AA homozygotes demonstrated lower levels of PTSD symptoms in the presence of 2 or more categories of reported childhood adversity in the discovery cohort. Stratification of the sample by ACEs showed an effect of rs2400707 only in persons with 2 or more reported categories of ACEs. Although our primary focus was on continuous measures of PTSD severity, a secondary analysis of binary logistic regression of PTSD caseness confirmed an rs2400707 x ACE interaction, indicating that the A allele is protective in terms of adult PTSD symptoms on categorical PTSD diagnosis. Addition of PCs did not alter the significant association of rs2400707. The rs2407007 x ACE interaction in the association with PTSD symptoms in the Grady Trauma Project remained significant when using robust standard errors after controlling for sex and adult trauma exposure and after controlling for the 10 PCs. Again, an effect of rs2400707 was found only in persons with 2 or more reported ACEs. We tested the same model (linear regression of SNP, ACEs, adult trauma, and SNP x ACE and SNP x adult trauma interaction terms) in the combined data set (adjusting symptom severity measures to the same scale) of both the discovery and replication cohorts. We found that the rs2400707 x ACE interaction term had a mean. More... Significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
ADRB2 adrenoceptor beta 2 5q31-q32 1(0/1/0)

SNPs in LD with rs2400707 (count: 24)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 24)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1-IT1 Yes Adipose Subcutaneous cis GTEx