PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	David, A. C.,2012 PMID: 25379217
Citation	David, A. C., et al. (2012). "Symptom persistence and memory performance in posttraumatic stress disorder: a gene x environment pilot stud." Behav Sci (Basel) 2(2): 103-114.
Phenotype	PTSD Diagnostic Status at T2, Improvement in CAPS PTSD symptoms scores, Memory Performance
Trauma	Various
Study Design	Case-control (longitudinal design)
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	22 treatment-seekers diagnosed with acute PTSD (13 remitted and 9 persistent PTSD groups)
SNP/Marker Size	4 SNPs
Predominant Ethnicity	Mostly Caucasian
Population	Not mentioned
Gender	Not mentioned
Age	Mean age=33 years, SD=9.8, range from 21 to 48 years old.

Detail Info

Sample Diagnosis	DSM-IV-TR
Related Diagnostic Tools	The Peritraumatic Distress Inventory (PDI), The Peritraumatic Dissociation Experience Questionnaire (PDEQ), The Clinician-Administered PTSD Scale (CAPS), the Mini International Neuropsychiatric Interview and the Beck Depression Inventory (BDI), The Rey Auditory Verbal Learning Test (RAVLT), The Aggie Figures Learning Test (AFLT).
Sample Status	Participants were all treatment seekers, thereby explaining the high level of comorbidity. Participants were tested at the onset of their therapy (henceforth referred to as Time 1 or T1) and 6 months later (henceforth called T2 or follow-up). More detail information please see the article.
Controls Exposed	Yes
Replication Size	None
Result Summary	The present study sought to longitudinally explore this question by examining the association between four single-nucleotide polymorphisms (SNPs) in the FKBP5 gene (rs3800373, rs9470080, rs1360780, and rs9296158), the persistence of PTSD (severity and diagnostic status), and memory performance among twenty-two treatment-seekers diagnosed with acute PTSD. Results showed that the four SNPs significantly interacted with improvement in PTSD symptoms as well as PTSD diagnostic status. Individuals homozygous for the dominant allele and having experienced higher levels of peritraumatic responses subsequently showed more memory dysfunction. The results of this study suggest that SNPs in the FKBP5 gene are associated with symptom persistence and memory dysfunction in acute PTSD.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 12)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs9470080	PTSD Diagnostic Status at T2	FKBP5	(remitted vs. unremitting PTSD) recessive alleles were combined and genotype frequencies were compared using the following model: CT+TT vs. CC, T allele, X²=6.77, P-value=0.004.	These results suggest that the CC genotype at rs9470080 is a...... These results suggest that the CC genotype at rs9470080 is associated with unremitting chronic PTSD. More...	Significant
rs3800373	PTSD Diagnostic Status at T2	FKBP5	(remitted vs. unremitting PTSD) recessive alleles were combined and genotype frequencies were compared using the following model: AC+CC vs. AA, C allele, X²=8.95, P-value=0.001.	These results suggest that the AA genotype at rs3800373 is a...... These results suggest that the AA genotype at rs3800373 is associated with unremitting chronic PTSD. More...	Significant
rs9296158	PTSD Diagnostic Status at T2	FKBP5	(remitted vs. unremitting PTSD) recessive alleles were combined and genotype frequencies were compared using the following model: AG+AA vs. GG, A allele, X²=9.78, P-value<0.001.	These results suggest that the GG genotype at rs9296158 is a...... These results suggest that the GG genotype at rs9296158 is associated with unremitting chronic PTSD. More...	Significant
rs1360780	PTSD Diagnostic Status at T2	FKBP5	(remitted vs. unremitting PTSD) recessive alleles were combined and genotype frequencies were compared using the following model: CT+TT vs. CC, T allele, X²=9.78, P-value<0.001.	These results suggest that the CC genotype at rs1360780 is a...... These results suggest that the CC genotype at rs1360780 is associated with unremitting chronic PTSD. More...	Significant
rs9470080	Memory Performance	FKBP5	Relation between FKBP5 gene and memory performance at T2: r=0.02, P-value=0.94.	FKBP5 alone was not found to be associated with memory perfo...... FKBP5 alone was not found to be associated with memory performance at T2. More...	Non-significant
rs9296158	Improvement in CAPS PTSD symptoms scores	FKBP5	Linear regression: B=11.38, SE(B)=4.96, beta=0.53, P-value<0.05, R²=0.43.	A significant association of this SNP with improvement in PT...... A significant association of this SNP with improvement in PTSD symptom scores. Similar results were found when peritraumatic distress was used as a predictor instead of peritraumatic dissociation. More...	Significant
rs9470080	Improvement in CAPS PTSD symptoms scores	FKBP5	Linear regression: B=8.05, SE(B)=5.1, beta=0.38, P-value>0.05, R²=0.34.	A significant association of this SNP with improvement in PT...... A significant association of this SNP with improvement in PTSD symptom scores. Similar results were found when peritraumatic distress was used as a predictor instead of peritraumatic dissociation. More...	Non-significant
rs1360780	Memory Performance	FKBP5	Relation between FKBP5 gene and memory performance at T2: r=0.05, P-value=0.83.	FKBP5 alone was not found to be associated with memory perfo...... FKBP5 alone was not found to be associated with memory performance at T2. More...	Non-significant
rs1360780	Improvement in CAPS PTSD symptoms scores	FKBP5	Linear regression: B=11.38, SE(B)=4.96, beta=0.53, P-value<0.05, R²=0.43.	A significant association of this SNP with improvement in PT...... A significant association of this SNP with improvement in PTSD symptom scores. Similar results were found when peritraumatic distress was used as a predictor instead of peritraumatic dissociation. More...	Significant
rs3800373	Improvement in CAPS PTSD symptoms scores	FKBP5	Linear regression: B=11.61, SE(B)=5.19, beta=0.52, P-value<0.05, R²=0.43.	A significant association of this SNP with improvement in PT...... A significant association of this SNP with improvement in PTSD symptom scores. Similar results were found when peritraumatic distress was used as a predictor instead of peritraumatic dissociation. More...	Significant
rs9296158	Memory Performance	FKBP5	Relation between FKBP5 gene and memory performance at T2: r=0.05, P-value=0.83.	FKBP5 alone was not found to be associated with memory perfo...... FKBP5 alone was not found to be associated with memory performance at T2. More...	Non-significant
rs3800373	Memory Performance	FKBP5	Relation between FKBP5 gene and memory performance at T2: r=0.03, P-value=0.92.	FKBP5 alone was not found to be associated with memory perfo...... FKBP5 alone was not found to be associated with memory performance at T2. More...	Non-significant

Gene * Environment result reported by this study (count: 8)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs1360780	Memory Performance	FKBP5	Peritraumatic Responses (PDEQ, peritraumatic dissociation)	Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.50, P-value=0.04. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes CC: r=-0.67, P-value=0.03; other genotypes: r=0.03, P-value=0.94.	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDEQ (i.e., peritraumatic dissociation) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant
rs9470080	Memory Performance	FKBP5	Peritraumatic Responses (PDI, peritraumatic distress)	Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.50, P-value=0.04. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes CC: r=-0.69, P-value=0.03; other genotypes: r=0.30, P-value=0.40.	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDI (i.e., peritraumatic distress) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant
rs9296158	Memory Performance	FKBP5	Peritraumatic Responses (PDI, peritraumatic distress)	Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.51, P-value=0.03. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes GG: r=-0.69, P-value=0.02; other genotypes: r=0.35, P-value=0.35.	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDI (i.e., peritraumatic distress) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant
rs9470080	Memory Performance	FKBP5	Peritraumatic Responses (PDEQ, peritraumatic dissociation)	Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.52, P-value=0.03. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes CC: r=-0.68, P-value=0.03; other genotypes: r=0.04, P-value=0.91.	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDEQ (i.e., peritraumatic dissociation) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant
rs3800373	Memory Performance	FKBP5	Peritraumatic Responses (PDI, peritraumatic distress)	Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.52, P-value=0.03. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes AA: r=-0.69, P-value=0.02; other genotypes: r=0.39, P-value=0.35.	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDI (i.e., peritraumatic distress) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant
rs9296158	Memory Performance	FKBP5	Peritraumatic Responses (PDEQ, peritraumatic dissociation)	Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.50, P-value=0.04. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes GG: r=-0.67, P-value=0.03; other genotypes: r=0.03, P-value=0.94.	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDEQ (i.e., peritraumatic dissociation) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant
rs1360780	Memory Performance	FKBP5	Peritraumatic Responses (PDI, peritraumatic distress)	Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.51, P-value=0.03. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes CC: r=-0.69, P-value=0.02; other genotypes: r=0.35, P-value=0.35.	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDI (i.e., peritraumatic distress) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant
rs3800373	Memory Performance	FKBP5	Peritraumatic Responses (PDEQ, peritraumatic dissociation)	Association between the new GxE interaction variable and memory performance at T2 with partial correlations controlling for main effects: r=0.51, P-value=0.04. Post-hoc analyses (bivariate correlations) were conducted, the dominant homozygous genotypes AA: r=-0.67, P-value=0.03; other genotypes: r=0.14, P-value=0.75.	Significant partial correlations were found between the new ...... Significant partial correlations were found between the new G x PDEQ (i.e., peritraumatic dissociation) variable and memory performance for this SNP. These results suggest an interactive effect of FKBP5 SNPs and subjective trauma severity on memory performance. Significant negative correlations were found for individuals with the dominant homozygous genotypes. No significant correlations were found for the other genotypes. More...	Significant