||Childhood adversity (participants were asked whether, by age 13, they had witnessed or experienced a violent crime, had been sexually abused, or had been physically abused)
||5-HTTLPR genotype x childhood adversity interaction: EA, OR=1.49, 95% CI=1.07-2.08, P-value=0.019; AA, OR=0.90, 95% CI=0.60-1.35, P-value=0.62. In combined sample:EA, OR=1.52, 95% CI=1.12-2.06, P-value=0.0069; AA, OR=1.14, 95% CI=0.79-1.64, P-value=0.50.
5-HTTLPR genotype x childhood adversity interaction was sign......
5-HTTLPR genotype x childhood adversity interaction was significantly associated with lifetime PTSD diagnosis in EAs, but not in AAs. The interaction effect was calculated again after adding the diagnosis of major depressive disorder into the logistic regression model as a covariate. Including depression in the model did not change the interaction effect on PTSD. We combined the data from the current study with those from our previous study investigating the interaction effect of 5-HTTLPR and childhood adversity on PTSD risk. With the increased sample size, the power to detect the interaction effect is increased, but the effect in AAs remained non-significant. After adjusting for the effects of substance dependence, the interaction of childhood adversity and 5-HTTLPR genotype on PTSD diagnosis remained largely unchanged.