Study Report

Study Information

Basic Info
Reference |
Miller, M. W.,2018 PMID: 28867284
|
Citation |
Miller, M. W., et al. (2018). "CRP polymorphisms and DNA methylation of the AIM2 gene influence associations between trauma exposure, PTSD, and C-reactive protein." Brain Behav Immun 67: 194-202. |
Phenotype |
Current PTSD severity |
Trauma |
Combat |
Study Design |
Cross-sectional study |
Study Type |
Candidate gene association study, Gene-environment interaction study |
Sample Size |
286 samples |
SNP/Marker Size |
1 SNP |
Predominant Ethnicity |
Caucasian |
Population |
American |
Gender |
88.5% males, 11.5% females |
Age |
Mean age=31 years,SD=9 |

Detail Info
Sample Diagnosis |
DSM-IV |
Related Diagnostic Tools |
Clinician Administered PTSD Scale (CAPS) |
Sample Status |
None |
Controls Exposed |
NA |
Replication Size |
None |
Result Summary |
Methylation at the AIM2 locus. rs3091244, a functional SNP in the CRP promoter region, moderated the association between lifetime trauma exposure and current PTSD severity. |
Potential Biomarker |
We identified AIM2 DNA methylation, CRP gene variation, and CRP levels as potentially useful targets for future PTSD biomarker research and treatment development. |

Genetic result reported by this study