Study Report
Study Information
Basic Info
| Reference |
Andero, R.,2013 PMID: 23740899
|
| Citation |
Andero, R., et al. (2013). "Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD." Sci Transl Med 5(188): 188ra173. |
| Phenotype |
PTSD symptoms |
| Trauma |
Various |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study, Gene-environment interaction study |
| Sample Size |
1847 samples |
| SNP/Marker Size |
5 SNPs |
| Predominant Ethnicity |
Black |
| Population |
Primarily African American |
| Gender |
40% males, 60% females |
| Age |
Mean age=40 years |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
PTSD Symptom Scale (PSS), Clinician-Administered PTSD Scale (CAPS), other phenotype measurements included in the data collection were the CTQ as our primary child abuse measure, and current substance abuse. |
| Sample Status |
None |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
SNP rs6010719 was associated with increased PTSD symptoms in individuals exposed to moderate to severe child abuse, after controlling for age, sex, and substance abuse rs6010719 remained significant in the interaction. |
| Potential Biomarker |
None |
Genetic result reported by this study
Gene * Environment result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Environment |
Statistical Values |
Author Comments |
Marker's Category |
|
rs6010719
|
PTSD symptoms |
OPRL1 |
Childhood trauma |
F=6.4; P-value<0.005; after controlling for age, sex, and substance abuse: F=6.9; P-value<=0.001. |
SNP rs6010719 was associated with increased PTSD symptoms in......
SNP rs6010719 was associated with increased PTSD symptoms in individuals exposed to moderate to severe child abuse, after controlling for age, sex, and substance abuse rs6010719 remained significant in the interaction.
More...
|
Significant |
