Gene Report

Basic Info

Approved Symbol	ADCYAP1R1
Symbol Alias	"PAC1\|PACAPR\|PAC1R"
Approved Name	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Name Alias	PACAP receptor 1
Location	7p14.3
Position	chr7:31052461-31111479, 1
External Links	HGNC: 242 Entrez Gene: 117 Ensembl: ENSG00000078549 UCSC: uc003tcg.3
No. of Association Results	19 (Positive: 8; Negative: 11; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 19)

Reference	Phenotype	Marker	Gene's Category
Wang, L.,2013	Anxious arousal symptoms	rs2267735	Non-significant
Wang, L.,2013	Avoidance symptoms	rs2267735	Non-significant
Ressler, K. J.,2011	Dark enhanced startle	rs2267735	Significant
Rothbaum, B. O.,2014	Diagnosis of PTSD at week 12	rs2267735	Significant
Wang, L.,2013	Dysphoric arousal symptoms	rs2267735	Non-significant
Wang, L.,2013	Emotional numbing symptoms	rs2267735	Significant
Ressler, K. J.,2011	Fear Discrimination	rs2267735	Significant
Uddin, M.,2013	Past month PTS severity	rs2267735	Non-significant
Uddin, M.,2013	Past month PTSD	rs2267735	Non-significant
Ressler, K. J.,2011	PSS hyperarousal score	rs2267735	Significant
Ressler, K. J.,2011	PSS total score	rs2267735	Significant
Nievergelt, C. M.,2015	PTSD	rs6968349	Significant
Ressler, K. J.,2011	PTSD diagnosis	rs10081254 ; rs10241138 ; rs10268647 ; rs10269014 ; rs10277350 ; rs11979764 ; rs12670977 ; rs12670991 ; rs1541516 ; rs1541518 ; rs17159861 ; rs17723231 ; rs1981701 ; rs2041568 ; rs2267727 ; rs2267733 ; rs2267735 ; rs2267737 ; rs2267738 ; rs2267740 ; rs4503014 ; rs741051 ; rs7784067 ; rs7786118 ; rs7804302 ; rs7804958 ; rs7805043	Significant
Solovieff, N.,2014	PTSD diagnosis	rs10226318	Non-significant
Solovieff, N.,2014	PTSD severity	rs2284225	Non-significant
Almli, L. M.,2013	PTSD symptom severity	rs2267735	Non-significant
Wang, L.,2013	PTSD symptoms	rs2267735	Non-significant
Rothbaum, B. O.,2014	PTSD symptoms at week 4	rs2267735	Non-significant
Wang, L.,2013	Reexperiencing symptoms	rs2267735	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Uddin, M.,2013	Correlations between chlidhood maltreatment and past month PTS severity	Childhood maltreatment (CM)	rs2267735 ; rs6968349	Significant

Gene functional annotation

Gene related GO terms (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007283	spermatogenesis	biological process	IEA	7
GO:0005768	endosome	cellular component	IEA	5
GO:0004999	vasoactive intestinal polypeptide receptor activity	molecular function	IEA	2
GO:0008179	adenylate cyclase binding	molecular function	IEA	2
GO:0030306	ADP-ribosylation factor binding	molecular function	IEA	1
GO:0004872	receptor activity	molecular function	TAS[7902709]	4
GO:0009986	cell surface	cellular component	IEA	21
GO:0005887	integral component of plasma membrane	cellular component	TAS[7902709]	36
GO:0005923	bicellular tight junction	cellular component	IEA	5
GO:0032355	response to estradiol	biological process	IEA	9
GO:0010524	positive regulation of calcium ion transport into cytosol	biological process	IEA	1
GO:0045471	response to ethanol	biological process	IEA	18
GO:0043005	neuron projection	cellular component	IEA	17
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[7902709]	16
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	14
GO:0007202	activation of phospholipase C activity	biological process	IEA	4
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0042923	neuropeptide binding	molecular function	IEA	2
GO:0060548	negative regulation of cell death	biological process	IEA	1
GO:0033555	multicellular organismal response to stress	biological process	IEA	2
GO:0042493	response to drug	biological process	IEA	25
GO:0043235	receptor complex	cellular component	IDA[23382219]	3
GO:0005515	protein binding	molecular function	IPI[17470806]	169
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	TAS	4
GO:0046545	development of primary female sexual characteristics	biological process	IEA	1
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	11
GO:0019933	cAMP-mediated signaling	biological process	IEA	4
GO:0007190	activation of adenylate cyclase activity	biological process	TAS	6
GO:0030154	cell differentiation	biological process	IEA	10
GO:0005901	caveola	cellular component	IEA	7
GO:0005791	rough endoplasmic reticulum	cellular component	IEA	2
GO:0060732	positive regulation of inositol phosphate biosynthetic process	biological process	IEA	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 1)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
ADCYAP1R1	CALM1	No	--	--	15670850 , 15670850 , 15670850 , 15670850