PTSDgene database

SNP Report

Basic Info
Name rs2437772 dbSNP Ensembl
Location 8:96500749 - 96500749(+)
Variant Seq T
Ancestral Allele T
Ref Seq C
Minor Allele Frequence 0.252596
Annotation intron_variant; non_coding_transcript_variant
Variant Effect intron_variant(ENST00000522911, ENST00000518385, ENST00000302190, ENST00000519587, ENST00000520233); non_coding_transcript_variant(ENST00000519587, ENST00000520233)
SIFT Annotation deleterious; tolerated
SIFT Variant Effect deleterious(ENST00000518385); tolerated(ENST00000302190)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000518385, ENST00000302190)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Enhancers
No. of Marker's Association Results 1 (Positive: 0; Negative: 0; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Ashley-Koch, A. E.,2015 Current PTSD In NHW subset: OR=0.56, main effect P-value=6.36E-06. In NHW subset: OR=0.56, main effect P-value=6.36E-06. This SNP was nominally significant with current PTSD among t...... This SNP was nominally significant with current PTSD among the NHW subset (P-value More... Trend
G*E study related association result (count: 2)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Ashley-Koch, A. E.,2015 Current PTSD Childhood trauma Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and child trauma interaction P-value=0.56. More... We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More... Non-significant
Ashley-Koch, A. E.,2015 Current PTSD NTE (number of traumatic events) Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and total trauma interaction P-value=0.26. More... We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
SDC2 syndecan 2 8q22-q23 1(0/0/1)

SNPs in LD with rs2437772 (count: 8)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 8)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-259G18.3 No Adipose Subcutaneous cis GTEx