SNP Report

Basic Info

Name	rs1334894 dbSNP Ensembl
Location	6:35647353 - 35647353(+)
Variant Seq	T
Ancestral Allele	C
Ref Seq	C
Minor Allele Frequence	0.0567093
Annotation	upstream_gene_variant; intron_variant
Variant Effect	upstream_gene_variant(ENST00000391277); intron_variant(ENST00000542713, ENST00000536438, ENST00000539068, ENST00000357266)
SIFT Annotation	deleterious; tolerated
SIFT Variant Effect	deleterious(ENST00000542713); tolerated(ENST00000539068, ENST00000357266, ENST00000536438)
PolyPhen Annotation	benign
PolyPhen Variant Effect	benign(ENST00000539068, ENST00000542713, ENST00000357266, ENST00000536438)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	TF binding region
Chromatin State	Enhancers;Weak transcription;Strong transcription;Genic enhancers
No. of Marker's Association Results	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Binder, E. B.,2008	PTSD Symptoms (PSS scores)	No available detail information. No available detail information.	We found no significant main effect of FKBP5 genotypes on PS...... We found no significant main effect of FKBP5 genotypes on PSS total score. More...	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Statistical Values	Author Comments	Marker's Category
Binder, E. B.,2008	PTSD Symptoms (PSS scores)	Child abuse	No available detail information. No available detail information.	No significant signals was observed about this SNP's interac...... No significant signals was observed about this SNP's interaction of FKBP5 with child abuse to predict PTSD symptoms. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
FKBP5	FK506 binding protein 5	6p21.31	25(12/13/0)

SNPs in LD with rs1334894 (count: 39)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 39)

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs72913412	rs1334894	downstream_gene_variant	0.8677[AMR]
rs55791123	rs1334894	upstream_gene_variant	1.0000[AFR]
rs2103680	rs1334894	downstream_gene_variant; upstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0000[AFR]
rs12527329	rs1334894	intron_variant	1.0000[AFR]; 0.9546[AMR]
rs1807142	rs1334894	non_coding_transcript_exon_variant; non_coding_transcript_variant	0.8067[AMR]
rs56313753	rs1334894	upstream_gene_variant	1.0000[AFR]
rs72894781	rs1334894	downstream_gene_variant; intron_variant	1.0000[AFR]
rs72921231	rs1334894	intron_variant	1.0000[AFR]; 0.9546[AMR]
rs56062505	rs1334894	upstream_gene_variant	1.0000[AFR]
rs72911397	rs1334894	downstream_gene_variant	1.0000[AFR]
rs12527893	rs1334894	intron_variant	1.0000[AFR]; 0.9546[AMR]
rs7754668	rs1334894	intron_variant	1.0000[AFR]; 0.9546[AMR]
rs6906096	rs1334894	upstream_gene_variant	1.0000[AFR]
rs56318292	rs1334894	downstream_gene_variant	1.0000[AFR]; 0.9098[AMR]
rs12529688	rs1334894	intron_variant; non_coding_transcript_variant	1.0000[AFR]
rs72913417	rs1334894	downstream_gene_variant; intron_variant	0.9098[AMR]
rs2294807	rs1334894	intron_variant	0.9098[AMR]
rs56353810	rs1334894	upstream_gene_variant	1.0000[AFR]
rs72913427	rs1334894	intron_variant	1.0000[AFR]; 0.9546[AMR]
rs16877540	rs1334894	downstream_gene_variant	1.0000[AFR]
rs72899794	rs1334894	downstream_gene_variant	1.0000[AFR]
rs72899796	rs1334894	downstream_gene_variant	1.0000[AFR]
rs9688674	rs1334894	downstream_gene_variant; upstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0000[AFR]
rs7756437	rs1334894	intron_variant	1.0000[AFR]; 0.9323[AMR]
rs55922240	rs1334894	intron_variant	1.0000[AFR]; 0.9546[AMR]
rs1883637	rs1334894	upstream_gene_variant; intron_variant	1.0000[AFR]
rs72913423	rs1334894	non_coding_transcript_exon_variant; intron_variant; non_coding_transcript_variant	1.0000[AFR]; 0.9546[AMR]
rs72911394	rs1334894	downstream_gene_variant	1.0000[AFR]; 0.8067[AMR]
rs72913405	rs1334894	downstream_gene_variant	1.0000[AFR]; 0.9098[AMR]
rs12526404	rs1334894	upstream_gene_variant	1.0000[AFR]
rs747411	rs1334894	intron_variant	1.0000[AFR]; 0.9546[AMR]
rs12528458	rs1334894	upstream_gene_variant	1.0000[AFR]
rs10498734	rs1334894	intron_variant	1.0000[AFR]; 0.9546[AMR]
rs12665445	rs1334894	downstream_gene_variant; upstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0000[AFR]
rs72894784	rs1334894	downstream_gene_variant; intron_variant	1.0000[AFR]
rs11545925	rs1334894	3_prime_UTR_variant	0.9098[AMR]
rs9689799	rs1334894	downstream_gene_variant; upstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0000[AFR]
rs12527303	rs1334894	upstream_gene_variant	1.0000[AFR]
rs755658	rs1334894	3_prime_UTR_variant; intron_variant	0.9098[AMR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
CRHR1	Yes	Adipose Subcutaneous	cis	GTEx