Gene Report

Basic Info

Approved Symbol	DRD2
Approved Name	dopamine receptor D2
Location	11q23.2
Position	chr11:113409615-113475691, -1
External Links	HGNC: 3023 Entrez Gene: 1813 Ensembl: ENSG00000149295 UCSC: uc001poa.4
No. of Association Results	18 (Positive: 11; Negative: 7; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 18)

Reference	Phenotype	Marker	Gene's Category
Tian, Y.,2015	PTSD	DRD2_Taq 1	Significant
Young, R. M.,2002	PTSD	DRD2_Taq I A alleles	Significant
Duan, Z.,2015	PTSD diagnosis	rs10891556 - rs1799978 - rs4648317 - rs7131056 - rs4460839 - rs12574471 - rs4648319 - rs4648318 - rs4586205 - rs4436578 - rs2075652 - rs2734833 - rs6279 - rs2242591 - rs1800479, GTGATCATTTGGCTA ; rs10891556 - rs1799978 - rs4648317 - rs7131056 - rs4460839 - rs12574471 - rs4648319 - rs4648318 - rs4586205 - rs4436578 - rs2075652 - rs2734833 - rs6279 - rs2242591 - rs1800479, GTGATCGCGCAGGCG ; rs10891556 - rs1799978 - rs4648317 - rs7131056 - rs4460839 - rs12574471 - rs4648319 - rs4648318 - rs4586205 - rs4436578 - rs2075652 - rs2734833 - rs6279 - rs2242591 - rs1800479, TTACTCATTTGGCTA ; rs10891556 - rs1799978 - rs4648317 - rs7131056 - rs4460839 - rs12574471 - rs4648319 - rs4648318 - rs4586205 - rs4436578 - rs2075652 - rs2734833 - rs6279 - rs2242591 - rs1800479, TTACTCGCGCAGGCG ; rs10891556 ; rs12574471 ; rs1799978 ; rs1800479 ; rs2075652 ; rs2242591 ; rs2734833 ; rs4436578 ; rs4460839 ; rs4586205 ; rs4648317 ; rs4648318 ; rs4648319 ; rs6279 ; rs7131056	Significant
Comings, D. E.,1996	Avoidance of trauma-associated stimuli	rs1800497	Significant
Comings, D. E.,1996	Increased hyperreactivity and vigilance	rs1800497	Significant
Nelson, E. C.,2014	PTSD	rs12364283 ; rs12805897 ; rs4648317	Significant
Voisey, J.,2009	PTSD	rs1799732 ; rs1800497 ; rs6277	Significant
Nievergelt, C. M.,2015	PTSD	rs75924850	Significant
Bailey, J. N.,2010	PTSD category B symptom score	rs1800497	Non-significant
Bailey, J. N.,2010	PTSD category C symptom score	rs1800497	Non-significant
Solovieff, N.,2014	PTSD diagnosis	rs1124492	Non-significant
Comings, D. E.,1996	PTSD diagnosis	rs1800497	Significant
Gelernter, J.,1999	PTSD diagnosis	rs1800497	Non-significant
Bailey, J. N.,2010	PTSD diagnosis	rs1800497	Non-significant
Solovieff, N.,2014	PTSD severity	rs4274224	Non-significant
Bailey, J. N.,2010	PTSD symptoms	rs1800497	Non-significant
Comings, D. E.,1996	Reexperiencing of the traumatic events	rs1800497	Significant
Comings, D. E.,1996	Total PTSD score	rs1800497	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs75924850 ; DRD2_Taq 1	Non-significant

Gene functional annotation

Gene related GO terms (count: 117)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0051898	negative regulation of protein kinase B signaling	biological process	ISS	2
GO:0007626	locomotory behavior	biological process	ISS	9
GO:0021756	striatum development	biological process	IEA	1
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	biological process	ISS	1
GO:0048149	behavioral response to ethanol	biological process	IBA; ISS	4
GO:1900168	positive regulation of glial cell-derived neurotrophic factor secretion	biological process	IDA[23373701]	1
GO:0008285	negative regulation of cell proliferation	biological process	ISS	13
GO:0051967	negative regulation of synaptic transmission, glutamatergic	biological process	IBA; ISS	2
GO:0090325	regulation of locomotion involved in locomotory behavior	biological process	IEA	2
GO:0043204	perikaryon	cellular component	IEA	6
GO:0033602	negative regulation of dopamine secretion	biological process	IEA	2
GO:0040018	positive regulation of multicellular organism growth	biological process	IEA	3
GO:0036126	sperm flagellum	cellular component	IEA	1
GO:0016055	Wnt signaling pathway	biological process	IEA	3
GO:0043679	axon terminus	cellular component	IEA	6
GO:0014059	regulation of dopamine secretion	biological process	IBA	6
GO:0043197	dendritic spine	cellular component	IEA	9
GO:0004935	adrenergic receptor activity	molecular function	IBA	1
GO:0009636	response to toxic substance	biological process	IBA	10
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	molecular function	IDA[2531656\|8301582]	3
GO:0001659	temperature homeostasis	biological process	ISS	2
GO:0031223	auditory behavior	biological process	IEA	1
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	biological process	IDA[1331329]	1
GO:0008542	visual learning	biological process	ISS	6
GO:0032467	positive regulation of cytokinesis	biological process	IMP[22888021]	2
GO:0005829	cytosol	cellular component	IBA; IDA[1331329]; IEA	78
GO:0001963	synaptic transmission, dopaminergic	biological process	IBA	5
GO:0002031	G-protein coupled receptor internalization	biological process	IEA	3
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	biological process	ISS	2
GO:0045776	negative regulation of blood pressure	biological process	ISS	5
GO:0031513	nonmotile primary cilium	cellular component	IDA[20531939]	1
GO:0034776	response to histamine	biological process	IDA[16839358]	3
GO:0042417	dopamine metabolic process	biological process	IC[8301582]	4
GO:0006874	cellular calcium ion homeostasis	biological process	IC[7921596]	9
GO:0007194	negative regulation of adenylate cyclase activity	biological process	IDA[2531656]; IEA	5
GO:0007616	long-term memory	biological process	IEA	3
GO:0030672	synaptic vesicle membrane	cellular component	IBA	3
GO:0042220	response to cocaine	biological process	ISS	7
GO:0048755	branching morphogenesis of a nerve	biological process	ISS	1
GO:0048169	regulation of long-term neuronal synaptic plasticity	biological process	ISS	2
GO:0042802	identical protein binding	molecular function	IPI[18668123]	10
GO:0007628	adult walking behavior	biological process	ISS	3
GO:0046676	negative regulation of insulin secretion	biological process	IEA	2
GO:0007608	sensory perception of smell	biological process	ISS	3
GO:0014854	response to inactivity	biological process	IEA	2
GO:0014069	postsynaptic density	cellular component	IEA	11
GO:0032147	activation of protein kinase activity	biological process	IEA	1
GO:0030432	peristalsis	biological process	ISS	1
GO:0035810	positive regulation of urine volume	biological process	IEA	2
GO:0008104	protein localization	biological process	ISS	4
GO:0009416	response to light stimulus	biological process	ISS	2
GO:0016328	lateral plasma membrane	cellular component	IEA	2
GO:0030336	negative regulation of cell migration	biological process	ISS	1
GO:0042803	protein homodimerization activity	molecular function	IEA	18
GO:0060124	positive regulation of growth hormone secretion	biological process	ISS	3
GO:0007409	axonogenesis	biological process	ISS	6
GO:0048148	behavioral response to cocaine	biological process	IBA; ISS	5
GO:0043266	regulation of potassium ion transport	biological process	IBA; ISS	2
GO:0035556	intracellular signal transduction	biological process	IDA[1331329]	10
GO:0021853	cerebral cortex GABAergic interneuron migration	biological process	ISS	1
GO:0043473	pigmentation	biological process	IEA	2
GO:0046488	phosphatidylinositol metabolic process	biological process	ISS	1
GO:0001669	acrosomal vesicle	cellular component	IEA	1
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	biological process	IGI[17194762]	1
GO:0008144	drug binding	molecular function	IDA[8413587]	13
GO:0030424	axon	cellular component	ISS	16
GO:0050482	arachidonic acid secretion	biological process	IDA[8301582]	3
GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	biological process	IEA	1
GO:0008306	associative learning	biological process	ISS	2
GO:0007631	feeding behavior	biological process	IEA	3
GO:0051584	regulation of dopamine uptake involved in synaptic transmission	biological process	IC[8301582]	2
GO:0021984	adenohypophysis development	biological process	ISS	2
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	25
GO:0002052	positive regulation of neuroblast proliferation	biological process	ISS	1
GO:0030139	endocytic vesicle	cellular component	IEA	4
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	biological process	IBA	2
GO:0005515	protein binding	molecular function	IPI[10692483\|12297500\|17380124\|19632986]	169
GO:0042493	response to drug	biological process	IBA; ISS	25
GO:0010039	response to iron ion	biological process	IEA	2
GO:0046982	protein heterodimerization activity	molecular function	IEA	10
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway	biological process	IEA	1
GO:0032922	circadian regulation of gene expression	biological process	ISS	4
GO:0051481	negative regulation of cytosolic calcium ion concentration	biological process	IBA	2
GO:0002028	regulation of sodium ion transport	biological process	ISS	2
GO:0048678	response to axon injury	biological process	IEA	2
GO:0021769	orbitofrontal cortex development	biological process	IEA	1
GO:0032228	regulation of synaptic transmission, GABAergic	biological process	ISS	2
GO:0007416	synapse assembly	biological process	ISS	4
GO:0050709	negative regulation of protein secretion	biological process	IDA[16839358]	4
GO:0045824	negative regulation of innate immune response	biological process	IEA	1
GO:0060170	ciliary membrane	cellular component	IDA[20531939]	1
GO:0001975	response to amphetamine	biological process	ISS	9
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	biological process	IDA[1331329\|2531656]; IEA	3
GO:0051823	regulation of synapse structural plasticity	biological process	IEA	1
GO:0007625	grooming behavior	biological process	IEA	1
GO:0051209	release of sequestered calcium ion into cytosol	biological process	ISS	3
GO:0060134	prepulse inhibition	biological process	ISS	4
GO:0035255	ionotropic glutamate receptor binding	molecular function	IEA	2
GO:0007270	neuron-neuron synaptic transmission	biological process	ISS	1
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0035815	positive regulation of renal sodium excretion	biological process	IEA	2
GO:0035240	dopamine binding	molecular function	IBA	6
GO:0005887	integral component of plasma membrane	cellular component	IC[2531656]; IDA[8413587]	36
GO:0043278	response to morphine	biological process	ISS	6
GO:0002092	positive regulation of receptor internalization	biological process	IEA	2
GO:1900273	positive regulation of long-term synaptic potentiation	biological process	IEA	2
GO:0001666	response to hypoxia	biological process	IEA	13
GO:0060160	negative regulation of dopamine receptor signaling pathway	biological process	ISS	2
GO:0005622	intracellular	cellular component	IDA[1331329]	15
GO:0015459	potassium channel regulator activity	molecular function	NAS[12297500]	4
GO:0030425	dendrite	cellular component	ISS	19
GO:0035094	response to nicotine	biological process	IEA	11
GO:0002027	regulation of heart rate	biological process	ISS	2
GO:1901386	negative regulation of voltage-gated calcium channel activity	biological process	IDA[7921596]; IEA	4
GO:0030814	regulation of cAMP metabolic process	biological process	IDA[8666994]	2
GO:0043666	regulation of phosphoprotein phosphatase activity	biological process	IEA	1
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IEA	10

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in PTSDgene
hsa04540	Gap junction	6
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 19)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
DRD2	FLNA	No	coimmunoprecipitation	--	11911837 , 12181426 , 11320256
DRD2	GNAZ	No	--	--	9166747
DRD2	KCNJ9	No	--	--	12297500
DRD2	PAWR	No	--	--	16051151 , 16051151
DRD2	EPB41L1	No	--	--	12181426 , 12181426 , 12181426
DRD2	KCNJ6	No	--	--	12297500 , 12297500
DRD2	CADPS	No	--	--	15857609
DRD2	SLC6A3	Yes	--	--	17380124 , 17380124 , 17380124 , 17380124 , 17380124 , 17380124 , 17380124 , 17380124 , 17380124 , 17380124 , 17380124 , 17380124 , 17380124
DRD2	CALM1	No	--	colocalization	19632986 , 19632986 , 16051151
DRD2	GRIA2	No	--	--	15858065 , 15858065
DRD2	KCNJ5	No	--	--	12297500
DRD2	NSF	No	--	--	15858065
DRD2	CLIC6	No	--	--	14499480 , 14499480
DRD2	NCS1	No	--	--	12351722 , 12351722 , 12351722 , 12351722 , 12351722 , 12351722
DRD2	CADPS2	No	--	--	15857609
DRD2	PPP1R9B	No	--	--	17464283 , 10391935 , 17464283 , 17464283 , 17464283 , 10391935 , 10391935
DRD2	ADORA2A	No	--	association	12804599 , 19632986 , 12804599 , 12804599 , 19632986
DRD2	KCNJ3	No	--	--	12297500
DRD2	SSTR5	No	--	--	10753124