PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Lyons, M. J., et al. (2013). "Gene-environment interaction of ApoE genotype and combat exposure on PTSD." Am J Med Genet B Neuropsychiatr Genet 162B(7): 762-769.
Phenotype PTSD Symptomatology, PTSD diagnosis
Trauma Combat
Study Design Case-control
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 172 participants (there were 170 participants with complete diagnostic, genotypic, and combat exposure data among them:39 PTSD and 131 without PTSD)
SNP/Marker Size 1 Variant
Predominant Ethnicity Caucasian, Black
Population 92.3% White, 4.2% African-American, and 3.5% "other."
Gender all male
Age an average age=55 years in all VETSA participants (N=1237)

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
APOE_euro4 PTSD diagnosis APOE Secondary analyses, N=170, main effect for APOE genotype, B=1.1265, P-value=0.58 (signif from GEE). The main effect for apoE genotype was not significant in pre...... The main effect for apoE genotype was not significant in predicting the diagnosis of PTSD. More... Non-significant
APOE_euro4 PTSD symptomatology APOE Primary anlalyses, linear model, N=172, main effects for APOE genotype: B=-1.766, P-value=0.02. The main effect for apoE genotype was significant in primary...... The main effect for apoE genotype was significant in primary analyses. More... Significant

Gene * Environment result reported by this study (count: 2)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
APOE_euro4 PTSD Symptomatology APOE Combat exposure Primary anlalyses, N=172, interaction between combat exposure and APOE genotype: B=0.529, P-value=0.014 (signif from GEE). Using only White, non-Hispanic participants: P-value=0.008. The interaction of combat exposure and apoE genotype was sig...... The interaction of combat exposure and apoE genotype was significant in primary anlalyses. The interaction between combat exposure and apoE genotype remained a significant predictor of the number of PTSD symptoms using only White, non-Hispanic participants. More... Significant
APOE_euro4 Diagnosis of PTSD APOE Combat exposure Secondary anlalyses, N=170, interaction between combat exposure and APOE genotype: B=1.534, P-value=0.009 (signif from GEE). Using only White, non-Hispanic participants: P-value=0.001 The interaction of combat exposure and apoE genotype was sig...... The interaction of combat exposure and apoE genotype was significant in secondary anlalyses for dianosis of PTSD. The interaction between combat exposure and apoE genotype remained a significant predictor of the diagnosis of PTSD using only White, non-Hispanic participants. More... Significant