Gene Report

Basic Info

Approved Symbol	NR3C1
Previous Symbol	GRL
Symbol Alias	GR
Approved Name	nuclear receptor subfamily 3 group C member 1
Previous Name	"nuclear receptor subfamily 3, group C, member 1\|nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)"
Name Alias	glucocorticoid receptor
Location	5q31-q32
Position	chr5:143277931-143435512, -1
External Links	HGNC: 7978 Entrez Gene: 2908 Ensembl: ENSG00000113580 UCSC: uc003lnb.3
No. of Association Results	6 (Positive: 2; Negative: 4; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 6)

Reference	Phenotype	Marker	Gene's Category
Bachmann, A. W.,2005	PTSD diagnosis	GR_exon 2_N363S ; GR_exon_R23K ; GR_intron 2_Bcl1	Non-significant
Hauer, D.,2011	PTSD stress symptom scores	GR_intron 2_Bcl1	Significant
Lian, Y.,2014	PTSD	rs10482605 ; rs258747 ; rs41423247	Significant
Nievergelt, C. M.,2015	PTSD	rs79590198	Non-significant
Solovieff, N.,2014	PTSD diagnosis	rs7701443	Non-significant
Solovieff, N.,2014	PTSD severity	rs7701443	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs79590198	Significant

Gene functional annotation

Gene related GO terms (count: 35)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0006355	regulation of transcription, DNA-templated	biological process	IDA[19141540]	14
GO:0046983	protein dimerization activity	molecular function	IEA	5
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[15769988\|16728402\|23823477]	25
GO:0005737	cytoplasm	cellular component	IDA[15769988\|17635946]	109
GO:0007165	signal transduction	biological process	TAS[7769088]	34
GO:0010467	gene expression	biological process	TAS	16
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular function	IDA[15769988\|17635946]	9
GO:0006351	transcription, DNA-templated	biological process	TAS[10887960]	21
GO:0006111	regulation of gluconeogenesis	biological process	IEA	1
GO:0005496	steroid binding	molecular function	IDA[15769988]	2
GO:0005634	nucleus	cellular component	IDA[15769988\|17635946\|23878391]	81
GO:0043402	glucocorticoid mediated signaling pathway	biological process	IEA	1
GO:0043525	positive regulation of neuron apoptotic process	biological process	IEA	3
GO:0005759	mitochondrial matrix	cellular component	TAS[10887960]	6
GO:0060603	mammary gland duct morphogenesis	biological process	IEA	1
GO:1990239	steroid hormone binding	molecular function	IDA[17635946]	1
GO:0042921	glucocorticoid receptor signaling pathway	biological process	IEA	1
GO:0006366	transcription from RNA polymerase II promoter	biological process	TAS[8621628]	6
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	5
GO:0005829	cytosol	cellular component	IEA	78
GO:0008270	zinc ion binding	molecular function	IEA	26
GO:0016568	chromatin modification	biological process	IEA	2
GO:0042711	maternal behavior	biological process	IEA	3
GO:0008211	glucocorticoid metabolic process	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[9079630\|10364267\|11266503\|12552091\|12773562\|15591535\|15769988\|15941832\|16606617\|16619302\|16888650\|17003263\|17635946\|17978169\|19141540\|20195357\|21980503\|22170608\|23339905\|24291004\|24658140\|24949977]	169
GO:0030325	adrenal gland development	biological process	IEA	2
GO:0071383	cellular response to steroid hormone stimulus	biological process	IDA[15769988\|17635946]	1
GO:0004883	glucocorticoid receptor activity	molecular function	TAS[8621628]	1
GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	molecular function	IDA[16728402\|23823477]	2
GO:0031946	regulation of glucocorticoid biosynthetic process	biological process	IEA	1
GO:1900170	negative regulation of glucocorticoid mediated signaling pathway	biological process	IEA	1
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IDA[16728402]	3
GO:0038051	glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity	molecular function	IDA[17635946]	1
GO:0016020	membrane	cellular component	IEA	42
GO:0005654	nucleoplasm	cellular component	IDA; TAS	43

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 179)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
NR3C1	MAPK8	No	--	--	16888650 , 12351702
NR3C1	DAXX	No	--	--	12595526 , 17081986 , 17081986 , 12595526 , 12595526
NR3C1	COPS6	No	--	--	12237292
NR3C1	MDM2	No	--	--	11562347 , 11562347 , 11562347
NR3C1	PTPRN2	No	--	--	20195357
NR3C1	RBM14	No	--	--	20211142
NR3C1	RXRB	No	--	--	20211142
NR3C1	CD3D	No	--	--	16888650 , 16888650 , 16888650
NR3C1	ALDH5A1	No	--	--	20195357
NR3C1	GNB2	No	--	--	15955845
NR3C1	DDX54	No	--	--	12466272 , 12466272
NR3C1	HMGB2	No	--	--	9671457
NR3C1	TTC3	No	--	--	20195357
NR3C1	EIF4A2	No	--	--	20195357
NR3C1	ONECUT1	No	--	--	10430878 , 10430878
NR3C1	POU2F2	No	--	--	9584182 , 10490647 , 10480874 , 10490647
NR3C1	CREB1	No	--	--	8449898 , 7621901
NR3C1	p53	No	--	--	11562347 , 11080152 , 11562347 , 11562347 , 11080152 , 11562347
NR3C1	PBX1	No	--	--	12487626 , 12487626
NR3C1	ATP1B1	No	--	--	20195357
NR3C1	KDM5A	No	--	--	11358960 , 11358960
NR3C1	DAP3	No	--	--	10903152 , 12099703 , 10903152 , 10903152
NR3C1	NCOA4	No	--	--	10517667
NR3C1	ELAVL1	No	--	--	19322201
NR3C1	RAD9A	No	--	--	14966297
NR3C1	TRIM28	No	biochemical	colocalization	9742105 , 22863883 , 9742105 , 9742105
NR3C1	TXN	No	--	--	9915858 , 9915858 , 9915858
NR3C1	SF3A1	No	biochemical	colocalization	22863883
NR3C1	PML	No	--	--	20211142
NR3C1	SMARCA4	No	biochemical, coimmunoprecipitation	colocalization	10688647 , 12917342 , 9590696 , 9128241 , 17387179 , 9590696
NR3C1	HSPD1	No	--	--	10508170
NR3C1	YWHAH	No	--	--	9079630 , 9079630 , 9079630
NR3C1	NR3C2	No	--	--	11154266 , 11154266 , 11154266
NR3C1	SYT1	No	--	--	16143103
NR3C1	PPP5C	No	--	--	9195923 , 20661446
NR3C1	EPB41L3	No	--	--	20195357
NR3C1	AR	No	--	--	9162033
NR3C1	FKBP4	No	--	--	8341706 , 8341706 , 20661446 , 11751894
NR3C1	POU2F1	No	--	--	14522952 , 10480874 , 9584182 , 10490647 , 9584182 , 10490647
NR3C1	PPARG	No	--	--	15531761
NR3C1	PSMC3IP	No	--	--	11739747 , 11739747
NR3C1	TSPYL2	No	--	--	20195357
NR3C1	ANP32A	No	--	--	20195357
NR3C1	SET	No	--	--	18096310 , 18096310
NR3C1	SRSF5	No	--	--	20195357
NR3C1	PPARGC1A	No	--	--	18160712 , 10713165 , 10713165
NR3C1	MLL	No	--	--	20195357
NR3C1	ASXL1	No	--	--	16606617 , 16606617
NR3C1	NFKB2	No	--	--	7823959 , 7823959
NR3C1	ZNF483	No	--	--	20195357
NR3C1	HDAC6	No	--	--	20018896 , 20018896 , 20018896
NR3C1	ZBTB20	No	--	--	20211142
NR3C1	NCOA1	No	--	--	16606617 , 10731636 , 16606617 , 10659697 , 9590696 , 11266503 , 12917342 , 12118039
NR3C1	MSX2	No	--	--	20211142
NR3C1	c-Jun	No	--	--	8733011 , 14522952 , 14522952
NR3C1	HDAC2	No	--	--	10958685
NR3C1	SMARCE1	No	--	--	12917342 , 12917342
NR3C1	SLC25A4	No	--	--	12039962
NR3C1	NR2F6	No	--	--	10713182 , 10713182
NR3C1	DNAJC7	No	--	--	20661446
NR3C1	TDG	No	--	--	12874288
NR3C1	HDAC1	No	biochemical	colocalization	22863883 , 15826950 , 16762839
NR3C1	NCOA3	No	--	--	12917342 , 18160712 , 11266503
NR3C1	NCOA6	No	--	--	10866662 , 10567404 , 10866662 , 10866662
NR3C1	SUMO1	No	--	--	12193561 , 18562626 , 17081986
NR3C1	TSG101	No	--	--	10508170 , 10508170 , 15657031 , 15657031
NR3C1	PSMD7	No	--	--	12237292
NR3C1	CREBBP	No	--	--	20018896 , 9649342 , 9649342 , 9649342 , 20018896 , 20018896 , 9590696
NR3C1	CD2AP	No	biochemical	colocalization	22863883
NR3C1	NEDD4L	No	--	--	9649342
NR3C1	NCL	No	--	--	11162542 , 11162542
NR3C1	NR2E3	No	--	--	20211142
NR3C1	NCOR2	No	--	--	12011091 , 12011091 , 15870285
NR3C1	KTN1	No	--	--	20195357
NR3C1	ZHX1	No	--	--	20195357
NR3C1	PHF3	No	--	--	20195357
NR3C1	NR1H3	No	--	--	22457708
NR3C1	NRIP1	No	--	--	10659697 , 12773562 , 12773562 , 11266503 , 10659697 , 9920921 , 10364267 , 12773562 , 11266503
NR3C1	MAPK15	No	--	--	16624805
NR3C1	SFN	No	--	colocalization	12730237 , 12730237 , 12730237 , 12730237 , 12730237 , 12730237 , 12730237 , 12730237
NR3C1	SMARCB1	No	--	--	10688647
NR3C1	GAPVD1	No	biochemical	colocalization	22863883
NR3C1	GRIP1	No	--	--	16362036 , 16362036 , 16362036 , 16423881 , 16362036
NR3C1	GNB1	No	--	--	15955845
NR3C1	RNF14	Yes	--	--	10085091
NR3C1	HNRNPA1	No	--	--	15604093
NR3C1	CEBPA	No	--	--	9817600 , 11818365
NR3C1	UBC	No	--	--	12490527 , 15761032 , 21963094 , 23493285 , 11555652 , 11562347 , 11146632
NR3C1	PRRC2C	No	--	--	20195357
NR3C1	SRA1	No	--	--	20398657
NR3C1	CALR	No	--	--	8107808 , 8107808
NR3C1	FKBP5	Yes	--	--	20661446
NR3C1	CHD9	No	--	--	16523501
NR3C1	MED1	No	--	--	10508170 , 11266503
NR3C1	BRCC3	No	biochemical	colocalization	22863883
NR3C1	MAFF	No	--	--	20211142
NR3C1	CENPB	No	--	--	20195357 , 20195357
NR3C1	IDE	No	--	--	8051160
NR3C1	MAPK1	No	--	--	16888650 , 12351702
NR3C1	ACP1	No	--	--	20195357
NR3C1	OSGEP	No	--	--	21900206 , 21900206 , 21900206
NR3C1	TP53BP1	No	coimmunoprecipitation	--	11320256
NR3C1	PTGES3	No	--	--	9261129 , 10691735 , 10691735
NR3C1	UBE3A	No	--	--	9891052
NR3C1	LRIF1	No	--	--	17455211
NR3C1	CLIP1	No	--	--	20195357
NR3C1	RAD54L2	No	--	--	19692572
NR3C1	RARA	No	--	--	17641689
NR3C1	NR0B1	No	--	--	18160712
NR3C1	KPNA2	No	--	--	12933681
NR3C1	ZBTB16	No	--	--	14521715 , 14521715
NR3C1	HOXB1	No	--	--	12487626
NR3C1	NCOA2	No	--	association	9920895 , 12151000 , 11266503 , 9590696 , 9920895 , 12151000
NR3C1	TJP2	No	--	--	20195357
NR3C1	SMARCD1	No	--	--	12917342 , 12917342 , 12917342 , 12917342
NR3C1	CLU	No	--	--	20195357
NR3C1	SUMO2	No	--	--	21693764 , 19471022
NR3C1	NR2F2	No	--	--	14739255 , 14739255 , 14739255 , 14739255 , 14739255 , 14739255
NR3C1	RELA	No	--	--	7659084 , 10995388 , 8290595 , 10995388
NR3C1	CLTC	Yes	--	--	20195357
NR3C1	HMGB1	No	--	--	9671457
NR3C1	HMOX2	No	--	--	21900206 , 21900206 , 21900206
NR3C1	POU1F1	No	--	--	9426156 , 9426156
NR3C1	LCK	No	--	colocalization	16888650 , 16888650 , 16888650 , 16888650 , 16888650 , 16888650 , 16888650 , 16888650 , 16888650 , 16888650 , 16888650 , 16888650 , 16888650 , 16888650
NR3C1	PPP3CA	No	--	--	20195357
NR3C1	PELP1	No	--	--	12415108
NR3C1	NFKB1	No	--	--	7823959 , 16380507 , 7823959
NR3C1	ETS1	No	--	--	11279115
NR3C1	ZBTB3	No	--	--	20211142
NR3C1	HSPA1A	No	--	--	9261129 , 12093808 , 12093808
NR3C1	NR4A1	No	--	--	21900206 , 21900206 , 21900206
NR3C1	DCAF6	No	--	--	15784617 , 15784617 , 15784617 , 15784617
NR3C1	RABEP2	No	biochemical	colocalization	22863883
NR3C1	SSB	No	--	--	20195357
NR3C1	STUB1	No	--	--	11146632 , 20661446 , 23493285
NR3C1	KAT5	No	--	--	11591700
NR3C1	TMF1	No	--	--	20195357 , 20195357 , 20195357 , 20195357
NR3C1	EP300	No	--	--	17884810
NR3C1	ZBTB9	No	--	--	20211142
NR3C1	SMARCC1	No	coimmunoprecipitation	--	12917342 , 9590696 , 12917342 , 9590696
NR3C1	STAT5B	No	--	--	8878484 , 8878484 , 11158330
NR3C1	PRKDC	No	--	--	9038175 , 9038175
NR3C1	LARP7	No	biochemical	colocalization	22863883
NR3C1	STAT3	No	--	--	14522952 , 9388192 , 14522952
NR3C1	UBA52	No	--	--	11146632
NR3C1	THRAP3	No	--	--	20195357
NR3C1	SFPQ	No	--	--	19339282
NR3C1	STAT5A	No	--	--	9528750
NR3C1	PTMS	No	--	--	16150697 , 10601862 , 16150697
NR3C1	HNRNPU	No	--	--	9353307 , 9353307 , 9353307
NR3C1	RAN	No	--	--	10508170
NR3C1	FYN	No	--	--	16888650 , 16888650 , 16888650
NR3C1	SUMO4	No	--	--	16236267 , 16236267
NR3C1	UBE2I	No	--	--	11812797
NR3C1	SMARCA2	No	--	--	17043312 , 20195357 , 8223438
NR3C1	TBP	No	--	--	9649342 , 9649342
NR3C1	CD3G	No	--	--	16888650
NR3C1	MED25	No	--	--	17641689 , 17641689 , 17641689 , 17641689 , 17641689
NR3C1	PRKACA	No	--	--	11027313
NR3C1	SMAD3	No	--	--	10518526 , 10518526 , 12902338 , 12902338 , 12902338
NR3C1	CEBPB	No	--	--	9817600 , 9817600 , 9817600
NR3C1	POLR1D	No	--	--	21988832 , 21988832
NR3C1	CALM1	No	--	--	20195357 , 7887964
NR3C1	UBE2L3	No	--	--	17003263 , 17003263
NR3C1	KIAA0408	No	--	--	20195357 , 20195357
NR3C1	SRC	No	--	--	16888650 , 18160712 , 16423881
NR3C1	HSP90AA1	No	coimmunoprecipitation	colocalization	16888650 , 16888650 , 9261129 , 11751894 , 9334248 , 8898375 , 10903152 , 20195357 , 20195357 , 8089152 , 8645634 , 8621522 , 10066374 , 15916966 , 8898375 , 19875381 , 8089152 , 12093808 , 9195923 , 9195923
NR3C1	ETS2	No	--	--	11279115 , 11279115
NR3C1	IFNGR2	No	--	--	8349631
NR3C1	TCEAL2	No	--	--	20195357
NR3C1	MAGEA11	No	--	--	21730049
NR3C1	CCDC6	Yes	biochemical	colocalization	22863883
NR3C1	GNB2L1	No	--	--	15955845
NR3C1	CUL2	No	--	--	20195357
NR3C1	CWC15	No	--	--	20195357
NR3C1	AKT1	No	--	--	16888650 , 24291004 , 24291004 , 24291004 , 24291004 , 24291004
NR3C1	RANBP9	No	--	--	12361945 , 12361945
NR3C1	ZNF496	No	--	--	20211142
NR3C1	BAG1	No	--	--	9603979 , 11101523 , 9603979 , 23493285