Gene Report

Basic Info

Approved Symbol	SDC2
Previous Symbol	"HSPG\|HSPG1"
Symbol Alias	"fibroglycan\|SYND2\|CD362"
Approved Name	syndecan 2
Previous Name	heparan sulfate proteoglycan 1, cell surface-associated
Name Alias	syndecan proteoglycan 2
Location	8q22-q23
Position	chr8:96493351-96611780, 1
External Links	HGNC: 10659 Entrez Gene: 6383 Ensembl: ENSG00000169439 UCSC: uc003yhv.1
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Ashley-Koch, A. E.,2015	Current PTSD	rs2437772	Trend

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Ashley-Koch, A. E.,2015	Current PTSD	Childhood trauma	rs2437772	Non-significant

Gene functional annotation

Gene related GO terms (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0043025	neuronal cell body	cellular component	IEA	18
GO:0006027	glycosaminoglycan catabolic process	biological process	TAS	1
GO:0016477	cell migration	biological process	IBA	6
GO:0030204	chondroitin sulfate metabolic process	biological process	TAS	2
GO:0048813	dendrite morphogenesis	biological process	IBA	1
GO:0007411	axon guidance	biological process	TAS	16
GO:0031000	response to caffeine	biological process	IEA	1
GO:0016021	integral component of membrane	cellular component	IEA	56
GO:0001666	response to hypoxia	biological process	IEA	13
GO:0030165	PDZ domain binding	molecular function	IPI[18256285]	4
GO:0008150	biological_process	biological process	ND	11
GO:0042060	wound healing	biological process	IEA	3
GO:0005796	Golgi lumen	cellular component	TAS	1
GO:0030198	extracellular matrix organization	biological process	TAS	8
GO:0005515	protein binding	molecular function	IPI[9660868\|11356864\|22660413]	169
GO:0043202	lysosomal lumen	cellular component	TAS	2
GO:0048013	ephrin receptor signaling pathway	biological process	TAS	3
GO:0009986	cell surface	cellular component	IBA	21
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0007603	phototransduction, visible light	biological process	TAS	7
GO:0006775	fat-soluble vitamin metabolic process	biological process	TAS	6
GO:0030203	glycosaminoglycan metabolic process	biological process	TAS	2
GO:0008218	bioluminescence	biological process	IEA	1
GO:0005975	carbohydrate metabolic process	biological process	TAS	3
GO:0006766	vitamin metabolic process	biological process	TAS	7
GO:0001523	retinoid metabolic process	biological process	TAS	6
GO:0048814	regulation of dendrite morphogenesis	biological process	ISS	3
GO:0045202	synapse	cellular component	IEA	7
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0006024	glycosaminoglycan biosynthetic process	biological process	TAS	2

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in PTSDgene
hsa04514	Cell adhesion molecules (CAMs)	7
hsa04512	ECM-receptor interaction	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 9)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
SDC2	BAG6	No	--	--	21988832 , 21988832
SDC2	TRAPPC4	No	--	--	11018053
SDC2	ITPR1	No	--	--	12676536
SDC2	REG3A	No	--	--	8997243 , 8997243
SDC2	TGFBR3	No	--	--	14976204
SDC2	EPB41L1	No	--	--	12676536
SDC2	ELAVL1	No	--	--	19322201
SDC2	LAMA3	No	--	--	11373281 , 11373281 , 11373281
SDC2	PPP3CC	No	--	--	21988832 , 21988832