Study Report
Study Information
Basic Info
| Reference |
Amstadter, A. B.,2009 PMID: 19162436
|
| Citation |
Amstadter, A. B., et al. (2009). "Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure." J Anxiety Disord 23(3): 369-373. |
| Phenotype |
Post-hurricane PTSD symptoms, Lifetime PTSD symptoms |
| Trauma |
2004 Florida hurricane |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study, Gene-environment interaction study |
| Sample Size |
607 participants in the 2004 Florida Hurricanes Study |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
90% European-American (EA), 3.9% African-American (AA), 3.9% Hispanic, 1.7% other, 0.5% missing self-report race/ethnicity data. |
| Gender |
35.1% male and 64.9% female |
| Age |
22.6% <=59 years old, 77.4% >=60 years old. |
Detail Info
| Sample Diagnosis |
NWS PTSD module |
| Related Diagnostic Tools |
Assessments were conducted via highly structured interview using computer-assisted telephone interview (CATI) methodology. PTSD was assessed with the National Women's Study (NWS) PTSD module. |
| Sample Status |
A probability sample of adults from telephone households in 38 counties in Florida within 6-9 months of the 2004 hurricane season, between April 5 and June 12, 2005 completed telephone interviews. Sample selection and telephone interviewing via random-digit-dial procedures were performed by an experienced research firm. Hurricane exposure was assessed with indicators identified in previous research (Freedy, Saladin, Kilpatrick, Resnick, & Saunders,1994) on the basis of relation to posthurricane psychological functioning (more details please see the articles). PTE exposure was measured using behaviorally speci?c language that asked if participants had been exposed to ?ve types of events and during this exposure feared that they would be killed or seriously injured. Social support during the 6 months prior to the hurricanes was measured via a modi?ed version of the Medical Outcomes Study module (Sherbourne & Stewart, 1991) that assesses emotional,instrumental, and appraisal social support with ?ve items. |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
Rs4606 was associated with increased symptoms of posthurricane PTSD symptoms under conditions of high hurricane exposure and low social support (P-value<.05). Further, this polymorphism was associated with lifetime PTSD symptoms under conditions of lifetime exposure to a potentially traumatic event, and low social support (P-value<.001). These gene by environment interactions remained significant after adjustment for sex, ancestry, and age. RGS2 rs4606 modifies risk of postdisaster and lifetime PTSD symptoms under conditions of high stressor exposure. This is the first demonstration of gene-environment interaction for this locus. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs4606
|
Lifetime PTSD symptoms |
RGS2 |
Genotype: with lifetime PTSD symptoms, B=0.02, t=0.08, P-value=0.93. |
No significant signals was observed about this SNP with life......
No significant signals was observed about this SNP with lifetime PTSD symptoms.
More...
|
Non-significant |
|
rs4606
|
Post-hurricane PTSD symptoms |
RGS2 |
Genotype: with posthurricane PTSD symptoms, B=0.02, t=0.13, P-value=0.89. |
No significant signals was observed about this SNP with post......
No significant signals was observed about this SNP with posthurricane PTSD symptoms.
More...
|
Non-significant |
Gene * Environment result reported by this study (count: 2)
| Marker |
Phenotype |
Related Gene |
Environment |
Statistical Values |
Author Comments |
Marker's Category |
|
rs4606
|
Lifetime PTSD symptoms |
RGS2 |
PTE/hurricane exposure, Social support |
Three-way interaction (genotype by hurricane exposure by social support), lifetime PTSD symptoms: B= 1.12, t=3.71, P-value< .001. |
Neither of the two-way interactions (genotype by hurricane e......
Neither of the two-way interactions (genotype by hurricane exposure and genotype by social support) was a significant predictor of posthurricane or lifetime PTSD symptoms. The three-way interaction (genotype by hurricane exposure by social support),however, was significantly predictive in both models. The same pattern of results was found when conducting these analyses with the sample restricted to Caucasian participants, and when controlling for the effects of the 5HTTLPR genotype.
More...
|
Significant |
|
rs4606
|
Post-hurricane PTSD symptoms |
RGS2 |
PTE/hurricane exposure, Social support |
Three-way interaction (genotype by hurricane exposure by social support), posthurricane PTSD symptoms: B=.58, t=2.18, P-value=.029. |
Neither of the two-way interactions (genotype by hurricane e......
Neither of the two-way interactions (genotype by hurricane exposure and genotype by social support) was a significant predictor of posthurricane or lifetime PTSD symptoms. The three-way interaction (genotype by hurricane exposure by social support),however, was significantly predictive in both models. The same pattern of results was found when conducting these analyses with the sample restricted to Caucasian participants, and when controlling for the effects of the 5HTTLPR genotype.
More...
|
Significant |
