Gene Report

Basic Info

Approved Symbol	TLL1
Approved Name	tolloid like 1
Location	4q32.3
Position	chr4:165873258-166103895, 1
External Links	HGNC: 11843 Entrez Gene: 7092 Ensembl: ENSG00000038295 UCSC: uc003irh.2
No. of Association Results	4 (Positive: 2; Negative: 2; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 4)

Reference	Phenotype	Marker	Gene's Category
Ashley-Koch, A. E.,2015	Current PTSD	rs6812849	Non-significant
Xie, P.,2013	Lifetime PTSD	rs1503292 ; rs6812849 ; rs7691872	Significant
Nievergelt, C. M.,2015	PTSD	rs113712660	Significant
Almli, L. M.,2014	PTSD symptoms (mPSS)	rs1503292 ; rs6812849 ; rs7691872	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs113712660 ; rs1503292 ; rs6812849 ; rs7691872	Non-significant

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0006508	proteolysis	biological process	IEA	5
GO:0001501	skeletal system development	biological process	TAS[8661043]	3
GO:0005576	extracellular region	cellular component	TAS	31
GO:0005518	collagen binding	molecular function	IEA	1
GO:0005509	calcium ion binding	molecular function	IEA	9
GO:0030198	extracellular matrix organization	biological process	TAS	8
GO:0022617	extracellular matrix disassembly	biological process	TAS	2
GO:0030154	cell differentiation	biological process	IEA	10
GO:0008270	zinc ion binding	molecular function	IEA	26
GO:0004222	metalloendopeptidase activity	molecular function	IEA	1

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 3)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
TLL1	UBC	No	--	--	21963094
TLL1	APP	No	--	--	21832049
TLL1	CHRD	No	--	--	10479448