PTSDgene database

SNP Report

Basic Info
Name rs115028822 dbSNP Ensembl
Location 6:158141992 - 158141992(+)
Variant Seq A
Ancestral Allele C
Ref Seq C
Minor Allele Frequence 0.0377396
Annotation downstream_gene_variant; intron_variant; NMD_transcript_variant
Variant Effect downstream_gene_variant(ENST00000607000); intron_variant(ENST00000607071, ENST00000606965, ENST00000367101, ENST00000607742, ENST00000367104); NMD_transcript_variant(ENST00000607071, ENST00000606965, ENST00000607742)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000367104, ENST00000606965, ENST00000607000, ENST00000367101)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000367104, ENST00000606965, ENST00000607000, ENST00000367101)
rSNP? Yes Link in rVarBase
Related Regulatory Elements Chromatin interactive region
Chromatin State Weak transcription;Strong transcription
No. of Marker's Association Results 1 (Positive: 0; Negative: 0; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Nievergelt, C. M.,2015 PTSD In meta-analysis: P-value=1.6E-06. In meta-analysis: P-value=1.6E-06. It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More... Trend
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Nievergelt, C. M.,2015 PTSD Childhood trauma Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More... It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
SERAC1 serine active site containing 1 6q25.3 1(0/0/1)

SNPs in LD with rs115028822 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx