Gene Report

Basic Info

Approved Symbol	PRKG1
Previous Symbol	"PRKGR1B\|PRKG1B"
Symbol Alias	"PGK\|PKG"
Approved Name	protein kinase, cGMP-dependent, type I
Location	10q11.2
Position	chr10:50991358-52298350, 1
External Links	HGNC: 9414 Entrez Gene: 5592 Ensembl: ENSG00000185532 UCSC: uc001jjm.3
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Ashley-Koch, A. E.,2015	Current PTSD	rs10762479	Trend

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Ashley-Koch, A. E.,2015	Current PTSD	Childhood trauma	rs10762479	Non-significant

Gene functional annotation

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007596	blood coagulation	biological process	TAS	11
GO:0005737	cytoplasm	cellular component	IDA[21402151]	109
GO:0098779	mitophagy in response to mitochondrial depolarization	biological process	IGI[22020285]	1
GO:0030036	actin cytoskeleton organization	biological process	TAS[10851246]	3
GO:0005794	Golgi apparatus	cellular component	IEA	17
GO:0060087	relaxation of vascular smooth muscle	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[14608379\|16990611\|19424179\|21402151\|25416956]	169
GO:0016358	dendrite development	biological process	IEA	3
GO:0030900	forebrain development	biological process	IEA	1
GO:0030553	cGMP binding	molecular function	IEA	1
GO:0090331	negative regulation of platelet aggregation	biological process	IMP[16990611]	2
GO:0004692	cGMP-dependent protein kinase activity	molecular function	IDA[21402151]	1
GO:0001764	neuron migration	biological process	IEA	3
GO:0043087	regulation of GTPase activity	biological process	IMP[14608379]	2
GO:0005524	ATP binding	molecular function	IEA	23
GO:0005829	cytosol	cellular component	TAS	78
GO:0005246	calcium channel regulator activity	molecular function	IDA[21402151]	4
GO:0019934	cGMP-mediated signaling	biological process	IEA	2
GO:0005886	plasma membrane	cellular component	IDA[16990611\|21402151]	99
GO:0006468	protein phosphorylation	biological process	IEA	7
GO:0007165	signal transduction	biological process	TAS[2792381]	34

Gene related KEGG pathways (count: 3)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 9)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
PRKG1	ITPR1	No	--	--	18757735 , 8132598 , 18757735 , 12480535 , 10724174 , 10724174 , 10724174
PRKG1	GKAP1	No	--	--	10671526
PRKG1	HECW2	No	--	--	24163370
PRKG1	FHOD1	No	--	--	15051728
PRKG1	LASP1	No	--	--	12571245
PRKG1	SF1	No	--	--	10449420
PRKG1	MRVI1	No	--	--	12480535 , 11309393 , 10724174 , 11309393 , 10724174 , 10724174 , 10724174 , 10724174
PRKG1	SEPT3	No	--	--	15107017
PRKG1	TRIM39	No	--	--	17601797