Gene Report

Basic Info

Approved Symbol	KDM7A
Previous Symbol	JHDM1D
Symbol Alias	KIAA1718
Approved Name	lysine (K)-specific demethylase 7A
Previous Name	jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
Location	7q34
Position	chr7:140084746-140177035, -1
External Links	HGNC: 22224 Entrez Gene: 80853 Ensembl: ENSG00000006459
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	rs79485117	Trend

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs79485117	Significant

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0032454	histone demethylase activity (H3-K9 specific)	molecular function	IDA[20023638\|20194436\|20622853]	1
GO:0033169	histone H3-K9 demethylation	biological process	IDA[20023638\|20194436\|20622853]	1
GO:0071558	histone demethylase activity (H3-K27 specific)	molecular function	IDA[20023638\|20194436\|20622853]	1
GO:0030901	midbrain development	biological process	ISS	2
GO:0006325	chromatin organization	biological process	TAS	6
GO:0005730	nucleolus	cellular component	IDA	9
GO:0005506	iron ion binding	molecular function	IDA[20023638]; TAS[20194436]	5
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	molecular function	IDA[20023638\|20194436]	1
GO:0051864	histone demethylase activity (H3-K36 specific)	molecular function	IDA[20622853]	1
GO:0070544	histone H3-K36 demethylation	biological process	IDA[20622853]	1
GO:0005634	nucleus	cellular component	IC[20023638]	81
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IEA	11
GO:0071557	histone H3-K27 demethylation	biological process	IDA[20023638\|20194436\|20622853]	1
GO:0008270	zinc ion binding	molecular function	IDA[20023638]	26
GO:0055114	oxidation-reduction process	biological process	IEA	18
GO:0005654	nucleoplasm	cellular component	IDA; TAS	43
GO:0035575	histone demethylase activity (H4-K20 specific)	molecular function	IDA[20622853]	1
GO:0035064	methylated histone binding	molecular function	IDA[20023638]	2
GO:0035574	histone H4-K20 demethylation	biological process	IDA[20622853]	1
GO:0006351	transcription, DNA-templated	biological process	IEA	21

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 0)