SNP Report
Basic Info
| Name | rs12944712 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 17:45793781 - 45793781(+) | ||
| Variant Seq | A | ||
| Ancestral Allele | G | ||
| Ref Seq | G | ||
| Minor Allele Frequence | 0.271765 | ||
| Annotation | intron_variant; NMD_transcript_variant; non_coding_transcript_variant | ||
| Variant Effect | intron_variant(ENST00000352855, ENST00000347197, ENST00000577353, ENST00000634540, ENST00000619154, ENST00000398285, ENST00000587305, ENST00000314537, ENST00000339069, ENST00000582766, ENST00000293493); NMD_transcript_variant(ENST00000347197); non_coding_transcript_variant(ENST00000587305, ENST00000582766) | ||
| SIFT Annotation | tolerated_-_low_confidence; deleterious_-_low_confidence | ||
| SIFT Variant Effect | tolerated_-_low_confidence(ENST00000314537, ENST00000398285, ENST00000577353, ENST00000293493); deleterious_-_low_confidence(ENST00000619154, ENST00000347197, ENST00000352855) | ||
| PolyPhen Annotation | unknown; benign; possibly_damaging | ||
| PolyPhen Variant Effect | unknown(ENST00000619154); benign(ENST00000347197, ENST00000398285, ENST00000352855, ENST00000577353, ENST00000293493); possibly_damaging(ENST00000314537) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | Chromatin interactive region | ||
| Chromatin State | Enhancers;Weak transcription;Bivalent Enhancer | ||
| No. of Marker's Association Results | 5 (Positive: 3; Negative: 2; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Amstadter, A. B.,2011 | Acute symptoms of PTSD | Latent growth analyses, z-statistic=3.35, P-value<0.001. Latent growth analyses, z-statistic=3.35, P-value<0.001. | Having an increasing number of G alleles was significantly a...... Having an increasing number of G alleles was significantly associated with more acute symptoms of PTSD. More... | Significant |
| Amstadter, A. B.,2011 | Acute UCLA PTSD-RI score | B=-5.36, t=-2.94, Empirical P-value=0.005 B=-5.36, t=-2.94, Empirical P-value=0.005 | This SNP was significantly related to PTSD symptom frequency...... This SNP was significantly related to PTSD symptom frequency. With Bonferroni correction, one of the eight SNPs (rs12944712) remained significantly associated with PTSD symptom frequency. More... | Significant |
| Amstadter, A. B.,2011 | Decline in PTSD symptoms | Latent growth analyses, z-statistic=-3.74, P-value<0.001. Latent growth analyses, z-statistic=-3.74, P-value<0.001. | An increasing number of G alleles was associated with a sign...... An increasing number of G alleles was associated with a significantly greater decline in PTSD symptoms over time. More... | Significant |
| Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | T4: joint test P-value> 0.05, variant P-value> 0.05. T4: joint test P-value> 0.05, variant P-value> 0.05. | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More... | Non-significant |
| Dunn, E. C.,2014 | Post-traumatic stress symptoms (PTS) | T4: joint test P-value> 0.05, variant P-value> 0.05. T4: joint test P-value> 0.05, variant P-value> 0.05. | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTS (P-values > 0.05). More... | Non-significant |
G*E study related association result (count: 2)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | Hurricane exposure | T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More... | Non-significant |
| Dunn, E. C.,2014 | Post-traumatic stress symptoms (PTS) | Hurricane exposure | Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More... | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More... | Non-significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CRHR1 | corticotropin releasing hormone receptor 1 | 17q21.31 | 12(6/6/0) |
SNPs in LD with rs12944712 (count: 4)
Literature-origin SNPs (count: 0)
LD-proxies (count: 4)
SNP related eQTL (count: 1)