Study Report

Study Information

Basic Info

Reference	Nievergelt, C. M.,2015 PMID: 25456346
Citation	Nievergelt, C. M., et al. (2015). "Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene." Psychoneuroendocrinology 51: 459-471.
Phenotype	PTSD
Trauma	Combat
Study Design	Case-control
Study Type	Genome-wide association study, Gene-environment interaction study
Sample Size	940 PTSD and 2554 controls
SNP/Marker Size	888,113 SNPs
Predominant Ethnicity	Caucasian, Black
Population	European, African, Hispanic/Native American, and other descent
Gender	All male
Age	Cases: mean age=23.0 years, SD=3.0, range from 18 to 38. Control: mean age=23.2 years, SD=3.5, range from 18 to 48.

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	The Clinician Administered PTSD Scale (CAPS), a modified version of the Childhood Trauma Questionnaire Short Form (CTQ), Life Events Checklist (LEC).
Sample Status	Subjects with partial and/or full PTSD diagnosis were called cases, all other subjects were designated controls. Samples are from combat-exposed U.S. Marines and Sailors from the Marine Resiliency Study (MRS) scheduled for deployment to Iraq and/or Afghanistan.
Controls Exposed	Yes
Replication Size	491 Veterans Affairs (VA) samples from previous study.
Result Summary	Results: The array produced >800 K directly genotyped and >21 M imputed markers in 3494 unrelated, trauma-exposed males, of which 940 were diagnosed with partial or full PTSD. The GWAS meta-analysis identified the phosphoribosyl transferase domain containing 1 gene (PRTFDC1) as a genome-wide significant PTSD locus (rs6482463; OR=1.47, SE=0.06, P-value=2.04E-09), with a similar effect across ancestry groups. Association of PRTFDC1 with PTSD in an independent military cohort showed some evidence for replication. Loci with suggestive evidence of association (n=25 genes, P-value< 5E-06) further implicated genes related to immune response and the ubiquitin system, but these findings remain to be replicated in larger GWASs. A replication analysis of 25 putative PTSD genes from the literature found nominally significant SNPs for the majority of these genes, but associations did not remain significant after correction for multiple comparison. A cross-disorder analysis of polygenic risk scores from GWASs of BPD, MDD, and SCZ found that PTSD diagnosis was associated with risk sores of BPD, but not with MDD or SCZ. Conclusions: This first multi-ethnic/racial GWAS of PTSD highlights the potential to increase power through meta-analyses across ancestry groups. We found evidence for PRTFDC1 as a potential novel PTSD gene, a finding that awaits further replication. Our findings indicate that the genetic architecture of PTSD may be determined by many SNPs with small effects, and overlap with other neuropsychiatric disorders, consistent with current findings from large GWAS of other psychiatric disorders.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 53)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs6482463	PTSD	PRTFDC1	Additive model: in EA (European American) sample: OR=1.41, SE=0.08, P-value=2.98E-05; in AA (African American) sample: OR=1.49, SE=0.26, P-value=0.118; in HNA (Hispanic and Native American descent) sample: OR=1.58, SE=0.14, P-value=1.25E-03; in OTH (other) sample: OR=1.55, SE=0.18, P-value=0.012; meta-analysis in four Marine Resiliency Study(MRS) groups: OR=1.47, SE=0.06, P-value=2.04E-09, P-value=0.90 for Cochran's Q. Recessive genetic models: P-value=2.03E-03, dominant genetic models: P-value=3.2E-09. Cumulative model including SNP, age, LEC, CTQ and prior deployment (plus the standard covariates battalion, GWAS platform, and 5 PC's for ancestry) in predicting PTSD status P-value=4.07E-94 and explained about 20% of the variance.	We found evidence for PRTFDC1 as a potential novel PTSD gene...... We found evidence for PRTFDC1 as a potential novel PTSD gene. More...	Significant
rs6528940	PTSD	MAGEC1	In subjects of European: P-value=1.3E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs6314	PTSD	HTR2A	In 2179 MRS subjects of European descent: P-value=0.049.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs6759539	PTSD	LINC01090	In 2179 MRS subjects of European descent: P-value=0.002.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs6681010	PTSD	FASLG	In meta-analysis: P-value=2.0E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs73220799	PTSD	PLXNC1	In subjects of European: P-value=4.3E-06. In meta-analysis: P-value=4.4E-07.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs6968349	PTSD	ADCYAP1R1	In 2179 MRS subjects of European descent: P-value=0.017.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs77929608	PTSD	SRD5A2	In 2179 MRS subjects of European descent: P-value=0.049.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs75924850	PTSD	DRD2	In 2179 MRS subjects of European descent: P-value=0.021.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs74939664	PTSD	ADGRL2	In subjects of European: P-value=2.0E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs1033962	PTSD	PRTFDC1	Additive model: in EA (European American) sample: OR=1.40, SE=0.08, P-value=4.48E-05; in AA (African American) sample: OR=1.45, SE=0.25, P-value=0.148; in HNA (Hispanic and Native American descent) sample: OR=1.57, SE=0.14, P-value=1.37E-03; in OTH (other) sample: OR=1.52, SE=0.17, P-value=0.016; meta-analysis in four Marine Resiliency Study(MRS) groups: OR=1.45, SE=0.06, P-value=4.93E-09, P-value=0.90 for Cochran's Q; in an independent replication sample from the National Center for PTSD/Boston (NCPTS): OR=1.28, SE=0.17, P-value=0.144, P-value=0.90 for Cochran's Q; meta-analysis in MRS groups and NCPTS: OR=1.43, SE=0.06, P-value=2.06E-09, P-value=0.91 for Cochran's Q.	We found evidence for PRTFDC1 as a potential novel PTSD gene...... We found evidence for PRTFDC1 as a potential novel PTSD gene. More...	Significant
rs10457838	PTSD	UST	In subjects of African: P-value=2.2E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs363238	PTSD	SLC18A2	In 2179 MRS subjects of European descent: P-value=0.022.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs28914827	PTSD	SLC6A4	In 2179 MRS subjects of European descent: P-value=0.14.	No significant result. No significant result.	Non-significant
rs3100127	PTSD	LGR6	In subjects of African: P-value=1.3E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs10511822	PTSD	LINGO2	In subjects of European: P-value=3.1E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs4511180	PTSD	PTPRVP	In subjects of African: P-value=7.7E-07.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs4916008	PTSD	JAK1	In subjects of European: P-value=4.0E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs4838092	PTSD	LHX2	In subjects of African: P-value=9.0E-07.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs4659395	PTSD	STMN1	In 2179 MRS subjects of European descent: P-value=0.09.	No significant result. No significant result.	Non-significant
rs62275374	PTSD	LRPAP1	In subjects of European: P-value=4.5E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs518425	PTSD	CHRNA5	In 2179 MRS subjects of European descent: P-value=0.07.	No significant result. No significant result.	Non-significant
rs4987059	PTSD	DRD4	In 2179 MRS subjects of European descent: P-value=0.10.	No significant result. No significant result.	Non-significant
rs544437	PTSD	TPH1	In 2179 MRS subjects of European descent: P-value=0.25.	No significant result. No significant result.	Non-significant
rs139604943	PTSD	ANK3	In 2179 MRS subjects of European descent: P-value=0.008.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs141129523	PTSD	RGS2	In 2179 MRS subjects of European descent: P-value=0.022.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs1380630	PTSD	LOC729307	In meta-analysis: P-value=1.9E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs138384996	PTSD	UBE2U	In meta-analysis: P-value=4.1E-07.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs12442490	PTSD	RORA	In 2179 MRS subjects of European descent: P-value=0.003.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs116897693	PTSD	CRHR1	In 2179 MRS subjects of European descent: P-value=0.023.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs116647843	PTSD	DTNBP1	In 2179 MRS subjects of European descent: P-value=0.06.	No significant result. No significant result.	Non-significant
rs115028822	PTSD	SERAC1	In meta-analysis: P-value=1.6E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs113712660	PTSD	TLL1	In 2179 MRS subjects of European descent: P-value=0.017.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs1081105	PTSD	APOE	In 2179 MRS subjects of European descent: P-value=0.05.	P-value is suggestive significant (P-value=0.05). P-value is suggestive significant (P-value=0.05).	Non-significant
rs10737854	PTSD	RGS7	In subjects of European: P-value=4.6E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs78826942	PTSD	FRMD5	In meta-analysis: P-value=3.8E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs2616978	PTSD	CSMD1	In subjects of Hispanic/Native American (HNA): P-value=2.8E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs79485117	PTSD	KDM7A	In meta-analysis: P-value=4.4E-07.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs79590198	PTSD	NR3C1	In 2179 MRS subjects of European descent: P-value=0.09.	No significant result. No significant result.	Non-significant
rs2471320	PTSD	JHDM1D-AS1	In meta-analysis: P-value=4.2E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs2312236	PTSD	POGK	In subjects of Hispanic/Native American (HNA): P-value=2.9E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs9366890	PTSD	FKBP5	In 2179 MRS subjects of European descent: P-value=0.015.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs187093517	PTSD	UBE2E3	In subjects of European: P-value= 2.8E-07.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs199563271	PTSD	PTPRT	In subjects of European: P-value=1.4E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs2148269	PTSD	PRTFDC1	In subjects of European: P-value=4.6E-06. In meta-analysis: P-value=8.0E-07.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs9545302	PTSD	LINC01080	In subjects of European: P-value=1.4E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs183063707	PTSD	TPH2	In 2179 MRS subjects of European descent: P-value=0.017.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs17551315	PTSD	WWC1	In 2179 MRS subjects of European descent: P-value=0.001.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs174686	PTSD	COMT	In 2179 MRS subjects of European descent: P-value=0.049.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs148952004	PTSD	PPM1N	In subjects of European: P-value=3.8E-06. In meta-analysis: P-value=1.8E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend
rs148139959	PTSD	GABRA2	In 2179 MRS subjects of European descent: P-value=0.024.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs144782362	PTSD	SLC6A3	In 2179 MRS subjects of European descent: P-value=0.008.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant
rs142570922	PTSD	CYP11B1	In meta-analysis: P-value=3.8E-06.	It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More...	Trend

Gene * Environment result reported by this study (count: 52)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs10511822	PTSD	LINGO2	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs10737854	PTSD	RGS7	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs1081105	PTSD	APOE	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value=0.036.	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant
rs113712660	PTSD	TLL1	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs115028822	PTSD	SERAC1	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs116647843	PTSD	DTNBP1	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs116897693	PTSD	CRHR1	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs12442490	PTSD	RORA	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs10457838	PTSD	UST	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs174686	PTSD	COMT	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs148952004	PTSD	PPM1N	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs148139959	PTSD	GABRA2	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs199563271	PTSD	PTPRT	Childhood trauma	In subjects of African, gene and childhood trauma interaction: P-value=0.020.	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant
rs187093517	PTSD	UBE2E3	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs183063707	PTSD	TPH2	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs17551315	PTSD	WWC1	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs138384996	PTSD	UBE2U	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs1380630	PTSD	LOC729307	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs144782362	PTSD	SLC6A3	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs142570922	PTSD	CYP11B1	Childhood trauma	In subjects of Hispanic/Native American, gene and childhood trauma interaction: P-value=0.036. In other descents, gene and childhood trauma interaction: P-value=0.027.	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant
rs141129523	PTSD	RGS2	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs139604943	PTSD	ANK3	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs4838092	PTSD	LHX2	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs4511180	PTSD	PTPRVP	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs4659395	PTSD	STMN1	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs518425	PTSD	CHRNA5	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs544437	PTSD	TPH1	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs4916008	PTSD	JAK1	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs4987059	PTSD	DRD4	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs2471320	PTSD	JHDM1D-AS1	Childhood trauma	In subjects of African, gene and childhood trauma interaction: P-value=0.003.	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant
rs2148269	PTSD	PRTFDC1	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs2312236	PTSD	POGK	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs3100127	PTSD	LGR6	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs363238	PTSD	SLC18A2	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs2616978	PTSD	CSMD1	Childhood trauma	In subjects of African, gene and childhood trauma interaction: P-value=0.050.	It showed a suggestive interaction effect with childhood tra...... It showed a suggestive interaction effect with childhood trauma on PTSD. More...	Non-significant
rs28914827	PTSD	SLC6A4	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs74939664	PTSD	ADGRL2	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs75924850	PTSD	DRD2	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs6968349	PTSD	ADCYAP1R1	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs6759539	PTSD	LINC01090	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs73220799	PTSD	PLXNC1	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs6482463	PTSD	PRTFDC1	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs6314	PTSD	HTR2A	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs6681010	PTSD	FASLG	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs6528940	PTSD	MAGEC1	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs62275374	PTSD	LRPAP1	Childhood trauma	In subjects of European, gene and childhood trauma interaction: P-value=0.006.	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant
rs9545302	PTSD	LINC01080	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs9366890	PTSD	FKBP5	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs77929608	PTSD	SRD5A2	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs78826942	PTSD	FRMD5	Childhood trauma	Gene and childhood trauma interaction: P-value<0.05 in any subjects.	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant
rs79485117	PTSD	KDM7A	Childhood trauma	In subjects of African, gene and childhood trauma interaction: P-value=0.027.	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant
rs79590198	PTSD	NR3C1	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value=0.022.	It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More...	Significant