Gene Report

Basic Info

Approved Symbol	HTR2A
Previous Symbol	HTR2
Symbol Alias	5-HT2A
Approved Name	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Previous Name	5-hydroxytryptamine (serotonin) receptor 2A
Location	13q14-q21
Position	chr13:46831550-46897076, -1
External Links	HGNC: 5293 Entrez Gene: 3356 Ensembl: ENSG00000102468 UCSC: uc010acr.4
No. of Association Results	4 (Positive: 2; Negative: 2; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 4)

Reference	Phenotype	Marker	Gene's Category
Mellman, T. A.,2009	PTSD	rs6311	Significant
Nievergelt, C. M.,2015	PTSD	rs6314	Significant
Solovieff, N.,2014	PTSD diagnosis	rs10507545	Non-significant
Solovieff, N.,2014	PTSD severity	rs9534507	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs6314	Non-significant

Gene functional annotation

Gene related GO terms (count: 49)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0032403	protein complex binding	molecular function	IEA	8
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IDA[19057895]	10
GO:0007202	activation of phospholipase C activity	biological process	IDA[16517693]	4
GO:0043406	positive regulation of MAP kinase activity	biological process	IEA	2
GO:0051209	release of sequestered calcium ion into cytosol	biological process	IDA[15862800]; IMP[18703043]	3
GO:0005829	cytosol	cellular component	IEA	78
GO:0007613	memory	biological process	IEA	11
GO:0045821	positive regulation of glycolytic process	biological process	IEA	1
GO:0016023	cytoplasmic, membrane-bounded vesicle	cellular component	IEA	6
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IEA	4
GO:0045600	positive regulation of fat cell differentiation	biological process	IEA	2
GO:0014059	regulation of dopamine secretion	biological process	IEA	6
GO:0043198	dendritic shaft	cellular component	IEA	3
GO:0070852	cell body fiber	cellular component	IEA	4
GO:0001659	temperature homeostasis	biological process	IEA	2
GO:0042493	response to drug	biological process	IDA[15862800\|18703043]	25
GO:0001618	virus receptor activity	molecular function	IEA	3
GO:0004993	G-protein coupled serotonin receptor activity	molecular function	IDA[7582481\|15862800]	2
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	biological process	IEA	3
GO:0007568	aging	biological process	IEA	11
GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	biological process	IEA	1
GO:0001965	G-protein alpha-subunit binding	molecular function	IEA	3
GO:0014065	phosphatidylinositol 3-kinase signaling	biological process	IDA[16517693]	2
GO:0006874	cellular calcium ion homeostasis	biological process	IDA[16517693\|19057895]	9
GO:0051967	negative regulation of synaptic transmission, glutamatergic	biological process	IEA	2
GO:0043025	neuronal cell body	cellular component	IEA	18
GO:0030431	sleep	biological process	IEA	3
GO:0008284	positive regulation of cell proliferation	biological process	IEA	14
GO:0008219	cell death	biological process	IEA	1
GO:0050965	detection of temperature stimulus involved in sensory perception of pain	biological process	IEA	1
GO:0005887	integral component of plasma membrane	cellular component	IEA	36
GO:0046883	regulation of hormone secretion	biological process	IEA	2
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	biological process	IDA[19057895]	1
GO:0014824	artery smooth muscle contraction	biological process	IEA	1
GO:0050795	regulation of behavior	biological process	IEA	2
GO:0044380	protein localization to cytoskeleton	biological process	IEA	1
GO:0030424	axon	cellular component	IEA	16
GO:0007210	serotonin receptor signaling pathway	biological process	IMP[18703043]	2
GO:0005886	plasma membrane	cellular component	IDA[15862800\|18703043]; TAS	99
GO:0045907	positive regulation of vasoconstriction	biological process	IEA	3
GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	molecular function	IDA[19057895]	1
GO:0007268	synaptic transmission	biological process	TAS[9109547]	32
GO:0014832	urinary bladder smooth muscle contraction	biological process	IEA	1
GO:0051378	serotonin binding	molecular function	IDA[7582481\|15831837\|15862800\|19057895]	2
GO:0043267	negative regulation of potassium ion transport	biological process	IEA	4
GO:0005901	caveola	cellular component	IEA	7
GO:0048148	behavioral response to cocaine	biological process	IEA	5
GO:0008144	drug binding	molecular function	IDA[15831837\|15862800\|18703043]	13
GO:0046718	viral entry into host cell	biological process	IEA	4

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in PTSDgene
hsa04020	Calcium signaling pathway	11
hsa04540	Gap junction	6
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 12)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
HTR2A	MRPL28	No	--	--	16537434
HTR2A	NTRK3	No	--	--	16537434
HTR2A	ANKS1B	No	--	--	16537434
HTR2A	GNAI1	No	--	--	11916537
HTR2A	PON2	No	--	--	16537434
HTR2A	GNAQ	No	--	--	11916537
HTR2A	GNA11	No	--	--	11916537
HTR2A	NME3	No	--	--	16537434
HTR2A	DLG4	No	--	--	12682061 , 12682061
HTR2A	MAP1A	No	--	--	16537434
HTR2A	RPS6KA3	No	--	--	16537434
HTR2A	PPP5C	No	--	--	16537434