PTSDgene database

SNP Report

Basic Info
Name rs4606 dbSNP Ensembl
Location 1:192812042 - 192812042(+)
Variant Seq G,T
Ancestral Allele G
Ref Seq C
Minor Allele Frequence 0.348842
Annotation downstream_gene_variant; 3_prime_UTR_variant
Variant Effect downstream_gene_variant(ENST00000487236, ENST00000464302, ENST00000483295); 3_prime_UTR_variant(ENST00000235382)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000235382)
PolyPhen Annotation probably_damaging
PolyPhen Variant Effect probably_damaging(ENST00000235382)
rSNP? No Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Inactive region
No. of Marker's Association Results 4 (Positive: 1; Negative: 3; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 4)
Reference Phenotype Statistical Values Author Comments Marker's Category
Amstadter, A. B.,2009 Lifetime PTSD symptoms Genotype: with lifetime PTSD symptoms, B=0.02, t=0.08, P-va...... Genotype: with lifetime PTSD symptoms, B=0.02, t=0.08, P-value=0.93. More... No significant signals was observed about this SNP with life...... No significant signals was observed about this SNP with lifetime PTSD symptoms. More... Non-significant
Dunn, E. C.,2014 Post Traumatic Growth (PTG) T4: joint test P-value=0.0044, variant P-value=0.071. T4: joint test P-value=0.0044, variant P-value=0.071. We found a significant association between RGS2 and PTG, whi...... We found a significant association between RGS2 and PTG, which was mainly driven by a cross-over GxE, rather than a main genetic effect. More... Significant
Amstadter, A. B.,2009 Post-hurricane PTSD symptoms Genotype: with posthurricane PTSD symptoms, B=0.02, t=0.13,...... Genotype: with posthurricane PTSD symptoms, B=0.02, t=0.13, P-value=0.89. More... No significant signals was observed about this SNP with post...... No significant signals was observed about this SNP with posthurricane PTSD symptoms. More... Non-significant
Dunn, E. C.,2014 Post-traumatic stress symptoms (PTS) T4: joint test P-value> 0.05, variant P-value> 0.05. T4: joint test P-value> 0.05, variant P-value> 0.05. We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTS (P-values > 0.05). More... Non-significant
G*E study related association result (count: 4)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Amstadter, A. B.,2009 Lifetime PTSD symptoms PTE/hurricane exposure, Social support Three-way interaction (genotype by hurricane exposure by soc...... Three-way interaction (genotype by hurricane exposure by social support), lifetime PTSD symptoms: B= 1.12, t=3.71, P-value< .001. More... Neither of the two-way interactions (genotype by hurricane e...... Neither of the two-way interactions (genotype by hurricane exposure and genotype by social support) was a significant predictor of posthurricane or lifetime PTSD symptoms. The three-way interaction (genotype by hurricane exposure by social support),however, was significantly predictive in both models. The same pattern of results was found when conducting these analyses with the sample restricted to Caucasian participants, and when controlling for the effects of the 5HTTLPR genotype. More... Significant
Dunn, E. C.,2014 Post Traumatic Growth (PTG) Hurricane exposure T4: joint test P-value=0.0044, GxE interaction P-value=0.006...... T4: joint test P-value=0.0044, GxE interaction P-value=0.006. More... We found a significant association between RGS2 and PTG, whi...... We found a significant association between RGS2 and PTG, which was mainly driven by a cross-over GxE, rather than a main genetic effect. At low levels of Katrina exposure, the G allele (minor allele) was associated with lower PTG (indicating less PTG). However, at moderate and high exposure, the G allele was associated with higher PTG scores (indicating more PTG; refer to Figure 1). This result withstood correction for multiple testing. In this model, the GxE explained 3.9% of the variability in PTG. More... Significant
Amstadter, A. B.,2009 Post-hurricane PTSD symptoms PTE/hurricane exposure, Social support Three-way interaction (genotype by hurricane exposure by soc...... Three-way interaction (genotype by hurricane exposure by social support), posthurricane PTSD symptoms: B=.58, t=2.18, P-value=.029. More... Neither of the two-way interactions (genotype by hurricane e...... Neither of the two-way interactions (genotype by hurricane exposure and genotype by social support) was a significant predictor of posthurricane or lifetime PTSD symptoms. The three-way interaction (genotype by hurricane exposure by social support),however, was significantly predictive in both models. The same pattern of results was found when conducting these analyses with the sample restricted to Caucasian participants, and when controlling for the effects of the 5HTTLPR genotype. More... Significant
Dunn, E. C.,2014 Post-traumatic stress symptoms (PTS) Hurricane exposure Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More... We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
RGS2 regulator of G-protein signaling 2 1q31 7(2/5/0)

SNPs in LD with rs4606 (count: 26)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 25)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
WNT3 No Adipose Subcutaneous cis GTEx