PTSDgene database

SNP Report

Basic Info
Name rs116647843 dbSNP Ensembl
Location 6:15533609 - 15533609(+)
Variant Seq A
Ancestral Allele G
Ref Seq G
Minor Allele Frequence 0.0071885
Annotation upstream_gene_variant; intron_variant; NMD_transcript_variant
Variant Effect upstream_gene_variant(ENST00000514651); intron_variant(ENST00000510395, ENST00000509674, LRG_588t2, ENST00000513680, ENST00000344537, ENST00000506844, ENST00000515875, ENST00000622898, ENST00000462989, LRG_588t1, ENST00000338950, ENST00000511762, ENST00000355917); NMD_transcript_variant(ENST00000510395, ENST00000513680, ENST00000506844, ENST00000515875)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000509674, ENST00000511762, LRG_588t1, ENST00000355917, ENST00000462989, ENST00000515875, ENST00000338950, LRG_588t2, ENST00000622898, ENST00000344537)
PolyPhen Annotation benign; possibly_damaging; probably_damaging
PolyPhen Variant Effect benign(ENST00000511762, ENST00000355917, ENST00000515875); possibly_damaging(ENST00000462989, ENST00000338950, LRG_588t2, ENST00000622898); probably_damaging(ENST00000509674, LRG_588t1, ENST00000344537)
rSNP? Yes Link in rVarBase
Related Regulatory Elements TF binding region
Chromatin State Weak transcription;Strong transcription;Enhancers;Genic enhancers;Flanking Active TSS;ZNF genes & repeats
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Nievergelt, C. M.,2015 PTSD In 2179 MRS subjects of European descent: P-value=0.06. In 2179 MRS subjects of European descent: P-value=0.06. No significant result. No significant result. Non-significant
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Nievergelt, C. M.,2015 PTSD Childhood trauma In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More... It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
DTNBP1 dystrobrevin binding protein 1 6p22.3 5(2/3/0)

SNPs in LD with rs116647843 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx