SNP Report

Basic Info

Name	rs6314 dbSNP Ensembl
Location	13:46834899 - 46834899(+)
Variant Seq	A
Ancestral Allele	G
Ref Seq	G
Minor Allele Frequence	0.0746805
Annotation	missense_variant
Variant Effect	missense_variant(ENST00000543956, ENST00000378688, ENST00000542664)
SIFT Annotation	tolerated_-_low_confidence; tolerated
SIFT Variant Effect	tolerated_-_low_confidence(ENST00000543956); tolerated(ENST00000378688, ENST00000542664)
PolyPhen Annotation	benign
PolyPhen Variant Effect	benign(ENST00000543956, ENST00000378688, ENST00000542664)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Weak transcription
No. of Marker's Association Results	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Nievergelt, C. M.,2015	PTSD	In 2179 MRS subjects of European descent: P-value=0.049. In 2179 MRS subjects of European descent: P-value=0.049.	P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05).	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Statistical Values	Author Comments	Marker's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More...	It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	13q14-q21	4(2/2/0)

SNPs in LD with rs6314 (count: 6)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs57667085	rs6314	intron_variant	1.0000[EUR]; 0.8858[AMR]
rs7325168	rs6314	3_prime_UTR_variant	1.0000[EUR]; 0.9626[AMR]
rs7323441	rs6314	3_prime_UTR_variant	1.0000[EUR]; 0.9626[AMR]
rs9534491	rs6314	downstream_gene_variant	1.0000[EUR]; 0.9479[AFR]; 0.9614[AMR]
rs9595552	rs6314	3_prime_UTR_variant	1.0000[EUR]; 0.9626[AMR]
rs7324218	rs6314	3_prime_UTR_variant	1.0000[EUR]; 0.9626[AMR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
RP11-707O23.5	No	Adipose Subcutaneous	cis	GTEx