Gene Report

Basic Info

Approved Symbol	CRP
Symbol Alias	PTX1
Approved Name	C-reactive protein, pentraxin-related
Name Alias	pentraxin 1
Location	1q23.2
Position	chr1:159712289-159714589, -1
External Links	HGNC: 2367 Entrez Gene: 1401 Ensembl: ENSG00000132693 UCSC: uc001ftw.3
No. of Association Results	3 (Positive: 2; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 3)

Reference	Phenotype	Marker	Gene's Category
Miller, M. W.,2018	Current PTSD severity	rs3091244	Non-significant
Michopoulos, V.,2015	PTSD diagnosis	rs1130864	Significant
Michopoulos, V.,2015	PTSD symptoms	rs1130864 ; rs1205 ; rs3091244 ; rs3093066 ; rs3093067 ; rs3093068	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Miller, M. W.,2018	Current PTSD severity	Lifetime trauma exposure	rs3091244	Significant

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0046790	virion binding	molecular function	IDA[23544079]	1
GO:0001849	complement component C1q binding	molecular function	IDA[23544079]	1
GO:2000482	regulation of interleukin-8 secretion	biological process	IDA[21037097]	1
GO:0008228	opsonization	biological process	TAS[2477488]	1
GO:0005615	extracellular space	cellular component	IDA[23544079]	27
GO:0045908	negative regulation of vasodilation	biological process	IDA[24141169' target='_blank'>24141169]; IMP[24141169]	1
GO:0030169	low-density lipoprotein particle binding	molecular function	IDA[18322245]	1
GO:0032930	positive regulation of superoxide anion generation	biological process	IDA[24141169]	1
GO:0005576	extracellular region	cellular component	NAS[14718574]	31
GO:0005509	calcium ion binding	molecular function	IDA[23544079]	9
GO:0070062	extracellular exosome	cellular component	IDA[23376485]	58
GO:0010628	positive regulation of gene expression	biological process	IDA[24141169]	14
GO:0006953	acute-phase response	biological process	TAS[2477488]	1
GO:0050830	defense response to Gram-positive bacterium	biological process	TAS[2477488]	6
GO:0010745	negative regulation of macrophage derived foam cell differentiation	biological process	IDA[18322245]	1
GO:0050750	low-density lipoprotein particle receptor binding	molecular function	IPI[24141169]	5
GO:0033265	choline binding	molecular function	TAS[2477488]	1
GO:0006954	inflammatory response	biological process	TAS[10408362]	10
GO:0005515	protein binding	molecular function	IPI[17785206\|21037097\|25416956]	169
GO:0010888	negative regulation of lipid storage	biological process	IDA[18322245]	2

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 20)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CRP	HIST2H2AC	No	--	--	1989977
CRP	DGCR14	No	--	--	21988832 , 21988832
CRP	FCGR1A	No	--	--	12471137
CRP	FCGR2A	No	--	--	17785206 , 10675363
CRP	GP6	No	--	--	11027634
CRP	CFH	No	--	--	10490997 , 10490997
CRP	FCN2	No	--	--	17581635 , 17581635 , 17581635
CRP	MAPK1	No	--	--	21988832 , 21988832
CRP	LAMC3	No	--	--	21988832 , 21988832
CRP	MAPK3	No	--	--	18624398 , 18624398
CRP	HIST1H1A	No	--	--	1989977 , 1989977
CRP	FN1	No	--	--	6693419 , 6693419
CRP	RPL13A	No	--	--	21988832 , 21988832
CRP	FCGR2B	No	--	--	12471137
CRP	FCGR2C	No	--	--	17785206 , 17785206
CRP	C1QA	No	--	--	10490997
CRP	APCS	No	--	--	8144569 , 8144569
CRP	SNRNP70	No	--	--	2477447 , 2477447
CRP	HIST1H2AG	No	--	--	1989977
CRP	LEP	No	--	--	16582918