PTSDgene database

Gene Report

Basic Info
Approved Symbol SLC6A4
Previous Symbol "HTT|OCD1"
Symbol Alias "5-HTT|SERT1"
Approved Name solute carrier family 6 (neurotransmitter transporter), member 4
Previous Name "solute carrier family 6 (neurotransmitter transporter, serotonin), member 4|5-hydroxytryptamine (serotonin) transporter|obsessive-compulsive disorder 1"
Name Alias serotonin transporter 1
Location 17q11.2
Position chr17:30194319-30236002, -1
External Links HGNC: 11050
Entrez Gene: 6532
Ensembl: ENSG00000108576
UCSC: uc002hey.5
No. of Association Results 44 (Positive: 13; Negative: 31; trend: 0)
Annotation Type Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target
Gene related association results
Normal genetic study related association results (count: 44)
Reference Phenotype Marker Gene's Category
Kovacic Petrovic, Z.,2016 PTSD severity 5-HTTLPR Non-significant
Zhao, L. S.,2012 PTSD 5-HTT_intron 2_VNTR Significant
Thakur, G. A., 2009 Acute PTSD 5-HTTLPR Non-significant
Walsh, K.,2014 Arousal symptoms 5-HTTLPR Non-significant
Walsh, K.,2014 Avoidance symptoms 5-HTTLPR Non-significant
Wang, Z.,2011 CAPS score 5-HTTLPR Significant
Thakur, G. A., 2009 Chronic PTSD 5-HTTLPR Non-significant
Koenen, K. C.,2009 Current diagnosis of PTSD 5-HTTLPR Non-significant
Liu, Y.,2015 Current diagnosis of PTSD 5-HTTLPR Significant
Xie, P.,2009 Lifetime PTSD 5-HTTLPR Non-significant
Kolassa, I. T.,2010 Lifetime PTSD 5-HTTLPR Significant
Xie, P.,2012 Lifetime PTSD 5-HTTLPR Non-significant
Walsh, K.,2014 Numbing symptoms 5-HTTLPR Non-significant
Kimbrel, N. A.,2015 PCL-M scores 5-HTTLPR Significant
Dunn, E. C.,2014 Post Traumatic Growth (PTG) 5-HTTLPR Non-significant
Kilpatrick, D. G.,2007 Post-hurricane PTSD 5-HTTLPR Non-significant
Mercer, K. B.,2012 Postshooting PTSD symptoms score (delta DEQ >1 month) 5-HTTLPR ; 5-HTTLPR multimarker ; STin2 ; rs25531 Non-significant
Holman, E. A.,2011 Posttraumatic stress (PTS) symptoms 2 years after 9/11 5-HTTLPR Non-significant
Holman, E. A.,2011 Posttraumatic stress (PTS) symptoms 3 years after 9/11 5-HTTLPR Non-significant
Dunn, E. C.,2014 Post-traumatic stress symptoms (PTS) 5-HTTLPR Non-significant
Mellman, T. A.,2009 PTSD 5-HTTLPR Non-significant
Navarro-Mateu, F.,2013 PTSD 5-HTTLPR Non-significant
Gressier, F.,2013 PTSD 5-HTTLPR Non-significant
Tian, Y.,2015 PTSD 5-HTTLPR ; 5-HTTVNTR Significant
Telch, M. J.,2015 PTSD 5-HTTLPR Non-significant
Valente, N. L.,2011 PTSD 5-HTTLPR Non-significant
Grabe, H. J.,2009 PTSD category B symptom score 5-HTTLPR Non-significant
Grabe, H. J.,2009 PTSD category C symptom score 5-HTTLPR Non-significant
Grabe, H. J.,2009 PTSD category D symptom score 5-HTTLPR Non-significant
Grabe, H. J.,2009 PTSD diagnosis 5-HTTLPR Significant
Pietrzak, R. H.,2013 PTSD diagnosis 5-HTTLPR Non-significant
Wang, Z.,2011 PTSD severity 5-HTTLPR Significant
Walsh, K.,2014 PTSD severity 5-HTTLPR Significant
Wang, Z.,2011 PTSD status 5-HTTLPR Significant
La Greca, A. M.,2013 PTSD symptoms 5-HTTLPR Non-significant
Goenjian, A. K.,2012 PTSD-RI (PTSD symptoms) 5-HTTLPR Non-significant
Olsson, A.,2015 PTSS scores 5-HTTLPR Significant
Kimbrel, N. A.,2015 QOLS scores 5-HTTLPR Significant
Walsh, K.,2014 Reexperiencing symptoms 5-HTTLPR Non-significant
Pietrzak, R. H.,2013 Severity of PTSD symptoms 5-HTTLPR Non-significant
Lee, H. J.,2005 PTSD diagnosis SERTPR Significant
Nievergelt, C. M.,2015 PTSD rs28914827 Non-significant
Solovieff, N.,2014 PTSD diagnosis rs12939390 Non-significant
Solovieff, N.,2014 PTSD severity rs12939390 Non-significant
G*E study related association result (count: 1)
Reference Phenotype Environment Marker Gene's Category
Pietrzak, R. H.,2013 Anxious arousal symptoms High exposure 5-HTTLPR ; 5-HTTLPR multimarker ; rs25531 ; STin2 ; rs28914827 ; 5-HTTVNTR Significant
Gene functional annotation
Gene related GO terms (count: 47)

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 5)