SNP Report
Basic Info
| Name | rs10737854 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 1:241186819 - 241186819(+) | ||
| Variant Seq | A | ||
| Ancestral Allele | G | ||
| Ref Seq | G | ||
| Minor Allele Frequence | 0.433506 | ||
| Annotation | intron_variant | ||
| Variant Effect | intron_variant(ENST00000366563, ENST00000348120, ENST00000366565, ENST00000366564) | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000366563, ENST00000348120, ENST00000366564, ENST00000401882, ENST00000366565) | ||
| PolyPhen Annotation | benign; possibly_damaging | ||
| PolyPhen Variant Effect | benign(ENST00000366563, ENST00000348120, ENST00000366564, ENST00000401882); possibly_damaging(ENST00000366565) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 0; Trend: 1) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | In subjects of European: P-value=4.6E-06. In subjects of European: P-value=4.6E-06. | It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More... | Trend |
G*E study related association result (count: 1)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | Childhood trauma | Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More... | It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More... | Non-significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| RGS7 | regulator of G-protein signaling 7 | 1q43 | 1(0/0/1) |
SNPs in LD with rs10737854 (count: 1)
Literature-origin SNPs (count: 0)
LD-proxies (count: 1)
SNP related eQTL (count: 1)