PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation de Quervain, D. J., et al. (2012). "PKCalpha is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors." Proc Natl Acad Sci U S A 109(22): 8746-8751.
Phenotype Reexperiencing symptoms, Avoidance symptoms, Hyperarousal symptoms, PTSD
Trauma Rwandan Civil War (refugees)
Study Design Case-control
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 347 refugees
SNP/Marker Size 2,005 SNPs
Predominant Ethnicity Black
Population Rwanda,Uganda
Gender 163 males, 184 females
Age Median age=34 years, range from 17 to 68 years.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 4)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs4790904 PTSD PRKCA A allele of rs4790904 with increased risk for PTSD: P-value=0.009. The A allele of rs4790904 was associated with increased risk...... The A allele of rs4790904 was associated with increased risk for PTSD. More... Significant
rs4790904 Avoidance symptoms PRKCA A allele of rs4790904 with increased avoidance symptoms: P-value=0.037. The A allele of rs4790904 was associated with increased avoi...... The A allele of rs4790904 was associated with increased avoidance symptoms. More... Significant
rs4790904 Hyperarousal symptoms PRKCA P-value>0.05. SNP rs4790904 was not associated with hyperarousal symptoms. SNP rs4790904 was not associated with hyperarousal symptoms. Significant
rs4790904 Reexperiencing symptoms PRKCA With symptoms of reexperiencing the traumatic event (traumatic memory) in the healthy population: P-value=0.033. PRKCA SNP rs4790904 was significantly associated with sympto...... PRKCA SNP rs4790904 was significantly associated with symptoms of reexperiencing the traumatic event (traumatic memory) with the same direction of effect as with memory for negative information in the healthy population. More... Significant

Gene * Environment result reported by this study (count: 1)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
rs4790904 PTSD PRKCA Sex Sex x SNP interaction: P-value >= 0.7. Sex did not influence the genotype effect on traumatic memor...... Sex did not influence the genotype effect on traumatic memory or PTSD risk. More... Non-significant