Gene Report

Basic Info

Approved Symbol	RORA
Symbol Alias	"RZRA\|ROR1\|ROR2\|ROR3\|NR1F1"
Approved Name	RAR related orphan receptor A
Previous Name	RAR-related orphan receptor A
Location	15q21-q22
Position	chr15:60488284-61229319, -1
External Links	HGNC: 10258 Entrez Gene: 6095 Ensembl: ENSG00000069667 UCSC: uc002agv.3
No. of Association Results	6 (Positive: 4; Negative: 2; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 6)

Reference	Phenotype	Marker	Gene's Category
Cao, C.,2017	PTSD symptom severity	rs8042149	Non-significant
Ashley-Koch, A. E.,2015	Current PTSD	rs8042149	Non-significant
Lowe, S. R.,2015	High versus low posttraumatic stress trajectory	rs893290	Significant
Lowe, S. R.,2015	Increasing versus decreasing posttraumatic stress trajectory	rs16942660	Significant
Logue, M. W.,2013	PTSD	rs11071561 ; rs11071587 ; rs11071588 ; rs16942660 ; rs4775301 ; rs8024133 ; rs8041061 ; rs8042149 ; rs893290	Significant
Nievergelt, C. M.,2015	PTSD	rs12442490	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Cao, C.,2017	PTSD symptom severity	Earthquake exposure	rs8042149 ; rs893290 ; rs12442490	Significant

Gene functional annotation

Gene related GO terms (count: 50)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0006805	xenobiotic metabolic process	biological process	ISS	9
GO:0008142	oxysterol binding	molecular function	IDA[19965867]	1
GO:0010575	positive regulation of vascular endothelial growth factor production	biological process	IMP[18658046]	3
GO:0005654	nucleoplasm	cellular component	TAS	43
GO:0050728	negative regulation of inflammatory response	biological process	IMP[11252722]	5
GO:0045599	negative regulation of fat cell differentiation	biological process	ISS	2
GO:0010467	gene expression	biological process	TAS	16
GO:0071347	cellular response to interleukin-1	biological process	IEA	1
GO:0005634	nucleus	cellular component	IDA[18658046\|19965867]	81
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	molecular function	IDA[19955433]	5
GO:0004879	RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding	molecular function	IEA	2
GO:0043030	regulation of macrophage activation	biological process	IEA	1
GO:0003677	DNA binding	molecular function	IDA[7926749\|9328355\|11053433]	13
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IMP[11252722]	1
GO:0001525	angiogenesis	biological process	IMP[18658046]	5
GO:0010906	regulation of glucose metabolic process	biological process	ISS	1
GO:0001223	transcription coactivator binding	molecular function	IPI[9862959\|10478845]	1
GO:0008270	zinc ion binding	molecular function	IEA	26
GO:0007623	circadian rhythm	biological process	TAS	5
GO:0003707	steroid hormone receptor activity	molecular function	IEA	2
GO:0021930	cerebellar granule cell precursor proliferation	biological process	ISS	1
GO:0072539	T-helper 17 cell differentiation	biological process	ISS	1
GO:0008013	beta-catenin binding	molecular function	IEA	2
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[7926749]	11
GO:0003700	transcription factor activity, sequence-specific DNA binding	molecular function	IDA[7926749\|9328355\|11053433\|17545671\|18658046]	9
GO:0008589	regulation of smoothened signaling pathway	biological process	ISS	1
GO:0043401	steroid hormone mediated signaling pathway	biological process	IEA	2
GO:0006355	regulation of transcription, DNA-templated	biological process	IDA[9328355]	14
GO:0001222	transcription corepressor binding	molecular function	IPI[9328355]	1
GO:0006809	nitric oxide biosynthetic process	biological process	IEA	2
GO:0001046	core promoter sequence-specific DNA binding	molecular function	IDA[21628546]	2
GO:0042753	positive regulation of circadian rhythm	biological process	ISS	1
GO:0071356	cellular response to tumor necrosis factor	biological process	IEA	3
GO:0030522	intracellular receptor signaling pathway	biological process	IDA[19965867]	2
GO:0005515	protein binding	molecular function	IPI[14701856\|16713569\|18354202\|22170608\|25416956]	169
GO:0032922	circadian regulation of gene expression	biological process	ISS	4
GO:0036315	cellular response to sterol	biological process	IDA[19965867]; IMP[18658046]	1
GO:0060850	regulation of transcription involved in cell fate commitment	biological process	ISS	1
GO:0021702	cerebellar Purkinje cell differentiation	biological process	IEA	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[17545671\|19955433]	25
GO:0043565	sequence-specific DNA binding	molecular function	IDA[11053433]	5
GO:0070328	triglyceride homeostasis	biological process	IMP[11053433]	5
GO:0046068	cGMP metabolic process	biological process	IEA	1
GO:0008134	transcription factor binding	molecular function	IPI[9862959\|18658046]	5
GO:0098531	transcription factor activity, direct ligand regulated sequence-specific DNA binding	molecular function	IDA[19965867]	1
GO:0042692	muscle cell differentiation	biological process	IMP[9862959]	1
GO:0019218	regulation of steroid metabolic process	biological process	ISS	1
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	5
GO:2000188	regulation of cholesterol homeostasis	biological process	ISS	1
GO:0071456	cellular response to hypoxia	biological process	IMP[18658046]	4

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 20)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
RORA	LMO3	No	--	--	16713569 , 16713569 , 16713569
RORA	NR0B1	No	--	--	16713569 , 16713569 , 16713569 , 16713569 , 16713569 , 16713569 , 16713569 , 16713569 , 16713569
RORA	EIF3I	No	--	--	15604093 , 15604093
RORA	PSMC5	No	--	--	16189514 , 16713569 , 16189514 , 16189514 , 16713569 , 16713569 , 16713569
RORA	MED1	No	--	--	10478845
RORA	EP300	No	--	--	9862959 , 9862959 , 9862959
RORA	LRIF1	No	--	--	17455211
RORA	HDAC7	No	--	--	22318606
RORA	NCOA1	No	--	--	15604093
RORA	PNRC1	No	--	--	15604093 , 15604093
RORA	VPRBP	No	--	--	23063525 , 23063525
RORA	RUVBL1	No	--	--	18087039 , 18087039
RORA	DDB1	No	--	--	23063525 , 23063525
RORA	NCOA2	No	--	--	10478845
RORA	ZXDC	No	--	--	15604093 , 15604093
RORA	PROX1	No	--	--	15604093 , 15604093
RORA	COPS5	No	--	--	15604093 , 15604093
RORA	EZH2	No	--	--	23063525 , 23063525
RORA	PNRC2	No	--	--	15604093 , 15604093
RORA	SMARCD3	No	--	--	14701856 , 14701856