PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Walsh, K.,2014 PMID: 24751314
Citation	Walsh, K., et al. (2014). "Associations between the SS variant of 5-HTTLPR and PTSD among adults with histories of childhood emotional abuse: results from two African American independent samples." J Affect Disord 161: 91-96.
Phenotype	PTSD severity, Reexperiencing symptoms, Avoidance symptoms, Numbing symptoms, Arousal symptoms
Trauma	Not mentioned.
Study Design	Case-control
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	136 DNHS and 546 GTP (both are African American)
SNP/Marker Size	1 Variant
Predominant Ethnicity	Black
Population	African American
Gender	DNHS: 93 female (68.4%); GTP: 335 female (61.4%).
Age	DNHS: mean age=54.57 years, SD=16.25; GTP: mean age=40.91 years, SD=13.86.

Detail Info

Sample Diagnosis	DSM-IV-TR
Related Diagnostic Tools	PTSD Checklist-Specific version(PCL-S), Traumatic Experiences Inventory (TEI), Modified PTSD Symptom Scale (MPSS), Childhood Trauma Questionnaire (CTQ).
Sample Status	None
Controls Exposed	Not mentioned.
Replication Size	None
Result Summary	Results: In both African American samples, 5-HTTLPR genotype modified the effect of emotional abuse on PTSD symptom severity. Participants with the low-expression SS genotype who were exposed to emotional abuse had significantly lower reexperiencing and arousal symptom severity scores. Conclusions: The SS variant of 5-HTTLPR appears to buffer against developing the reexperiencing and arousal symptoms of PTSD in two independent African American samples exposed to childhood emotional abuse. Findings also highlight the importance of considering emotional abuse experiences in patients with suspected PTSD.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 5)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
5-HTTLPR	Numbing symptoms	SLC6A4	5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-value>0.1.	Among DNHS or GTP participants, 5-HTTLPR did not have a main...... Among DNHS or GTP participants, 5-HTTLPR did not have a main effect on any of the PTSD symptom clusters. More...	Non-significant
5-HTTLPR	PTSD severity	SLC6A4	5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-value<0.05.	Among DNHS participants, 5-HTTLPR did not have a main effect...... Among DNHS participants, 5-HTTLPR did not have a main effect on PTSD symptom total. Among GTP participants, 5-HTTLPR genotype exerted a significant main effect on total PTSD symptom severity such that those with the low expression/SS alleles had lower total PTSD symptom severity relative to those with the higher expression/SL or LL alleles. More...	Significant
5-HTTLPR	Arousal symptoms	SLC6A4	5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-value>0.1.	Among DNHS or GTP participants, 5-HTTLPR did not have a main...... Among DNHS or GTP participants, 5-HTTLPR did not have a main effect on any of the PTSD symptom clusters. More...	Non-significant
5-HTTLPR	Avoidance symptoms	SLC6A4	5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-value>0.1.	Among DNHS or GTP participants, 5-HTTLPR did not have a main...... Among DNHS or GTP participants, 5-HTTLPR did not have a main effect on any of the PTSD symptom clusters. More...	Non-significant
5-HTTLPR	Reexperiencing symptoms	SLC6A4	5-HTTLPR main effect, in DNHS: P-value>0.1; in GTP: P-value>0.1.	Among DNHS or GTP participants, 5-HTTLPR did not have a main...... Among DNHS or GTP participants, 5-HTTLPR did not have a main effect on any of the PTSD symptom clusters. More...	Non-significant

Gene * Environment result reported by this study (count: 5)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
5-HTTLPR	Arousal symptoms	SLC6A4	Emotional Abuse	5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=5.80, P-value<0.01; in GTP: F-value=3.18, P-value<0.05. Any S allele interacted with emotional abuse: in DNHS, F(1,129) = 4.80, P-value= .03, and GTP, F(1,538) = 5.70, P-value= .017.	A significant interaction was observed between 5-HTTLPR geno...... A significant interaction was observed between 5-HTTLPR genotype and emotional abuse on worst arousal symptom severity after controlling for age and sex among DNHS participants. A significant interaction between 5-HTTLPR genotype and emotional abuse emerged for the arousal symptom clusters among GTP participants. More...	Significant
5-HTTLPR	Reexperiencing symptoms	SLC6A4	Emotional Abuse	5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=4.08, P-value<0.05; in GTP: F-value=3.56, P-value<0.05. In GTP, any S allele also interacted with emotional abuse to predict re-experiencing symptoms, F(1,538) = 3.76, P-value= .053.	A significant interaction was observed between 5-HTTLPR geno...... A significant interaction was observed between 5-HTTLPR genotype and emotional abuse on worst reexperiencing symptom severity after controlling for age and sex among DNHS participants. A significant interaction between 5-HTTLPR genotype and emotional abuse emerged for the reexperiencing symptom clusters among GTP participants. More...	Significant
5-HTTLPR	Avoidance symptoms	SLC6A4	Emotional Abuse	5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=0.46, P-value.0.1; in GTP: F-value=0.30, P-value>0.1.	The interaction between 5-HTTLPR and emotional abuse did not...... The interaction between 5-HTTLPR and emotional abuse did not reach statistical significance for the avoidance symptom severity among DNHS or GTP participants. More...	Non-significant
5-HTTLPR	PTSD severity	SLC6A4	Emotional Abuse	5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=2.67, P-value<0.1; in GTP: F-value=2.97, P-value<0.1.	The interaction between 5-HTTLPR and emotional abuse did not...... The interaction between 5-HTTLPR and emotional abuse did not reach statistical significance for total PTSD symptom severity among DNHS or GTP participants. More...	Non-significant
5-HTTLPR	Numbing symptoms	SLC6A4	Emotional Abuse	5-HTTLPR and Emotional Abuse interaction, in DNHS: F-value=0.44, P-value>0.1; in GTP: F-value=3.57, P-value<0.05.	The interaction between 5-HTTLPR and emotional abuse did not...... The interaction between 5-HTTLPR and emotional abuse did not reach statistical significance for the numbing symptom severity among DNHS participants. A significant interaction between 5-HTTLPR genotype and emotional abuse emerged for the numbing symptom clusters among GTP participants. More...	Significant