Gene Report

Basic Info

Approved Symbol	CACNA1C
Previous Symbol	"CCHL1A1\|CACNL1A1"
Symbol Alias	"Cav1.2\|CACH2\|CACN2\|TS\|LQT8"
Approved Name	calcium channel, voltage-dependent, L type, alpha 1C subunit
Location	12p13.3
Position	chr12:1970786-2697950, 1
External Links	HGNC: 1390 Entrez Gene: 775 Ensembl: ENSG00000151067 UCSC: uc001qjy.3
No. of Association Results	2 (Positive: 0; Negative: 2; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Marker	Gene's Category
Dunn, E. C.,2014	Post Traumatic Growth (PTG)	rs1006737	Non-significant
Dunn, E. C.,2014	Post-traumatic stress symptoms (PTS)	rs1006737	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Dunn, E. C.,2014	Post Traumatic Growth (PTG)	Hurricane exposure	rs1006737	Non-significant

Gene functional annotation

Gene related GO terms (count: 39)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007411	axon guidance	biological process	TAS	16
GO:0005829	cytosol	cellular component	IDA[12130699]	78
GO:0008217	regulation of blood pressure	biological process	IEA	5
GO:0030018	Z disc	cellular component	ISS	4
GO:0005245	voltage-gated calcium channel activity	molecular function	IDA[8392192\|12130699]; IMP[24728418]	1
GO:0061337	cardiac conduction	biological process	IMP[24728418]; TAS	2
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0043198	dendritic shaft	cellular component	IEA	3
GO:0006112	energy reserve metabolic process	biological process	TAS	3
GO:0042593	glucose homeostasis	biological process	IEA	7
GO:0005886	plasma membrane	cellular component	IDA[11206130]; TAS	99
GO:0002095	caveolar macromolecular signaling complex	cellular component	IEA	1
GO:0008331	high voltage-gated calcium channel activity	molecular function	TAS[11576544]	1
GO:0005737	cytoplasm	cellular component	IDA[11206130]	109
GO:0060083	smooth muscle contraction involved in micturition	biological process	IEA	1
GO:0051393	alpha-actinin binding	molecular function	IPI[17110593]	1
GO:0005515	protein binding	molecular function	IPI[11438518\|15140941\|20953164]	169
GO:0007628	adult walking behavior	biological process	IEA	3
GO:0030252	growth hormone secretion	biological process	IEA	2
GO:0046620	regulation of organ growth	biological process	IEA	1
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	biological process	TAS[11576544]	1
GO:0005516	calmodulin binding	molecular function	IPI[15140941]	4
GO:0016021	integral component of membrane	cellular component	IDA[8392192]	56
GO:0086010	membrane depolarization during action potential	biological process	IBA	1
GO:0070588	calcium ion transmembrane transport	biological process	IMP[24728418]	5
GO:0046872	metal ion binding	molecular function	IEA	20
GO:0017156	calcium ion regulated exocytosis	biological process	IEA	1
GO:0005891	voltage-gated calcium channel complex	cellular component	IDA[12130699]	1
GO:0008542	visual learning	biological process	IEA	6
GO:0019229	regulation of vasoconstriction	biological process	IEA	1
GO:0060402	calcium ion transport into cytosol	biological process	TAS[19095005]	1
GO:0030073	insulin secretion	biological process	IEA	2
GO:0086064	cell communication by electrical coupling involved in cardiac conduction	biological process	TAS[11576544]	1
GO:0014069	postsynaptic density	cellular component	IDA[14140941]	11
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IDA[12130699]	7
GO:0050796	regulation of insulin secretion	biological process	TAS	6
GO:0007268	synaptic transmission	biological process	IEA	32
GO:0035585	calcium-mediated signaling using extracellular calcium source	biological process	TAS[11576544]	1
GO:0043025	neuronal cell body	cellular component	IEA	18

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in PTSDgene
hsa04720	Long-term potentiation	6
hsa04930	Type II diabetes mellitus	2
hsa04010	MAPK signaling pathway	13
hsa04912	GnRH signaling pathway	4
hsa04020	Calcium signaling pathway	11

Gene related interactors from protein-protein interactions data in PINA v2 (count: 7)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CACNA1C	SIRT1	No	--	--	19343720 , 19343720
CACNA1C	COPS5	No	--	--	16483597
CACNA1C	CAND1	No	--	--	21145461
CACNA1C	CABP1	No	--	--	15140941 , 15140941 , 15140941 , 15140941 , 15140941 , 15140941 , 15140941 , 15140941
CACNA1C	RIMS1	No	--	--	11438519
CACNA1C	RYR2	No	--	--	11576544 , 11576544
CACNA1C	DERL1	No	--	--	21186355