PTSDgene database

SNP Report

Basic Info
Name rs363238 dbSNP Ensembl
Location 10:117279248 - 117279248(+)
Variant Seq A
Ancestral Allele C
Ref Seq C
Minor Allele Frequence 0.221845
Annotation non_coding_transcript_exon_variant; 3_prime_UTR_variant; non_coding_transcript_variant
Variant Effect non_coding_transcript_exon_variant(ENST00000497497); 3_prime_UTR_variant(ENST00000298472, ENST00000334464); non_coding_transcript_variant(ENST00000497497)
SIFT Annotation deleterious
SIFT Variant Effect deleterious(ENST00000334464)
PolyPhen Annotation probably_damaging
PolyPhen Variant Effect probably_damaging(ENST00000334464)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Strong transcription
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Nievergelt, C. M.,2015 PTSD In 2179 MRS subjects of European descent: P-value=0.022. In 2179 MRS subjects of European descent: P-value=0.022. P-value is nominally significant (P-value<0.05). P-value is nominally significant (P-value<0.05). Significant
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Nievergelt, C. M.,2015 PTSD Childhood trauma In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More... It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More... Non-significant


SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 10q25 3(2/1/0)
PDZD8 PDZ domain containing 8 10q26.12 Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

SNPs in LD with rs363238 (count: 35)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 35)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-259G18.3 No Adipose Subcutaneous cis GTEx