PTSDgene database

SNP Report

Basic Info
Name rs3091244 dbSNP Ensembl
Location 1:159714875 - 159714875(+)
Variant Seq A,T
Ancestral Allele G
Ref Seq G
Minor Allele Frequence 0.243011
Annotation upstream_gene_variant
Variant Effect upstream_gene_variant(ENST00000489317, ENST00000437342, ENST00000368111, ENST00000473196, ENST00000368112, ENST00000368110, ENST00000255030)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000255030)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000255030)
rSNP? No Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Inactive region
No. of Marker's Association Results 2 (Positive: 0; Negative: 2; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 2)
Reference Phenotype Statistical Values Author Comments Marker's Category
Miller, M. W.,2018 Current PTSD severity B=0.062, P-value=0.334 B=0.062, P-value=0.334 Main effect of this SNP is not significant. Main effect of this SNP is not significant. Non-significant
Michopoulos, V.,2015 PTSD symptoms T=0.39, P-value=0.70 T=0.39, P-value=0.70 No significant effect on PTSD symptoms. No significant effect on PTSD symptoms. Non-significant
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Miller, M. W.,2018 Current PTSD severity Lifetime trauma exposure B=2.756, P-value=0.006 B=2.756, P-value=0.006 Rs3091244 moderated the association between lifetime trauma ...... Rs3091244 moderated the association between lifetime trauma exposure and current PTSD severity. More... Significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CRP C-reactive protein, pentraxin-related 1q23.2 3(2/1/0)

SNPs in LD with rs3091244 (count: 18)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 17)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx