SNP Report

Basic Info

Name	rs3091244 dbSNP Ensembl
Location	1:159714875 - 159714875(+)
Variant Seq	A,T
Ancestral Allele	G
Ref Seq	G
Minor Allele Frequence	0.243011
Annotation	upstream_gene_variant
Variant Effect	upstream_gene_variant(ENST00000489317, ENST00000437342, ENST00000368111, ENST00000473196, ENST00000368112, ENST00000368110, ENST00000255030)
SIFT Annotation	tolerated
SIFT Variant Effect	tolerated(ENST00000255030)
PolyPhen Annotation	benign
PolyPhen Variant Effect	benign(ENST00000255030)
rSNP?	No Link in rVarBase
Related Regulatory Elements	n/a
Chromatin State	Inactive region
No. of Marker's Association Results	2 (Positive: 0; Negative: 2; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Miller, M. W.,2018	Current PTSD severity	B=0.062, P-value=0.334 B=0.062, P-value=0.334	Main effect of this SNP is not significant. Main effect of this SNP is not significant.	Non-significant
Michopoulos, V.,2015	PTSD symptoms	T=0.39, P-value=0.70 T=0.39, P-value=0.70	No significant effect on PTSD symptoms. No significant effect on PTSD symptoms.	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Statistical Values	Author Comments	Marker's Category
Miller, M. W.,2018	Current PTSD severity	Lifetime trauma exposure	B=2.756, P-value=0.006 B=2.756, P-value=0.006	Rs3091244 moderated the association between lifetime trauma ...... Rs3091244 moderated the association between lifetime trauma exposure and current PTSD severity. More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
CRP	C-reactive protein, pentraxin-related	1q23.2	3(2/1/0)

SNPs in LD with rs3091244 (count: 18)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Annotation	No. of Association Results(Positive/Negative/Trend)	r²[population]

rs1130864	3_prime_UTR_variant(ENST00000255030); intron_variant(ENST00000473196, ENST00000489317, ENST00000437342, ENST00000368112, ENST00000368110, ENST00000368111); non_coding_transcript_variant(ENST00000473196, ENST00000489317)	2(2/0/0)	0.9193[EUR]

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs1417938	rs3091244	upstream_gene_variant; intron_variant	0.9193[EUR]
rs12727021	rs3091244	upstream_gene_variant	0.9079[EUR]
rs4261114	rs3091244	upstream_gene_variant	0.9079[EUR]
rs12755606	rs3091244	downstream_gene_variant	0.8794[EUR]
rs12739022	rs3091244	downstream_gene_variant	0.8680[EUR]
rs12749227	rs3091244	downstream_gene_variant	0.8737[EUR]
rs12741825	rs3091244	downstream_gene_variant	0.8794[EUR]
rs2369251	rs3091244	upstream_gene_variant	0.9193[EUR]
rs3116636	rs3091244	upstream_gene_variant	0.9193[EUR]
rs3122012	rs3091244	upstream_gene_variant	0.9079[EUR]
rs3116635	rs3091244	upstream_gene_variant	0.9193[EUR]
rs3116653	rs3091244	upstream_gene_variant; intron_variant	0.9079[EUR]
rs12754745	rs3091244	downstream_gene_variant	0.8794[EUR]
rs3116651	rs3091244	upstream_gene_variant	0.9079[EUR]
rs12754915	rs3091244	downstream_gene_variant	0.8737[EUR]
rs3116655	rs3091244	upstream_gene_variant	0.9079[EUR]
rs3116656	rs3091244	splice_donor_variant; missense_variant; upstream_gene_variant; intron_variant; splice_region_variant; non_coding_transcript_variant	0.9135[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
CRHR1	Yes	Adipose Subcutaneous	cis	GTEx