SNP Report
Basic Info
| Name | rs7866350 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 9:98221544 - 98221544(+) | ||
| Variant Seq | G,T | ||
| Ancestral Allele | C | ||
| Ref Seq | C | ||
| Minor Allele Frequence | 0.209065 | ||
| Annotation | intron_variant; non_coding_transcript_variant | ||
| Variant Effect | intron_variant(ENST00000342112, ENST00000493589, ENST00000375066, ENST00000375064, ENST00000465784); non_coding_transcript_variant(ENST00000493589) | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000375066, ENST00000465784, ENST00000342112, ENST00000375064) | ||
| PolyPhen Annotation | benign | ||
| PolyPhen Variant Effect | benign(ENST00000375066, ENST00000465784, ENST00000342112, ENST00000375064) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | Chromatin interactive region | ||
| Chromatin State | Weak transcription;Strong transcription;Enhancers;Genic enhancers | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 0; Trend: 1) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Ashley-Koch, A. E.,2015 | Current PTSD | In NHW subset: OR=2.27, main effect P-value=1.10E-06. In NHW subset: OR=2.27, main effect P-value=1.10E-06. |
This SNP was nominally significant with current PTSD among t......
This SNP was nominally significant with current PTSD among the NHW subset (P-value |
Trend |
G*E study related association result (count: 2)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Ashley-Koch, A. E.,2015 | Current PTSD | Childhood trauma | Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and child trauma interaction P-value=0.51. More... | We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More... | Non-significant |
| Ashley-Koch, A. E.,2015 | Current PTSD | NTE (number of traumatic events) | Logistic regression (additive genetic model) in NHW subset: ...... Logistic regression (additive genetic model) in NHW subset: snp and total trauma interaction P-value=0.15. More... | We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More... | Non-significant |
SNP related genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| TBC1D2 | TBC1 domain family member 2 | 9q22.32 | 1(0/0/1) |
| NANS | N-acetylneuraminate synthase | 9p24.1-p23 | rSNP target |
SNPs in LD with rs7866350 (count: 4)
Literature-origin SNPs (count: 0)
LD-proxies (count: 4)
SNP related eQTL (count: 1)