Gene Report

Basic Info

Approved Symbol	CHRNA4
Previous Symbol	"EBN\|EBN1"
Symbol Alias	BFNC
Approved Name	cholinergic receptor, nicotinic alpha 4
Previous Name	"cholinergic receptor, nicotinic, alpha polypeptide 4\|cholinergic receptor, nicotinic, alpha 4 (neuronal)"
Name Alias	acetylcholine receptor, nicotinic, alpha 4 (neuronal)
Location	20q13.33
Position	chr20:63343223-63378401, -1
External Links	HGNC: 1958 Entrez Gene: 1137 Ensembl: ENSG00000101204 UCSC: uc002yes.3
No. of Association Results	1 (Positive: 1; Negative: 0; trend: 0)
Annotation Type	Literature-origin

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Kimbrel, N. A.,2015	PTSD	rs1316971	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Kimbrel, N. A.,2015	PTSD	Smoking status	rs1316971	Non-significant

Gene functional annotation

Gene related GO terms (count: 38)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007274	neuromuscular synaptic transmission	biological process	IBA	5
GO:0016021	integral component of membrane	cellular component	NAS[8906617]	56
GO:0043025	neuronal cell body	cellular component	ISS	18
GO:0019233	sensory perception of pain	biological process	ISS	9
GO:0042166	acetylcholine binding	molecular function	IBA; IC[8906617]	8
GO:0005892	acetylcholine-gated channel complex	cellular component	IDA[8906617]	8
GO:0014059	regulation of dopamine secretion	biological process	ISS	6
GO:0007585	respiratory gaseous exchange	biological process	IEA	2
GO:0005886	plasma membrane	cellular component	ISS; TAS	99
GO:0035095	behavioral response to nicotine	biological process	IMP[17955458]	4
GO:0060080	inhibitory postsynaptic potential	biological process	ISS	3
GO:0030054	cell junction	cellular component	IEA	24
GO:0098655	cation transmembrane transport	biological process	IDA[8906617]; IEA; TAS[20438829]	8
GO:0034220	ion transmembrane transport	biological process	TAS[20438829]	9
GO:0001666	response to hypoxia	biological process	IDA[12189247]	13
GO:0006979	response to oxidative stress	biological process	IMP[16332175]	3
GO:0015464	acetylcholine receptor activity	molecular function	IDA[8906617]	8
GO:0016020	membrane	cellular component	ISS	42
GO:0004889	acetylcholine-activated cation-selective channel activity	molecular function	IDA[8906617]; TAS[20438829]	8
GO:0006811	ion transport	biological process	NAS[8906617]	10
GO:0051899	membrane depolarization	biological process	ISS	2
GO:0001508	action potential	biological process	ISS	3
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0035094	response to nicotine	biological process	IDA[12189247]	11
GO:0007626	locomotory behavior	biological process	IEA	9
GO:0006816	calcium ion transport	biological process	ISS	3
GO:0050890	cognition	biological process	IMP[14623738]	2
GO:0042113	B cell activation	biological process	ISS	1
GO:0015276	ligand-gated ion channel activity	molecular function	TAS[20438829]	4
GO:0009897	external side of plasma membrane	cellular component	ISS	9
GO:0007271	synaptic transmission, cholinergic	biological process	IBA; ISS	9
GO:0035640	exploration behavior	biological process	IEA	2
GO:0007165	signal transduction	biological process	IDA[8906617]	34
GO:0030425	dendrite	cellular component	ISS	19
GO:0050877	neurological system process	biological process	IMP[7550350\|17613539]	1
GO:0006281	DNA repair	biological process	IMP[16332175]	8
GO:0007268	synaptic transmission	biological process	NAS[7550350]; TAS	32
GO:0042391	regulation of membrane potential	biological process	ISS	4

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 5)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CHRNA4	VSNL1	No	--	--	12202488 , 12202488
CHRNA4	CSNK2B	No	--	--	21900206 , 21900206 , 21900206
CHRNA4	UBQLN1	No	--	--	16091357
CHRNA4	YWHAH	No	--	--	11352901 , 11352901
CHRNA4	CRELD2	No	--	--	16238698