SNP Report
Basic Info
| Name | rs6295 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 5:63962738 - 63962738(+) | ||
| Variant Seq | G | ||
| Ancestral Allele | G | ||
| Ref Seq | C | ||
| Minor Allele Frequence | 0.453275 | ||
| Annotation | upstream_gene_variant; intron_variant; non_coding_transcript_variant | ||
| Variant Effect | upstream_gene_variant(ENST00000323865, ENST00000506598); intron_variant(ENST00000502882); non_coding_transcript_variant(ENST00000502882) | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000323865) | ||
| PolyPhen Annotation | benign | ||
| PolyPhen Variant Effect | benign(ENST00000323865) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | TF binding region | ||
| Chromatin State | Bivalent/Poised TSS;Active TSS;Flanking Bivalent TSS/Enh;Bivalent Enhancer | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 1; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Donaldson, Z. R.,2016 | PTSD diagnosis | OR=1.282, P-value=0.128. Control for childhood trauma: OR=1....... OR=1.282, P-value=0.128. Control for childhood trauma: OR=1.265, P-value=0.175. Control for non-childhood trauma: OR=1.328, P-value=0.095. More... | We did not observe a significant association between rs6295 ...... We did not observe a significant association between rs6295 and current PTSD. More... | Non-significant |
G*E study related association result (count: 2)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Donaldson, Z. R.,2016 | PTSD diagnosis | Childhood trauma | P-value>0.05 P-value>0.05 | No significant associations were observed. No significant associations were observed. | Non-significant |
| Donaldson, Z. R.,2016 | PTSD diagnosis | Non-childhood trauma | P-value>0.05 P-value>0.05 | No significant associations were observed. No significant associations were observed. | Non-significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| HTR1A | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | 5q12.3 | 1(0/1/0) |
SNPs in LD with rs6295 (count: 1)
Literature-origin SNPs (count: 0)
LD-proxies (count: 1)
SNP related eQTL (count: 1)