PTSDgene database

SNP Report

Basic Info
Name rs6295 dbSNP Ensembl
Location 5:63962738 - 63962738(+)
Variant Seq G
Ancestral Allele G
Ref Seq C
Minor Allele Frequence 0.453275
Annotation upstream_gene_variant; intron_variant; non_coding_transcript_variant
Variant Effect upstream_gene_variant(ENST00000323865, ENST00000506598); intron_variant(ENST00000502882); non_coding_transcript_variant(ENST00000502882)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000323865)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000323865)
rSNP? Yes Link in rVarBase
Related Regulatory Elements TF binding region
Chromatin State Bivalent/Poised TSS;Active TSS;Flanking Bivalent TSS/Enh;Bivalent Enhancer
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Donaldson, Z. R.,2016 PTSD diagnosis OR=1.282, P-value=0.128. Control for childhood trauma: OR=1....... OR=1.282, P-value=0.128. Control for childhood trauma: OR=1.265, P-value=0.175. Control for non-childhood trauma: OR=1.328, P-value=0.095. More... We did not observe a significant association between rs6295 ...... We did not observe a significant association between rs6295 and current PTSD. More... Non-significant
G*E study related association result (count: 2)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Donaldson, Z. R.,2016 PTSD diagnosis Childhood trauma P-value>0.05 P-value>0.05 No significant associations were observed. No significant associations were observed. Non-significant
Donaldson, Z. R.,2016 PTSD diagnosis Non-childhood trauma P-value>0.05 P-value>0.05 No significant associations were observed. No significant associations were observed. Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5q12.3 1(0/1/0)

SNPs in LD with rs6295 (count: 1)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1-IT1 Yes Adipose Subcutaneous cis GTEx