SNP Report
Basic Info
| Name | rs73419609 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 15:54423444 - 54423444(+) | ||
| Variant Seq | G | ||
| Ancestral Allele | A | ||
| Ref Seq | A | ||
| Minor Allele Frequence | 0.0920527 | ||
| Annotation | intron_variant | ||
| Variant Effect | intron_variant(ENST00000260323) | ||
| SIFT Annotation | tolerated_-_low_confidence | ||
| SIFT Variant Effect | tolerated_-_low_confidence(ENST00000260323) | ||
| PolyPhen Annotation | benign | ||
| PolyPhen Variant Effect | benign(ENST00000260323) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 0; Trend: 1) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Ashley-Koch, A. E.,2015 | Current PTSD | In NHB subset: OR=0.45, main effect P-value=5.67E-06. In NHB subset: OR=0.45, main effect P-value=5.67E-06. |
This SNP was nominally significant with current PTSD among t......
This SNP was nominally significant with current PTSD among the NHB subset (P-value |
Trend |
G*E study related association result (count: 2)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Ashley-Koch, A. E.,2015 | Current PTSD | Childhood trauma | Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.049. More... | Among the NHB, we observed nominally significant interaction...... Among the NHB, we observed nominally significant interactions with childhood trauma for UNC13C. More... | Non-significant |
| Ashley-Koch, A. E.,2015 | Current PTSD | NTE (number of traumatic events) | Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.74. More... | We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More... | Non-significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| UNC13C | unc-13 homolog C (C. elegans) | 15q21.3 | 1(0/0/1) |
SNPs in LD with rs73419609 (count: 33)
Literature-origin SNPs (count: 0)
LD-proxies (count: 33)
SNP related eQTL (count: 1)