Study Report
Study Information
Basic Info
| Reference |
Kim, T. Y.,2013 PMID: 23761065
|
| Citation |
Kim, T. Y., et al. (2013). "Apolipoprotein E gene polymorphism, alcohol use, and their interactions in combat-related posttraumatic stress disorder." Depress Anxiety 30(12): 1194-1201. |
| Phenotype |
PTSD |
| Trauma |
Vietnam War |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study, Gene-environment interaction study |
| Sample Size |
128 cases, 128 controls |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Mongloid |
| Population |
Korean |
| Gender |
All males |
| Age |
PTSD: mean age=63.2 years, SD=3.5; Control: mean age=62.9 years, SD=4.3. |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
The Clinician-Administered PTSD Scale (CAPS), The intensity of combat-related trauma was evaluated using the Combat Exposure Scale (CES), Alcohol Use Disorders Identification Test (AUDIT) |
| Sample Status |
Subjects in the control group were recruited via advertisements placed at nonpsychiatry outpatient clinics in the same hospital. Interviews were conducted by a psychiatrist. Potential exclusion criteria included a history of head trauma, organic brain syndrome including cerebrovascular accidents or dementia, psychosis or bipolar disorder, or dependence on substances other than alcohol and nicotine. |
| Controls Exposed |
No |
| Replication Size |
None |
| Result Summary |
Higher frequencies of APOE euro2 alleles and a greater number of individuals with the euro2 allele were found in the PTSD group. Among patients with PTSD, euro2-allele noncarriers consumed alcohol in greater amounts and more frequently than did euro2-allele carriers. Regression analysis revealed a significant interactional effect between harmful drinking and the absence of the euro2 allele associated with PTSD risk. These results suggest that the APOE euro2 allele operates as a susceptibility gene for combat-related PTSD, with the relationship between alcohol use and PTSD differing according to the euro2-allele status. Future studies should determine the role of the APOE in adaptation to extreme stress, the development of PTSD, and comorbid alcohol-related disorders. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
APOE_euro2/euro3/euro4
|
PTSD |
APOE |
In the main effect model, absence of euro2 allele: P-value=0.007, adjusted OR=0.32, 95%CI=0.14-0.74. |
Allele frequencies differed significantly between the PTSD a......
Allele frequencies differed significantly between the PTSD and control groups. In addition, there were more euro2-allele carriers in the PTSD group than in the control group; however, no significant differences were observed between groups with respect to the numbers of euro3- and euro4-allele carriers. In the main effect model, the presence of PTSD increased with the intensity of combat trauma in a dose-dependent manner. In addition, both harmful drinking patterns and absence of the APOE euro2 allele were significantly associated with PTSD.
More...
|
Significant |
Gene * Environment result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Environment |
Statistical Values |
Author Comments |
Marker's Category |
|
APOE_euro2/euro3/euro4
|
PTSD |
APOE |
Harmful drinking |
In the interaction effect model, the harmful drinking x absence of APOE euro2-allele interaction: P-value=0.005, adjusted OR=2.56, 95%CI=1.32-4.97. Post hoc stratified analysis in euro2-allele noncarriers: P-value= .001, OR=2.54, 95%CI=1.44-4.46, in euro2-allele carriers: P-value=.271, OR=1.18, 95%CI=.29-4.83. |
In the interaction effect model, only the harmful drinking x......
In the interaction effect model, only the harmful drinking x absence of APOE euro2-allele interaction was statistically significant. Post hoc stratified analysis also revealed that harmful drinking was associated with an increased risk of PTSD in euro2-allele noncarriers but not in euro2-allele carrier.
More...
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Significant |
