PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Kolassa, I. T.,2010 PMID: 19944409
Citation	Kolassa, I. T., et al. (2010). "The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism." Biol Psychiatry 67(4): 304-308.
Phenotype	Lifetime PTSD, Probability of developing lifetime PTSD, Probability of suffering from lifetime PTSD
Trauma	1994 Rwandan civil war
Study Design	Case-control
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	424 survivors
SNP/Marker Size	1 SNP
Predominant Ethnicity	Black
Population	Uganda
Gender	226 male, 198 female
Age	Mean age=34.8 years, SD=5.8, age range 17-68.

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	Posttraumatic Diagnostic Scale (PDS), Depressive symptoms were assessed with the depression section of the Hopkins Symptom Checklist (HSCL-D). Traumatic events were assessed with a checklist of 36 war- and non-war-related traumatic event types (e.g., injury by weapon, rape, accident). Traumatic load was estimated by assessing the number of different traumatic event types experienced or witnessed.
Sample Status	Four hundred twenty-four Rwandese refugees from the 1994 Rwandan civil war who were living in the Nakivale refugee camp in southwestern Uganda were investigated.
Controls Exposed	Yes
Replication Size	None
Result Summary	Higher numbers of different lifetime traumatic event types led to a higher prevalence of lifetime PTSD in a dose-response relationship. However, this effect was modulated by the COMT genotype: whereas Val allele carriers showed the typical dose-response relationship, Met/Met homozygotes exhibited a high risk for PTSD independently of the severity of traumatic load. The present findings indicate a gene-environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 1)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs4680	Lifetime PTSD	COMT	Main effect of genotype on lifetime PTSD, LR=1.53, P-value=.47.	There was no main effect of genotype on lifetime PTSD. There was no main effect of genotype on lifetime PTSD.	Non-significant

Gene * Environment result reported by this study (count: 2)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs4680	Probability of developing lifetime PTSD	COMT	Traumatic load	Interaction of genotype by traumatic load: LR=10.49, P-value=.04.	However, the probability of developing lifetime PTSD exhibit...... However, the probability of developing lifetime PTSD exhibited a gene-environment interaction (i.e., an interaction of genotype by traumatic load). More...	Significant
rs4680	Probability of suffering from lifetime PTSD	COMT	Gender	Interactions of gender x genotype: P-value > .46.	There was no significant interactions of gender x genotype o...... There was no significant interactions of gender x genotype on the probability of suffering from lifetime PTSD. More...	Non-significant