PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Holman, E. A., et al. (2011). "Social constraints, genetic vulnerability, and mental health following collective stress." J Trauma Stress 24(5): 497-505.
Phenotype Posttraumatic stress (PTS) symptoms 2 years after 9/11, Posttraumatic stress (PTS) symptoms 3 years after 9/11
Trauma 2001 (9/11) terrorist attacks
Study Design Longitudinal design
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 711 respondents (463 European American)
SNP/Marker Size 1 Variant
Predominant Ethnicity Caucasian
Population European American
Gender In any short genotype group:52.4% female (n=176); in homozygotic long A genotype group:48.0% female (n=61).
Age In any short genotype group:mean age=51.77 years, SD=15.33 (n=336); in homozygotic long A genotype group:mean age=49.90 years, SD=15.87 (n=61).

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
5-HTTLPR Posttraumatic stress (PTS) symptoms 3 years after 9/11 SLC6A4 (Participant age, gender, pre-9/11 mental and physical health, 9/11-related exposure and acute stress, lifetime SLE, and amount of talking about future terrorism were included as controls) With controls: any short allele, b=-0.0219, SE=0.022, P-value>0.05. There isn't a significant association of any short allele wi...... There isn't a significant association of any short allele with PTSD symptoms 3 years after 9/11. More... Non-significant
5-HTTLPR Posttraumatic stress (PTS) symptoms 2 years after 9/11 SLC6A4 (Participant age, gender, pre-9/11 mental and physical health, 9/11-related exposure and acute stress, lifetime SLE, and amount of talking about future terrorism were included as controls) With controls: any short allele, b=-0.019, SE=0.019, P-value>0.05. There isn't a significant association of any short allele wi...... There isn't a significant association of any short allele with PTSD symptoms 2 years after 9/11. More... Non-significant

Gene * Environment result reported by this study (count: 2)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
5-HTTLPR Posttraumatic stress (PTS) symptoms 3 years after 9/11 SLC6A4 Social constraints any short allele x social constraints, with controls:b=0.032, SE=0.015, P-value<0.05 There was a significant positive association between social ...... There was a significant positive association between social constraints and PTS symptoms for individuals with and without short alleles (Table 3; Figure 1b). Although both simple slopes were significantly different from zero, the significant interaction term indicated that the association between social constraints and PTS symptoms for individuals with an s/lg allele was significantly stronger than the relationship between social constraints and PTS symptoms for la/la individuals. Under low social constraints, genotype was unrelated to PTS symptoms; under high social constraints, respondents with an s/lg allele reported significantly higher PTS symptoms than those with the la/la genotype. More... Significant
5-HTTLPR Posttraumatic stress (PTS) symptoms 2 years after 9/11 SLC6A4 Social constraints any short allele x social constraints, with controls:b=0.039, SE=0.013, P-value<=0.01 Genotype interacted with social constraints to predict highe...... Genotype interacted with social constraints to predict higher PTS symptoms. Examination of simple slopes revealed a significant positive association between social constraints and PTS symptoms for individuals with an s/lg allele but not for those individuals without an s/lg allele (see Figure 1a). Under low social constraints, genotype was unrelated to PTS symptoms; under high social constraints, respondents with an s/lg allele reported significantly higher PTS symptoms than those with the la/la genotype. More... Significant