PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Pietrzak, R. H., et al. (2013). "Examining the relation between the serotonin transporter 5-HTTPLR genotype x trauma exposure interaction on a contemporary phenotypic model of posttraumatic stress symptomatology: a pilot study." J Affect Disord 148(1): 123-128.
Phenotype Severity of PTSD symptoms, PTSD diagnosis, Anxious arousal symptoms, Reexperiencing symptoms, Avoidance symptoms, Numbing symptoms, Dysphoric arousal symptoms
Trauma Hurricane Ike
Study Design Case-control
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 149 respondents
SNP/Marker Size 1 Variant
Predominant Ethnicity Caucasian, Black
Population 71.2% were European American, and 28.8% were non-European American (10.3% Hispanic, 9.6% Black, and 8.9% other, non-Hispanic).
Gender 86 (58.9%) female
Age Mean age=53.1 years, SD=17.8, range from 18 to 92.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
5-HTTLPR PTSD diagnosis SLC6A4 S' allele: Wald=2.47, OR=7.46, 95%CI=0.61-91.46 Main effects of 5-HTTLPR genotype was not significant in the...... Main effects of 5-HTTLPR genotype was not significant in these analyses. More... Non-significant
5-HTTLPR Severity of PTSD symptoms SLC6A4 S' allele: B=0.15, P-value=0.08 (adjustment for age, sex, and ancestral proportion scores). Main effects of 5-HTTLPR genotype was not significant in the...... Main effects of 5-HTTLPR genotype was not significant in these analyses. More... Non-significant

Gene * Environment result reported by this study (count: 7)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
5-HTTLPR Dysphoric arousal symptoms SLC6A4 High exposure The interaction of 5-HTTPLR S' allele x exposure:B=.13, t=.93, P-value<=.36 Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was not significantly associated with dysphoric arousal symptoms. More... Non-significant
5-HTTLPR Anxious arousal symptoms SLC6A4 High exposure The interaction of 5-HTTPLR S' allele x exposure:B=.44, t=5.47, P-value<.001 Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was significantly associated with anxious arousal symptoms. More... Significant
5-HTTLPR Reexperiencing symptoms SLC6A4 High exposure The interaction of 5-HTTPLR S' allele x exposure:B=.35, t=4.56, P-value<<.001 Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was significantly associated with re-experiencing symptoms. More... Significant
5-HTTLPR Avoidance symptoms SLC6A4 High exposure The interaction of 5-HTTPLR S' allele x exposure:B=.08, t=.55, P-value<=.59 Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was not significantly associated with avoidance symptoms. More... Non-significant
5-HTTLPR Numbing symptoms SLC6A4 High exposure The interaction of 5-HTTPLR S' allele x exposure:B=.20, t=1.49, P-value<=.14 Secondary analyses revealed that the 5-HTTLPR S' allele x ex...... Secondary analyses revealed that the 5-HTTLPR S' allele x exposure interaction was not significantly associated with numbing symptoms. More... Non-significant
5-HTTLPR Diagnosis of PTSD SLC6A4 High exposure The interaction of 5-HTTPLR genotype x exposure: Wald=4.55, OR=3.81, 95%CI=1.11-13.03, P-value<0.05. Results of these analyses revealed that after adjustment for...... Results of these analyses revealed that after adjustment for age, sex, and ancestral proportion scores, the interaction of 5-HTTPLR genotype x exposure was significantly associated with probable diagnosis of Ike-related PTSD. More... Significant
5-HTTLPR Severity of PTSD symptoms SLC6A4 High exposure The interaction of 5-HTTPLR genotype x exposure: B=0.40, P-value<0.001. Results of these analyses revealed that after adjustment for...... Results of these analyses revealed that after adjustment for age, sex, and ancestral proportion scores, the interaction of 5-HTTPLR genotype x exposure was significantly associated with severity of Ike-related PTSD. More... Significant