PTSDgene database

SNP Report

Basic Info
Name rs80087508 dbSNP Ensembl
Location 15:78589891 - 78589891(+)
Variant Seq G
Ancestral Allele A
Ref Seq A
Minor Allele Frequence 0.00419329
Annotation downstream_gene_variant; non_coding_transcript_exon_variant; missense_variant; upstream_gene_variant; intron_variant; non_coding_transcript_variant
Variant Effect downstream_gene_variant(ENST00000348639, ENST00000559658, ENST00000559002); non_coding_transcript_exon_variant(ENST00000567141); missense_variant(ENST00000394802, ENST00000299565); upstream_gene_variant(ENST00000559576); intron_variant(ENST00000559554); non_coding_transcript_variant(ENST00000567141)
SIFT Annotation deleterious
SIFT Variant Effect deleterious(ENST00000394802, ENST00000299565)
PolyPhen Annotation probably_damaging
PolyPhen Variant Effect probably_damaging(ENST00000394802, ENST00000299565)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Strong transcription
No. of Marker's Association Results 1 (Positive: 1; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Kimbrel, N. A.,2015 PTSD In the NHB sample, main effect: P-value=0.01196. In the NHB sample, main effect: P-value=0.01196. Nominally significant associations (p<.05) were observed, bu...... Nominally significant associations (p<.05) were observed, but it didn't met multiple-testing threshold. More... Significant
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Kimbrel, N. A.,2015 PTSD Smoking status GxE interactions among NHB participants: P-value=0.9147. GxE interactions among NHB participants: P-value=0.9147. No GxE interactions were statistically significant among NHB...... No GxE interactions were statistically significant among NHB participants. More... Non-significant


SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CHRNA3 cholinergic receptor, nicotinic alpha 3 15q24 1(0/1/0)
CHRNA5 cholinergic receptor, nicotinic alpha 5 15q24 2(1/1/0)

SNPs in LD with rs80087508 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-259G18.3 No Adipose Subcutaneous cis GTEx