SNP Report
Basic Info
| Name | rs142570922 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 8:142881701 - 142881701(+) | ||
| Variant Seq | C | ||
| Ref Seq | A | ||
| Annotation | upstream_gene_variant; intron_variant | ||
| Variant Effect | upstream_gene_variant(ENST00000377675, ENST00000292427, ENST00000314111, ENST00000517471); intron_variant(ENST00000522728) | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000292427, ENST00000377675, ENST00000517471) | ||
| PolyPhen Annotation | benign | ||
| PolyPhen Variant Effect | benign(ENST00000292427, ENST00000377675, ENST00000517471) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 0; Trend: 1) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | In meta-analysis: P-value=3.8E-06. In meta-analysis: P-value=3.8E-06. | It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More... | Trend |
G*E study related association result (count: 1)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | Childhood trauma | In subjects of Hispanic/Native American, gene and childhood ...... In subjects of Hispanic/Native American, gene and childhood trauma interaction: P-value=0.036. In other descents, gene and childhood trauma interaction: P-value=0.027. More... | It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More... | Significant |
SNP related genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CYP11B1 | cytochrome P450 family 11 subfamily B member 1 | 8q21-q22 | 1(0/0/1) |
| GML | glycosylphosphatidylinositol anchored molecule like | 8q24.3 | Mapped by Literature SNP |
SNPs in LD with rs142570922 (count: 0)
SNP related eQTL (count: 1)