Gene Report

Basic Info

Approved Symbol	CHRNA5
Approved Name	cholinergic receptor, nicotinic alpha 5
Previous Name	"cholinergic receptor, nicotinic, alpha polypeptide 5\|cholinergic receptor, nicotinic, alpha 5 (neuronal)"
Name Alias	acetylcholine receptor, nicotinic, alpha 5 (neuronal)
Location	15q24
Position	chr15:78565520-78595269, 1
External Links	HGNC: 1959 Entrez Gene: 1138 Ensembl: ENSG00000169684 UCSC: uc002bdy.3
No. of Association Results	2 (Positive: 1; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Marker	Gene's Category
Kimbrel, N. A.,2015	PTSD	rs12898919 ; rs16969968 ; rs588765 ; rs80087508	Significant
Nievergelt, C. M.,2015	PTSD	rs518425	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Kimbrel, N. A.,2015	PTSD	Smoking status	rs12898919 ; rs16969968 ; rs518425 ; rs588765 ; rs80087508	Significant

Gene functional annotation

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0007271	synaptic transmission, cholinergic	biological process	IBA	9
GO:0004889	acetylcholine-activated cation-selective channel activity	molecular function	NAS[1542648]; TAS[20438829]	8
GO:0042166	acetylcholine binding	molecular function	IBA	8
GO:0005892	acetylcholine-gated channel complex	cellular component	IBA; IC[1542648]	8
GO:0035095	behavioral response to nicotine	biological process	IMP[18227835]	4
GO:0015276	ligand-gated ion channel activity	molecular function	TAS[20438829]	4
GO:0007274	neuromuscular synaptic transmission	biological process	IBA	5
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0098655	cation transmembrane transport	biological process	IEA; NAS[1542648]; TAS[20438829]	8
GO:0007268	synaptic transmission	biological process	TAS[9009220]	32
GO:0015464	acetylcholine receptor activity	molecular function	IDA[1542648]	8
GO:0006810	transport	biological process	NAS[1542648]	8
GO:0046982	protein heterodimerization activity	molecular function	IEA	10
GO:0005515	protein binding	molecular function	IPI[8663494]	169
GO:0043025	neuronal cell body	cellular component	IEA	18
GO:0030425	dendrite	cellular component	IEA	19
GO:0030054	cell junction	cellular component	IEA	24
GO:0034220	ion transmembrane transport	biological process	TAS[20438829]	9
GO:0099565	chemical synaptic transmission, postsynaptic	biological process	IDA[1542648]	7
GO:0007165	signal transduction	biological process	NAS[9009220]	34

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 2)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CHRNA5	SRPK2	No	--	--	23602568
CHRNA5	CHRNB4	Yes	--	--	9655874