PTSDgene database

Variant Report

Basic Info
Name APOE_euro2/euro3/euro4
Type Point mutation
Related Gene APOE
No. of Association Result 1 (Positive: 1; Negative: 0; Trend: 0)

Variant related studies

Normal genetic study related association result (count: 1)

Reference Phenotype Statistical Values Author Comments Marker's Category
Kim, T. Y.,2013 PTSD In the main effect model, absence of euro2 allele: P-value=...... In the main effect model, absence of euro2 allele: P-value=0.007, adjusted OR=0.32, 95%CI=0.14-0.74. More... Allele frequencies differed significantly between the PTSD a...... Allele frequencies differed significantly between the PTSD and control groups. In addition, there were more euro2-allele carriers in the PTSD group than in the control group; however, no significant differences were observed between groups with respect to the numbers of euro3- and euro4-allele carriers. In the main effect model, the presence of PTSD increased with the intensity of combat trauma in a dose-dependent manner. In addition, both harmful drinking patterns and absence of the APOE euro2 allele were significantly associated with PTSD. More... Significant

Gene*Environment study related association results (count: 1)

Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Kim, T. Y.,2013 PTSD Harmful drinking In the interaction effect model, the harmful drinking x abse...... In the interaction effect model, the harmful drinking x absence of APOE euro2-allele interaction: P-value=0.005, adjusted OR=2.56, 95%CI=1.32-4.97. Post hoc stratified analysis in euro2-allele noncarriers: P-value= .001, OR=2.54, 95%CI=1.44-4.46, in euro2-allele carriers: P-value=.271, OR=1.18, 95%CI=.29-4.83. More... In the interaction effect model, only the harmful drinking x...... In the interaction effect model, only the harmful drinking x absence of APOE euro2-allele interaction was statistically significant. Post hoc stratified analysis also revealed that harmful drinking was associated with an increased risk of PTSD in euro2-allele noncarriers but not in euro2-allele carrier. More... Significant